scholarly journals FOXM1 promotes the growth and metastasis of colorectal cancer via activation of β-catenin signaling pathway

2019 ◽  
Vol Volume 11 ◽  
pp. 3779-3790 ◽  
Author(s):  
Kankan Yang ◽  
Bing Jiang ◽  
Yecai Lu ◽  
Qingbing Shu ◽  
Pan Zhai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Signaling Pathway ◽  
Beta Catenin

scholarly journals Radix Tetrastigma hemsleyani flavone exhibits antitumor activity in colorectal cancer via Wnt/β-catenin signaling pathway

2018 ◽  
Vol Volume 11 ◽  
pp. 6437-6446 ◽  
Author(s):  
Xiaowei Wu ◽  
Na Yu ◽  
Yuping Zhang ◽  
Yuanning Ye ◽  
Wenrong Sun ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Antitumor Activity ◽  
Signaling Pathway ◽  
Beta Catenin

scholarly journals ACBP suppresses the proliferation, migration, and invasion of colorectal cancer via targeting Wnt/beta-catenin signaling pathway

2021 ◽  
Vol 137 ◽  
pp. 111209
Author(s):  
Xin Tong ◽  
Zhuochen Zhuang ◽  
Xianjue Wang ◽  
Xiaoyu Yang ◽  
Liping Bai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Signaling Pathway ◽  
Migration And Invasion ◽  
Beta Catenin

scholarly journals CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Xiaofen Li ◽  
Wangxiong Hu ◽  
Jiaojiao Zhou ◽  
Yanqin Huang ◽  
Jiaping Peng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Signaling Pathway ◽  
Beta Catenin ◽  
Cancer Aggressiveness

scholarly journals Pyrvinium pamoate inhibits cell proliferation through ROS-mediated AKT-dependent signaling pathway in colorectal cancer

2021 ◽  
Vol 38 (2) ◽  
Author(s):  
Wenqian Zheng ◽  
Jinhui Hu ◽  
Yiming Lv ◽  
Bingjun Bai ◽  
Lina Shan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Signaling Pathway ◽  
Epithelial To Mesenchymal Transition ◽  
Flow Cytometric Analysis ◽  
Inhibitory Effect ◽  
Dependent Manner ◽  
Mesenchymal Transition ◽  
Dependent Signaling Pathway ◽  
Pyrvinium Pamoate

AbstractThe use of the anthelmintic drug pyrvinium pamoate (PP) in cancer therapy has been extensively investigated in the last decade. PP has been shown to have an inhibitory effect in colorectal cancer (CRC), but the underlying mechanism remains elusive. We aimed to investigate the antitumor activity and mechanisms of PP in CRC. In the present study, we used CCK-8 assays, colony formation assays, and western blotting to reveal that PP effectively suppressed CRC cell proliferation and the AKT-dependent signaling pathway in a concentration-dependent and time-dependent manner. Flow cytometric analysis and fluorescence microscopy demonstrated that PP increased intracellular reactive oxygen species (ROS) accumulation. We found that the inhibitory effect of PP on cell proliferation and AKT protein expression induced by PP could be partially reversed by N-acetyl-l-cysteine (NAC), an ROS scavenger. In addition, the results also demonstrated that PP inhibited cell migration by modulating epithelial-to-mesenchymal transition (EMT)-related proteins, including E-cadherin and vimentin. In conclusion, our data suggested that PP effectively inhibited cell proliferation through the ROS-mediated AKT-dependent signaling pathway in CRC, further providing evidence for the use of PP as an antitumor agent.

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