scholarly journals Prognostic role of a new inflammatory index with neutrophil-to-lymphocyte ratio and lactate dehydrogenase (CII: Colon Inflammatory Index) in patients with metastatic colorectal cancer: results from the randomized Italian Trial in Advanced Colorectal Cancer (ITACa) study

2019 ◽  
Vol Volume 11 ◽  
pp. 4357-4369 ◽  
Author(s):  
Andrea Casadei-Gardini ◽  
Emanuela Scarpi ◽  
Paola Ulivi ◽  
Maria Angela Palladino ◽  
Caterina Accettura ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lactate Dehydrogenase ◽  
Metastatic Colorectal Cancer ◽  
Advanced Colorectal Cancer ◽  
Neutrophil To Lymphocyte Ratio ◽  
Prognostic Role ◽  
Lymphocyte Ratio ◽  
Inflammatory Index

scholarly journals Prognostic role of aspartate aminotransferase-lymphocyte ratio index in patients with metastatic colorectal cancer: results from the randomized ITACa trial

2018 ◽  
Vol Volume 11 ◽  
pp. 5261-5268 ◽  
Author(s):  
Andrea Casadei Gardini ◽  
Emanuela Scarpi ◽  
Elena Orlandi ◽  
Davide Tassinari ◽  
Silvana Leo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Aspartate Aminotransferase ◽  
Prognostic Role ◽  
Lymphocyte Ratio

scholarly journals Prognostic role of a new index (multi inflammatory index) in patients with metastatic colorectal cancer: results from the randomized ITACa trial

2020 ◽  
Vol 12 ◽  
pp. 175883592095836
Author(s):  
Andrea Casadei Gardini ◽  
Emanuela Scarpi ◽  
Martina Valgiusti ◽  
Manlio Monti ◽  
Silvia Ruscelli ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Progression Free Survival ◽  
Predictive Capacity ◽  
Lymphocyte Ratio ◽  
Inflammatory Index ◽  
Reactive Protein ◽  
Clinical Covariates ◽  
Registration Date

Aims: We created a new index (Multi Inflammatory Index, MII) composed of an inflammatory index [neutrophil-to lymphocyte-ratio (NLR): MII-1; platelet-to-lymphocyte ratio (PLR): MII-2; or systemic immune-inflammation index (SII): MII-3] and C-reactive protein (CRP). Our aim was to evaluate the prognostic and/or predictive capacity of the MII in the randomized ITACa (Italian Trial in Advanced Colorectal Cancer) study on patients with metastatic colorectal cancer undergoing first-line chemotherapy. Methods: Between November 2007 and March 2012, baseline NLR, PLR; SII and CRP were available for 131 patients, 66 receiving chemotherapy plus bevacizumab and 65 receiving chemotherapy alone. Results: Patients with low (<25) MII-1 levels had a better outcome than those with high (⩾25) levels: median progression-free survival (PFS) was 12.4 versus 8.9 months [hazard ratio (HR) = 1.74, 95% confidence interval (CI) 1.21–2.51, p = 0.003] and median overall survival (OS) was 30.9 months versus 15.0 months (HR = 2.05, 95% CI 1.40–3.02, p = 0.0002), respectively. Similar results were obtained for patients with low (<1424) MII-2 levels compared with those with high (⩾1424) levels: median PFS was 12.6 versus 8.9 months (HR = 1.95, 95% CI 1.35–2.82, p = 0.0004) and median OS was 32.4 versus 14.6 months, respectively (HR = 2.42, 95% CI 1.64–3.57, p < 0.0001). Patients with low (<6068) MII-3 levels had a longer median PFS and OS than those with high (⩾6068) levels: 12.6 versus 8.9 months (HR = 1.91, 95% CI 1.33–2.76, p = 0.005) and 30.9 versus15.0 months (HR = 2.10, 95% CI 1.43–3.09, p = 0.0002), respectively. Following adjustment for clinical covariates, multivariate analysis confirmed all MII indexes as independent prognostic factors for predicting PFS and OS. Conclusion: All MII indexes appear to be useful as prognostic markers. Trial registration ClinicalTrials.gov identifier: NCT01878422 (registration date: 07/06/2013) https://clinicaltrials.gov/ct2/show/NCT01878422

Prognostic role of neutrophil-to-lymphocyte ratio in colorectal cancer: A systematic review and meta-analysis

2014 ◽  
Vol 134 (10) ◽  
pp. 2403-2413 ◽  
Author(s):  
Mu-Xing Li ◽  
Xue-Min Liu ◽  
Xu-Feng Zhang ◽  
Jian-Fei Zhang ◽  
Wan-Li Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Prognostic Role ◽  
Lymphocyte Ratio

scholarly journals Prognostic Role of the Platelet-to-Lymphocyte Ratio for Patients With Metastatic Colorectal Cancer Treated With Aflibercept

In Vivo ◽  
2020 ◽  
Vol 34 (5) ◽  
pp. 2667-2673
Author(s):  
AKIHISA MATSUDA ◽  
TAKESHI YAMADA ◽  
SATOSHI MATSUMOTO ◽  
SEIICHI SHINJI ◽  
RYO OHTA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Prognostic Role ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals The MIMIC Study: Prognostic Role and Cutoff Definition of Monocyte‐to‐Lymphocyte Ratio and Lactate Dehydrogenase Levels in Metastatic Colorectal Cancer

2020 ◽  
Vol 25 (8) ◽  
pp. 661-668
Author(s):  
Debora Basile ◽  
Silvio Ken Garattini ◽  
Carla Corvaja ◽  
Marcella Montico ◽  
Francesco Cortiula ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lactate Dehydrogenase ◽  
Metastatic Colorectal Cancer ◽  
Prognostic Role ◽  
Lymphocyte Ratio ◽  
Definition Of
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