scholarly journals Risk of Recurrence and Metastasis for Patients with T1N0M0 Esophageal Carcinoma Who Achieve Completed Resection via Endoscopic Submucosal Resection: Evidence for the Appropriateness of the Watch and Wait Follow-Up Strategy

2020 ◽  
Vol Volume 12 ◽  
pp. 2427-2435
Author(s):  
Li-hua Zhu ◽  
Jun Yao ◽  
Ting Wu ◽  
Yan Wang ◽  
Chen-Wei Wang ◽  
...  
Keyword(s):  
Esophageal Carcinoma ◽  
Watch And Wait ◽  
Risk Of Recurrence ◽  
Endoscopic Submucosal Resection ◽  
Submucosal Resection

Sa1659 Endoscopic Submucosal Resection for Remnant Early Gastric Cancer vs U Region Early Gastric Cancer

2014 ◽  
Vol 79 (5) ◽  
pp. AB291 ◽  
Author(s):  
Yasumasa Niwa ◽  
Makoto Ishihara ◽  
Masahiro Tajika ◽  
Tsutomu Tanaka ◽  
Toshihisa Fujiyoshi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Resection ◽  
Submucosal Resection

scholarly journals Targeted Plasma Metabolic Profiles and Risk of Recurrence in Stage II and III Colorectal Cancer Patients: Results from an International Cohort Consortium

Metabolites ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 129
Author(s):  
Jennifer Ose ◽  
Biljana Gigic ◽  
Stefanie Brezina ◽  
Tengda Lin ◽  
Andreas Baierl ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Multiple Testing ◽  
Tumor Stage ◽  
Stage Ii ◽  
Sphingolipid Metabolism ◽  
Risk Of Recurrence ◽  
Cox Proportional Hazard Models ◽  
Edta Plasma ◽  
Colorectal Cancer Patients

The identification of patients at high-risk for colorectal cancer (CRC) recurrence remains an unmet clinical need. The aim of this study was to investigate associations of metabolites with risk of recurrence in stage II/III CRC patients. A targeted metabolomics assay (128 metabolites measured) was performed on pre-surgery collected EDTA plasma samples from n = 440 newly diagnosed stage II/III CRC patients. Patients have been recruited from four prospective cohort studies as part of an international consortium: Metabolomic profiles throughout the continuum of CRC (MetaboCCC). Cox proportional hazard models were computed to investigate associations of metabolites with recurrence, adjusted for age, sex, tumor stage, tumor site, body mass index, and cohort; false discovery rate (FDR) was used to account for multiple testing. Sixty-nine patients (15%) had a recurrence after a median follow-up time of 20 months. We identified 13 metabolites that were nominally associated with a reduced risk of recurrence. None of the associations were statistically significant after controlling for multiple testing. Pathway topology analyses did not reveal statistically significant associations between recurrence and alterations in metabolic pathways (e.g., sphingolipid metabolism p = 0.04; pFDR = 1.00). To conclude, we did not observe statistically significant associations between metabolites and CRC recurrence using a well-established metabolomics assay. The observed results require follow-up in larger studies.

Recurrence and disease-specific survival after 10-year disease-free interval in patients with primary retroperitoneal liposarcoma: Implications for long-term surveillance.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 11546-11546
Author(s):  
Mark Archer Eckardt ◽  
Danielle S. Graham ◽  
Brian E. Kadera ◽  
Kyle D. Klingbeil ◽  
Scott D. Nelson ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Surgical Margin ◽  
Disease Specific Survival ◽  
Risk Of Recurrence ◽  
Retroperitoneal Liposarcoma ◽  
Initial Surgery ◽  
Surveillance Imaging ◽  
Disease Specific

