scholarly journals The role and diagnostic potential of gastrokine 1 in gastric cancer

2019 ◽  
Vol Volume 11 ◽  
pp. 1921-1931 ◽  
Author(s):  
Olga M. Koper-Lenkiewicz ◽  
Joanna Kamińska ◽  
Beata Gawrońska ◽  
Joanna Matowicka-Karna
Keyword(s):  
Gastric Cancer ◽  
Diagnostic Potential ◽  
Gastrokine 1

Ectopic expression of gastrokine 1 in gastric cancer cells up-regulates tight and adherens junction proteins network

2015 ◽  
Vol 211 (8) ◽  
pp. 577-583 ◽  
Author(s):  
Emilia Rippa ◽  
Filomena Altieri ◽  
Chiara Stella Di Stadio ◽  
Giuseppina Miselli ◽  
Annalisa Lamberti ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Ectopic Expression ◽  
Adherens Junction ◽  
Gastric Cancer Cells ◽  
Gastrokine 1 ◽  
Adherens Junction Proteins ◽  
Junction Proteins

scholarly journals GLAD-PCR assay of R(5mC)GY sites in the regulatory region of tumor-suppressor genes associated with gastric cancer

Acta Naturae ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 124-133
Author(s):  
Boris S. Malyshev ◽  
Nina A. Netesova ◽  
Natalia A. Smetannikova ◽  
Murat A. Abdurashitov ◽  
Alexander G. Akishev ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Dna Methyltransferase ◽  
Regulatory Region ◽  
Pcr Assay ◽  
Suppressor Genes ◽  
Regulatory Regions ◽  
Tissue Samples ◽  
Diagnostic Potential

At early stages of carcinogenesis, the regulatory regions of some tumor suppressor genes become aberrantly methylated at RCGY sites, which are substrates of DNA methyltransferase Dnmt3. Identification of aberrantly methylated sites in tumor DNA is considered to be the first step in the development of epigenetic PCR test systems for early diagnosis of cancer. Recently, we have developed a GLAD-PCR assay, a method for detecting the R(5mC)GY site in the genome position of interest even at significant excess of DNA molecules with a non-methylated RCGY site in this location. The aim of the present work is to use the GLAD-PCR assay to detect the aberrantly methylated R(5mC)GY sites in the regulatory regions of tumor suppressor genes (brinp1, bves, cacna2d3, cdh11, cpeb1, epha7, fgf2, galr1, gata4, hopx, hs3st2, irx1, lrrc3b, pcdh10, rprm, runx3, sfrp2, sox17, tcf21, tfpi2, wnt5a, zfp82, and znf331) in DNA samples obtained from gastric cancer (GC) tissues. The study of the DNA samples derived from 29 tumor and 25 normal gastric tissue samples demonstrated a high diagnostic potential of the selected RCGY sites in the regulatory regions of the irx1, cacna2d3, and epha7 genes; the total indices of sensitivity and specificity for GC detection being 96.6% and 100%, respectively.

scholarly journals Gastrokine 1 inhibits gastric cancer cell migration and invasion by downregulating RhoA expression

2016 ◽  
Vol 20 (2) ◽  
pp. 274-285 ◽  
Author(s):  
Jung Hwan Yoon ◽  
Won Suk Choi ◽  
Olga Kim ◽  
Byung Joon Choi ◽  
Suk Woo Nam ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion ◽  
Gastrokine 1

scholarly journals Role of trefoil factor 1 in gastric cancer and relationship between trefoil factor 1 and gastrokine 1

2012 ◽  
Vol 28 (4) ◽  
pp. 1257-1262 ◽  
Author(s):  
WEI MAO ◽  
JIE CHEN ◽  
TIE-LI PENG ◽  
XIAO-FEI YIN ◽  
LIAN-ZHOU CHEN ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Trefoil Factor ◽  
Gastrokine 1 ◽  
Trefoil Factor 1

Preliminary Study of Diagnostic Potential of Raman Spectroscopy in Gastric Cancer

2007 ◽  
Vol 65 (5) ◽  
pp. AB328
Author(s):  
Kyoung Oh Kim ◽  
Jong-Jae Park ◽  
Jong Eun Yeon ◽  
Jae Seon Kim ◽  
Kwan Soo Byun ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Raman Spectroscopy ◽  
Diagnostic Potential ◽  
Preliminary Study

scholarly journals Gastrokine 1 induces senescence and apoptosis through regulating telomere length in gastric cancer

Oncotarget ◽  
2014 ◽  
Vol 5 (22) ◽  
pp. 11695-11708 ◽  
Author(s):  
Jung Hwan Yoon ◽  
Ho Seok Seo ◽  
Won Seok Choi ◽  
Olga Kim ◽  
Suk Woo Nam ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Telomere Length ◽  
Gastrokine 1

scholarly journals Evaluation of the Diagnostic Potential of a Plasma Exosomal miRNAs Panel for Gastric Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Jiajia Yang ◽  
Xuan Li ◽  
Shuchun Wei ◽  
Lei Peng ◽  
Huaiming Sang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Roc Curves ◽  
Diagnostic Efficiency ◽  
Roc Curve Analysis ◽  
Kaplan Meier ◽  
Diagnostic Potential ◽  
Training Stage ◽  
Exosomal Mirnas ◽  
Tumor Phenotype

PurposeGastric cancer (GC) is often difficult to diagnose early in the disease and remains one of the most frequently occurring malignancies. This investigation looks at the diagnostic potential of a specific plasma exosomal miRNAs panel for GC.MethodsThis study analyzed 216 individual peripheral blood samples. 2 GEO datasets were analyzed and two miRNAs were selected - plasma exosomal miR-195-5p and miR-211-5p. Quantitative reverse-transcriptase PCR (qRT–PCR) was used to assess relative expressions and receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic efficiency of miR-195-5p and miR-211-5p panel. The Kaplan-Meier method was used to assess the prognostic value of plasma exosomal miR-195-5p and miR-211-5p.ResultsGC patients possessed notably raised plasma levels of exosomal miR-195-5p and miR-211-5p. The area under ROC curves (AUCs) of miR-195-5p, miR-211-5p were 0.745, 0.798 in the screening phase and 0.762, 0.798 in the training stage respectively. GC was able to be diagnosed more accurately when both miRNAs were interpreted together (AUC=0.820 in the validation stage). Poorer prognosis was observed in GC patients who had plasma exosomal miR-195-5p and miR-211-5p of higher levels. In vitro experiments also confirmed that miR-195-5p and miR-211-5p is able to be transmitted between cells, and works to enhance tumor invasion, migration and proliferation while inhibiting cell apoptosis.ConclusionPlasma exosomal miR-195-5p and miR-211-5p may become potential biomarkers for GC diagnosis, and may be useful in predicting tumor phenotype.

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