scholarly journals Paeonol Inhibits Pancreatic Cancer Cell Migration and Invasion Through the Inhibition of TGF-β1/Smad Signaling and Epithelial-Mesenchymal-Transition

2020 ◽  
Vol Volume 12 ◽  
pp. 641-651 ◽  
Author(s):  
Chien-Shan Cheng ◽  
Jing-Xian Chen ◽  
Jian Tang ◽  
Ya-Wen Geng ◽  
Lan Zheng ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Epithelial Mesenchymal Transition ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Mesenchymal Transition ◽  
Cell Migration And Invasion ◽  
Tgf Β1

scholarly journals Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial–Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1856 ◽  
Author(s):  
Wei ◽  
Penso ◽  
Hackman ◽  
Wang ◽  
Mackenzie
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Epithelial Mesenchymal Transition ◽  
Akt Pathway ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cancer Cell Growth ◽  
Mesenchymal Transition

Most pancreatic cancers are usually diagnosed at an advanced stage when they have already metastasized. Epigallocatechin-3-gallate (EGCG), a major polyphenolic constituent of green tea, has been shown to reduce pancreatic cancer growth, but its effect on metastasis remains elusive. This study evaluated the capacity of EGCG to inhibit pancreatic cancer cell migration and invasion and the underlying mechanisms. EGCG reduced pancreatic cancer cell growth, migration, and invasion in vitro and in vivo. EGCG prevented “Cadherin switch” and decreased the expression level of TCF8/ZEB1, β-Catenin, and Vimentin. Mechanistically, EGCG inhibited the Akt pathway in a time-dependent manner, by suppressing IGFR phosphorylation and inducing Akt degradation. Co-treatment with catalase or N-Acetyl-L-cysteine did not abrogate EGCG’s effect on the Akt pathway or cell growth. Moreover, EGCG synergized with gemcitabine to suppress pancreatic cancer cell growth, migration, and invasion, through modulating epithelial–mesenchymal transition markers and inhibiting Akt pathway. In summary, EGCG may prove beneficial to improve gemcitabine sensitivity in inhibiting pancreatic cancer cell migration and invasion, to some extent through the inhibition of Akt pathway and epithelial–mesenchymal transition.

scholarly journals Transient gene silencing of galectin-3 suppresses pancreatic cancer cell migration and invasion through degradation of β-catenin

2011 ◽  
Vol 129 (12) ◽  
pp. 2775-2786 ◽  
Author(s):  
Tsutomu Kobayashi ◽  
Tatsuo Shimura ◽  
Toshiki Yajima ◽  
Norio Kubo ◽  
Kenichiro Araki ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Migration ◽  
Gene Silencing ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion ◽  
Galectin 3

scholarly journals FHOD1, a Formin Upregulated in Epithelial-Mesenchymal Transition, Participates in Cancer Cell Migration and Invasion

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74923 ◽  
Author(s):  
Maria Gardberg ◽  
Katja Kaipio ◽  
Laura Lehtinen ◽  
Piia Mikkonen ◽  
Vanina D. Heuser ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cancer Cell ◽  
Epithelial Mesenchymal Transition ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Mesenchymal Transition ◽  
Cell Migration And Invasion

Tu1686 Attenuation of Pancreatic Cancer Cell Migration and Invasion Through a Targeted Inhibition of the Rac GEF Vav1

2014 ◽  
Vol 146 (5) ◽  
pp. S-818-S-819
Author(s):  
Gina L. Razidlo ◽  
Christopher Magnine ◽  
Arthur C. Sletten ◽  
Rachel M. Hurley ◽  
Mark A. McNiven
Keyword(s):  
Pancreatic Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion ◽  
Targeted Inhibition
Sign in / Sign up

Export Citation Format

Share Document