scholarly journals miR-31-5p Regulates 14-3-3 ɛ to Inhibit Prostate Cancer 22RV1 Cell Survival and Proliferation via PI3K/AKT/Bcl-2 Signaling Pathway

2020 ◽  
Vol Volume 12 ◽  
pp. 6679-6694
Author(s):  
Jiafu Zhao ◽  
Houqiang Xu ◽  
Zhiqiang Duan ◽  
Xiang Chen ◽  
Zheng Ao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Survival ◽  
Signaling Pathway ◽  
22Rv1 Cell ◽  
Cell Survival And Proliferation

scholarly journals Inhibitor of differentiation 1 (Id1) promotes cell survival and proliferation of prostate epithelial cells

2010 ◽  
Vol 15 (2) ◽  
Author(s):  
Michelle Schmidt ◽  
Ananthi Asirvatham ◽  
Jaideep Chaudhary
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Epithelial Cells ◽  
Cell Survival ◽  
Ventral Prostate ◽  
Normal Prostate ◽  
Mesenchymal Transition ◽  
Prostate Epithelial Cells ◽  
Inhibitor Of Differentiation 1 ◽  
Cell Survival And Proliferation

AbstractId1 (inhibitor of differentiation 1) is a member of the bHLH protein family. Consistent with its role in promoting proliferation and inhibiting differentiation, Id1 expression is low or negligible in normal prostate epithelial cells but is high in prostate cancer. Ectopic expression of Id1 in normal prostate epithelial cells could therefore provide a model for understanding early events involved in initiation of prostate cancer. Over-expression of Id1 immortalized but did not transform ventral prostate epithelial cells (Id1-RPE). Immortalization was associated with decreased Cdkn2a, Cdkn1a, androgen receptor and increased Tert expression. Gene expression profiling over successive doublings was used to identify transcriptomic changes involved during immortalization (Tieg, Jun, alpha actin, Klf10, Id2) and in maintaining the immortalized phenotype (Igfbp3, Igfbp5, Mmp2, Tgfb3). Network analysis indicated that Id1 promotes cancer/tumor morphology, cell cycle and epithelial to mesenchymal transition by influencing AP1, tnf, tgfβ, PdgfBB and estradiol pathways. During immortalization, the expression of majority of differentially expressed genes reduced over progressive doublings suggesting a decline in transcriptional regulatory mechanisms. The associated molecular/gene expression profile of Id1-RPE cells provides an opportunity to understand the molecular pathways associated with prostate epithelial cell survival and proliferation.

Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3)

2011 ◽  
Vol 29 (2) ◽  
pp. 87-95 ◽  
Author(s):  
Kalimuthu Senthilkumar ◽  
Ramachandran Arunkumar ◽  
Perumal Elumalai ◽  
Govindaraj Sharmila ◽  
Dharmalingam Nandhagopal Gunadharini ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Survival ◽  
Cell Line ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Signalling Molecules ◽  
Cell Survival And Proliferation

Inhibition of cell survival and proliferation by nimbolide in human androgen-independent prostate cancer (PC-3) cells: involvement of the PI3K/Akt pathway

2016 ◽  
Vol 427 (1-2) ◽  
pp. 69-79 ◽  
Author(s):  
Paulraj Raja Singh ◽  
Elayapillai Sugantha Priya ◽  
Solaimuthu Balakrishnan ◽  
Ramachandran Arunkumar ◽  
Govindaraj Sharmila ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Survival ◽  
Akt Pathway ◽  
Androgen Independent ◽  
Cell Survival And Proliferation

The role of PI 3-kinase p110β in AKT signally, cell survival, and proliferation in human prostate cancer cells

The Prostate ◽  
2010 ◽  
Vol 70 (7) ◽  
pp. 755-764 ◽  
Author(s):  
Karen M. Hill ◽  
Sara Kalifa ◽  
Jharna R. Das ◽  
Tahira Bhatti ◽  
Martha Gay ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Cell Survival And Proliferation
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