scholarly journals Trend in relative survival in squamous cervical cancer by decade from 1983 to 2012: a period analysis

2018 ◽  
Vol Volume 10 ◽  
pp. 3177-3191
Author(s):  
Jinna Wu ◽  
Huanhuan Sun ◽  
Shuncong Wang ◽  
Yan Yan ◽  
Fengze Sun ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Relative Survival ◽  
Period Analysis ◽  
Squamous Cervical Cancer

Survival of cervical cancer patients in Germany in the early 21st century: A period analysis by age, histology, and stage

2012 ◽  
Vol 51 (7) ◽  
pp. 915-921 ◽  
Author(s):  
Tianhui Chen ◽  
Lina Jansen ◽  
Adam Gondos ◽  
Katharina Emrich ◽  
Bernd Holleczek ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
21St Century ◽  
Period Analysis ◽  
Early 21St Century ◽  
The Early 21St Century

scholarly journals Morphological Characteristics and Clinical Significance of Different Types of Tumor Vessels in Patients with Stages I-IIA of Squamous Cervical Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-20 ◽  
Author(s):  
Marina A. Senchukova ◽  
Elena V. Makarova ◽  
Elena I. Shurygina ◽  
Nadezhda N. Volchenko
Keyword(s):  
Cervical Cancer ◽  
Clinical Significance ◽  
Lymphatic Vessels ◽  
Morphological Characteristics ◽  
Solid Component ◽  
Contact Type ◽  
Tumor Microvessels ◽  
Squamous Cervical Cancer ◽  
Different Types ◽  
Early Cervical Cancer

The determination of factors associated with progression of cervical cancer is important, both for a recurrence risk assessment and for determining optimal treatment tactics. Previously, we showed the prognostic value of different types of tumor microvessels (MVs) in gastric and breast cancer. The object of this research was to study the morphology and clinical significance of different tumor microvessels in early cervical cancer. A total of 65 archived paraffin blocks of patients with I-IIA stages of squamous cervical cancer were investigated. Samples were stained with Mayer hematoxylin and immunohistochemically using antibodies to CD34, podoplanin, HIF-1a, and Snail. The eight types of tumor MVs differed in morphology were identified. It was established that only the dilated capillaries (DСs) with weak expression of CD34, the contact type DCs, the capillaries in tumor solid component, and the lymphatic vessels in the lymphoid and polymorphic cell infiltrates of tumor stroma are associated with clinical and pathological characteristics of early cervical cancer. Preliminary results also suggest that a combination of fragmentation in tumor solid component and the contact type DCs may predict a recurrence of early cervical cancer. Given the small number of cervical cancer recurrences, the predictive significance of the described markers requires a more thorough examination.

scholarly journals Identification and Validation of Reference Genes for RT-qPCR Studies of Hypoxia in Squamous Cervical Cancer Patients

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0156259 ◽  
Author(s):  
Christina S. Fjeldbo ◽  
Eva-Katrine Aarnes ◽  
Eirik Malinen ◽  
Gunnar B. Kristensen ◽  
Heidi Lyng
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Reference Genes ◽  
Squamous Cervical Cancer

Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Concomitant Chemotherapy and Radiotherapy in Patients With Stage IB2, IIA, or IIB Squamous Cervical Cancer: A Randomized Controlled Trial

2018 ◽  
Vol 36 (16) ◽  
pp. 1548-1555 ◽  
Author(s):  
Sudeep Gupta ◽  
Amita Maheshwari ◽  
Pallavi Parab ◽  
Umesh Mahantshetty ◽  
Rohini Hawaldar ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Radical Surgery ◽  
Controlled Trial ◽  
Locally Advanced ◽  
Concomitant Chemotherapy ◽  
Randomized Controlled ◽  
Surgery Group ◽  
Squamous Cervical Cancer ◽  
Concomitant Chemoradiation