11546 Background: Surveillance imaging of patients with retroperitoneal liposarcoma (RP-LPS) following surgical resection is based on a projected risk of locoregional and distant recurrence. The duration of surveillance is not well defined as the long-term natural history of RP-LPS after treatment is poorly understood. We evaluate a cohort of RP-LPS patients—without evidence of disease 10 years following initial resection—to assess the long-term risk of recurrence and disease-specific survival (DSS). Methods: The prospectively maintained UCLA Sarcoma Database was used to identify RP-LPS patients who demonstrated 10-year progression-free survival (10yr-PFS) after initial diagnosis and treatment. Patients in the 10yr-PFS cohort were subsequently evaluated for recurrence and DSS. Time intervals start at date of initial surgical resection. Cox proportional hazards models were used to determine factors associated with recurrence and DSS. Results: From 1972-2010, 76 patients with RP-LPS had at least 10 years of follow-up. Of these, 37 (49%) demonstrated 10yr-PFS. Median follow-up was 15 years (range 10-35 years). Among the 10yr-PFS patients, 43% (16/37) developed a recurrence >10 years after the initial surgery, and 19% (7/37) died of disease. Neither long-term recurrence nor DSS were significantly associated with age, sex, tumor size, LPS subtype, surgical margin, or peri-operative treatment with radiation or chemotherapy (Table). Conclusions: Patients with primary RP-LPS treated with surgical resection +/- multimodality therapy have a long-term risk of recurrence and disease-specific death that is unacknowledged by current surveillance imaging guidelines. Among the patients with a 10yr-PFS, 43% developed a recurrence and 19% died of disease. These findings suggest a need for lifelong surveillance imaging in patients with RP-LPS.[Table: see text]

Endoscopic submucosal resection of rectal carcinoid tumors with a ligation device

2003 ◽  
Vol 57 (4) ◽  
pp. 583-587 ◽  
Author(s):  
Akiko Ono ◽  
Takahiro Fujii ◽  
Yutaka Saito ◽  
Takahisa Matsuda ◽  
Daniel T.Y. Lee ◽  
...  
Keyword(s):  
Carcinoid Tumors ◽  
Rectal Carcinoid ◽  
Endoscopic Submucosal Resection ◽  
Submucosal Resection

Clinical Outcomes of Patients with Small Rectal Neuroendocrine Tumors Treated Using Endoscopic Submucosal Resection with a Ligation Device

Digestion ◽  
2018 ◽  
Vol 99 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Maiko Takita ◽  
Eiji Sakai ◽  
Tomomi Nakao ◽  
Yoshiaki Kimoto ◽  
Rindo Ishii ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Neuroendocrine Tumors ◽  
Endoscopic Submucosal Resection ◽  
Submucosal Resection

scholarly journals Prospective study on the value of endosonographic follow-up after surgery for esophageal carcinoma

1997 ◽  
Vol 46 (6) ◽  
pp. 487-491 ◽  
Author(s):  
Paul Fockens ◽  
Carin G. Manshanden ◽  
J.Jan B. van Lanschot ◽  
Hugo Obertop ◽  
Guido N.J. Tytgat
Keyword(s):  
Prospective Study ◽  
Esophageal Carcinoma

Republished: Delayed relapse in pseudotumor cerebri due to new stenosis after transverse sinus stenting

2015 ◽  
Vol 8 (10) ◽  
pp. e41-e41 ◽  
Author(s):  
Hugh Stephen Winters ◽  
Geoff Parker ◽  
Gabor Michael Halmagyi ◽  
Ankur Mehta ◽  
Thomas Atkins
Keyword(s):  
Intracranial Hypertension ◽  
Effective Treatment ◽  
Treatment Option ◽  
Small Proportion ◽  
Severe Disease ◽  
Pseudotumor Cerebri ◽  
Transverse Sinus ◽  
Effective Treatment Option ◽  
Risk Of Recurrence

A patient presented with recurrent severe pseudotumor cerebri (PTC). Transverse sinus stenting is a very effective treatment option, however stenosis and intracranial hypertension can recur. In our patient, stenting initially resulted in resolution of papilloedema. However, after 5 years, a new stenosis developed which required further stenting. This case highlights the fact that, in patients with PTC who undergo transverse sinus stenting, a small proportion require repeat treatment due to formation of a new stenosis, usually adjacent to the existing stent. Patients with severe disease, such as ours, may be at higher risk of recurrence. Regardless of the severity, all patients who undergo stenting should have regular ocular follow-up.

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