scholarly journals Notch signaling promotes serrated neoplasia pathway in colorectal cancer through epigenetic modification of EPHB2 and EPHB4

2018 ◽  
Vol Volume 10 ◽  
pp. 6129-6141 ◽  
Author(s):  
Haifeng Lian ◽  
Xingfang Jia ◽  
Ning Shi ◽  
Shuyang Xie ◽  
Jian Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Notch Signaling ◽  
Epigenetic Modification ◽  
Serrated Neoplasia Pathway

scholarly journals Amplified in breast cancer 1 promotes colorectal cancer progression through enhancing notch signaling

Oncogene ◽  
2014 ◽  
Vol 34 (30) ◽  
pp. 3935-3945 ◽  
Author(s):  
P Mo ◽  
Q Zhou ◽  
L Guan ◽  
Y Wang ◽  
W Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Notch Signaling ◽  
Cancer Progression ◽  
Colorectal Cancer Progression

scholarly journals SATB1 promotes epithelial-mesenchymal transition via Notch signaling pathway in colorectal cancer

2019 ◽  
Vol 17 ◽  
pp. 205873921985889
Author(s):  
Jun Tang ◽  
Jingfang Yang
Keyword(s):  
Colorectal Cancer ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Epithelial Mesenchymal Transition ◽  
Prognostic Biomarker ◽  
Notch Signaling Pathway ◽  
Vital Role ◽  
Cell Models ◽  
Mesenchymal Transition ◽  
Promising Therapeutic Target

Epithelial-mesenchymal transition (EMT) is essential for initiation of colorectal cancer (CRC) metastasis, but the diver proteins of EMT remain unclear. Special AT-rich sequence-binding protein 1 (SATB1) was found to be overexpressed in CRC cell lines, and its expression level was positively correlated with CRC progression. Strikingly, EMT process was regulated by SATB1, as SATB1 overexpression upregulated E-cadherin and SATB1 knockdown inhibited N-cadherin cell models. Mechanistically, SATB1 promoted EMT-mediated CRC metastasis via activation of Notch signaling pathway. Taken together, SATB1 plays a vital role in CRC metastasis and may act as a novel prognostic biomarker and a promising therapeutic target for CRC.

Silencing DVL3 defeats MTX resistance and attenuates stemness via Notch Signaling Pathway in colorectal cancer

2020 ◽  
Vol 216 (8) ◽  
pp. 152964
Author(s):  
Qian Zhao ◽  
Kun Zhuang ◽  
Kun Han ◽  
Hailing Tang ◽  
Yu Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Notch Signaling Pathway

Regulation of gene expression by DNA methylation with cytotoxic T lymphocytes evaluation in consensus molecular subtypes of colorectal cancer.

2020 ◽  
Vol 38 (5_suppl) ◽  
pp. 25-25
Author(s):  
Yuanyuan Shen ◽  
Justin Hummel ◽  
Isabel Cristina Trindade ◽  
Christos Papageorgiou ◽  
Chi-Ren Shyu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Dna Methylation ◽  
Molecular Subtypes ◽  
Epigenetic Modification ◽  
Pearson Correlation ◽  
Critical Role ◽  
Regulation Of Gene Expression ◽  
The Cancer Genome Atlas ◽  
Highly Correlated

25 Background: Low cytotoxic T lymphocyte (CTLs) infiltration in colorectal cancer (CRC) tumors is a challenge to treatment with immune checkpoint inhibitors. Consensus molecular subtypes (CMS) classify patients based on tumor attributes, and CMS1 patients include the majority of patients with high CTL infiltration and “inflamed” tumors. Epigenetic modification plays a critical role in gene expression and therapy resistance. Therefore, in this study we compared DNA methylation, gene expression, and CTL infiltration of CMS1 patients to other CMS groups to determine targets for improving immunotherapy in CRC. Methods: RNA-seq (n = 511) and DNA methylation (n = 316) from The Cancer Genome Atlas databases were used to determine gene expression and methylation profiles based on CMSs. CMS1 was used as a reference and compared to other subtypes (CMS2-4). Microenvironment Cell Populations- counter (MCPcounter) was used to determine tumor CTL infiltration. Genes with significantly different expression (p < 0.01, LogFC≥|1.5|) and difference of mean methylation β value ≥|0.25| were integrated for Pearson correlation coefficient analysis with MCPcounter score (r > |0.7|). Results: Comparing CMS1 and CMS2, ARHGAP9, TBX21, and LAG3 were differentially methylated and correlated with CTL scores. ARHGAP9 and TBX21 were decreased and hypomethylated in CMS2. Comparing CMS1 and CMS3, ARHGAP9, TBX21, FMNL1, HLA-DPB1, and STX11 were downregulated in CMS3 and highly correlated with CTL scores. ARHGAP9, FMNL1, HLA-DPB1, and STX11 were hypomethylated in CMS3 and TBX21 was methylated in both, but had a higher methylation ratio in CMS1. Comparing CMS1 and CMS4, TBX21 was the only gene downregulated, hypomethylated, and highly correlated with CTL scores in CMS4 patients. Conclusions: We found six genes differentially expressed, differentially methylated, and highly correlated with CTL infiltration when comparing CMS1 to other CMS groups. Specifically, TBX21 was the only gene highly correlated with CTL scores with differential gene expression and methylation in CMS2-4 when compared to CMS1. Thus, T-bet may be a critical regulator of T cell responses in CRC.

scholarly journals Role of Notch signaling in colorectal cancer

2009 ◽  
Vol 30 (12) ◽  
pp. 1979-1986 ◽  
Author(s):  
L. Qiao ◽  
B. C.Y. Wong
Keyword(s):  
Colorectal Cancer ◽  
Notch Signaling

scholarly journals Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

Cancer Cell ◽  
2019 ◽  
Vol 36 (3) ◽  
pp. 319-336.e7 ◽  
Author(s):  
Rene Jackstadt ◽  
Sander R. van Hooff ◽  
Joshua D. Leach ◽  
Xabier Cortes-Lavaud ◽  
Jeroen O. Lohuis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Microenvironment ◽  
Notch Signaling ◽  
Poor Prognosis

Abstract LB-285: Blocking Dll4/Notch signaling inhibits development of chronic colitis-associated colorectal cancer in mice

2011 ◽  
Author(s):  
Antonio Duarte ◽  
Marina Badenes ◽  
Alexandre Trindade ◽  
Ren Liu ◽  
Parkash S. Gill
Keyword(s):  
Colorectal Cancer ◽  
Notch Signaling ◽  
Chronic Colitis

scholarly journals Inhibition of cell proliferation and tumor growth of colorectal cancer by inhibitors of Wnt and Notch signaling pathways

2016 ◽  
Vol 12 (5) ◽  
pp. 3695-3700 ◽  
Author(s):  
Yuliang Xiao ◽  
Xiaojing Yang ◽  
Yinglei Miao ◽  
Xikun He ◽  
Ming Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Tumor Growth ◽  
Notch Signaling ◽  
Signaling Pathways

scholarly journals Evaluation and Clinical Significance of Jagged-1-activated Notch Signaling by APEX1 in Colorectal Cancer

2019 ◽  
Vol 39 (11) ◽  
pp. 6097-6105 ◽  
Author(s):  
HONG-BEUM KIM ◽  
HYUN-JONG LIM ◽  
HEE-JEONG LEE ◽  
JUN HEE PARK ◽  
SANG-GON PARK
Keyword(s):  
Colorectal Cancer ◽  
Notch Signaling ◽  
Clinical Significance
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