Purpose We compared the efficacy and toxicity of neoadjuvant chemotherapy followed by radical surgery versus standard cisplatin-based chemoradiation in patients with locally advanced squamous cervical cancer. Patients and Methods This was a single-center, phase III, randomized controlled trial ( ClinicalTrials.gov identifier: NCT00193739). Eligible patients were between 18 and 65 years old and had stage IB2, IIA, or IIB squamous cervical cancer. They were randomly assigned, after stratification by stage, to receive either three cycles of neoadjuvant chemotherapy using paclitaxel and carboplatin once every 3 weeks followed by radical hysterectomy or standard radiotherapy with concomitant cisplatin once every week for 5 weeks. Patients in the neoadjuvant group received postoperative adjuvant radiation or concomitant chemotherapy and radiotherapy, if indicated. The primary end point was disease-free survival (DFS), defined as survival without relapse or death related to cancer, and secondary end points included overall survival and toxicity. Results Between September 2003 and February 2015, 635 patients were randomly assigned, of whom 633 (316 patients in the neoadjuvant chemotherapy plus surgery group and 317 patients in the concomitant chemoradiation group) were included in the final analysis, with a median follow-up time of 58.5 months. The 5-year DFS in the neoadjuvant chemotherapy plus surgery group was 69.3% compared with 76.7% in the concomitant chemoradiation group (hazard ratio, 1.38; 95% CI, 1.02 to 1.87; P = .038), whereas the corresponding 5-year OS rates were 75.4% and 74.7%, respectively (hazard ratio, 1.025; 95% CI, 0.752 to 1.398; P = .87). The delayed toxicities at 24 months or later after treatment completion in the neoadjuvant chemotherapy plus surgery group versus the concomitant chemoradiation group were rectal (2.2% v 3.5%, respectively), bladder (1.6% v 3.5%, respectively), and vaginal (12.0% v 25.6%, respectively). Conclusion Cisplatin-based concomitant chemoradiation resulted in superior DFS compared with neoadjuvant chemotherapy followed by radical surgery in locally advanced cervical cancer.

scholarly journals Prospective Study of HPV16 Viral Load and Risk of In Situ and Invasive Squamous Cervical Cancer

2012 ◽  
Vol 22 (1) ◽  
pp. 150-158 ◽  
Author(s):  
Karin Sundström ◽  
Alexander Ploner ◽  
Lisen Arnheim Dahlström ◽  
Juni Palmgren ◽  
Joakim Dillner ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Viral Load ◽  
Prospective Study ◽  
Squamous Cervical Cancer

Improvement in survival in younger patients with acute lymphoblastic leukemia from the 1980s to the early 21st century

Blood ◽  
2009 ◽  
Vol 113 (7) ◽  
pp. 1408-1411 ◽  
Author(s):  
Dianne Pulte ◽  
Adam Gondos ◽  
Hermann Brenner
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Age Groups ◽  
Relative Survival ◽  
The United States ◽  
Period Analysis ◽  
Early 21St Century ◽  
Time Period ◽  
Improvement In Survival ◽  
Difficult Issue

Abstract Acute lymphoblastic leukemia (ALL) is an uncommon but highly fatal disease in adults. We used period analysis to data from the Surveillance, Epidemiology, and End Results (SEER) database to disclose changes in outcomes for patients diagnosed with ALL in the United States in the 2 decades between 1980–1984 and 2000–2004. Major improvement in survival was observed for patients less than 60 years of age. Improvement in survival was greater for women than for men, but was significant for both genders. The greatest improvement was seen in patients aged 15 to 19, in whom 5-year relative survival improved from 41.0% to 61.1%, and 10-year survival improved from 33.0% to 60.4%. Lesser but significant improvements were seen for age groups 20–29, 30–44, and 45–59. Survival for patients aged 60 and over remained essentially unchanged at levels around or below 10%, respectively. Survival has improved for patients with ALL over the time period studied, but treatment of older patients remains a difficult issue.

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