scholarly journals Conversion of immunohistochemical markers and breast density are associated with pathological response and prognosis in very young breast cancer patients who fail to achieve a pathological complete response after neoadjuvant chemotherapy

2019 ◽  
Vol Volume 11 ◽  
pp. 5677-5690
Author(s):  
Yue Zhao ◽  
Xiaolei Wang ◽  
Yuanxi Huang ◽  
Xianli Zhou ◽  
Dongwei Zhang
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Breast Density ◽  
Pathological Complete Response ◽  
Complete Response ◽  
Pathological Response ◽  
Breast Cancer Patients ◽  
Immunohistochemical Markers ◽  
Young Breast Cancer

scholarly journals Deep learning-based predictive biomarker of pathological complete response to neoadjuvant chemotherapy from histological images in breast cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Fengling Li ◽  
Yongquan Yang ◽  
Yani Wei ◽  
Ping He ◽  
Jie Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Deep Learning ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Pathological Complete Response ◽  
Predictive Biomarkers ◽  
Predictive Performance ◽  
Complete Response ◽  
Breast Cancer Patients ◽  
Histological Images

Abstract Background Pathological complete response (pCR) is considered a surrogate endpoint for favorable survival in breast cancer patients treated with neoadjuvant chemotherapy (NAC). Predictive biomarkers of treatment response are crucial for guiding treatment decisions. With the hypothesis that histological information on tumor biopsy images could predict NAC response in breast cancer, we proposed a novel deep learning (DL)-based biomarker that predicts pCR from images of hematoxylin and eosin (H&E)-stained tissue and evaluated its predictive performance. Methods In total, 540 breast cancer patients receiving standard NAC were enrolled. Based on H&E-stained images, DL methods were employed to automatically identify tumor epithelium and predict pCR by scoring the identified tumor epithelium to produce a histopathological biomarker, the pCR-score. The predictive performance of the pCR-score was assessed and compared with that of conventional biomarkers including stromal tumor-infiltrating lymphocytes (sTILs) and subtype. Results The pCR-score derived from H&E staining achieved an area under the curve (AUC) of 0.847 in predicting pCR directly, and achieved accuracy, F1 score, and AUC of 0.853, 0.503, and 0.822 processed by the logistic regression method, respectively, higher than either sTILs or subtype; a prediction model of pCR constructed by integrating sTILs, subtype and pCR-score yielded a mean AUC of 0.890, outperforming the baseline sTIL-subtype model by 0.051 (0.839, P  =  0.001). Conclusion The DL-based pCR-score from histological images is predictive of pCR better than sTILs and subtype, and holds the great potentials for a more accurate stratification of patients for NAC.

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