scholarly journals Genetic variants of ALDH2-rs671 and CYP2E1-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population

2018 ◽  
Vol Volume 10 ◽  
pp. 1037-1050 ◽  
Author(s):  
Xinping Ye ◽  
Xiangkun Wang ◽  
Liming Shang ◽  
Guangzhi Zhu ◽  
Hao Su ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Genetic Variants ◽  
Chinese Population

Genetic variants in IL-33/ST2 pathway with the susceptibility to hepatocellular carcinoma in a Chinese population

Cytokine ◽  
2019 ◽  
Vol 118 ◽  
pp. 124-129 ◽  
Author(s):  
Zhong-Heng Wei ◽  
Yue-Yong Li ◽  
Shi-Qing Huang ◽  
Zhong-Qiu Tan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Genetic Variants ◽  
Chinese Population

Identification of genetic variants in m6A modification genes associated with pancreatic cancer risk in the Chinese population

2021 ◽  
Vol 95 (3) ◽  
pp. 1117-1128
Author(s):  
Pingting Ying ◽  
Yao Li ◽  
Nan Yang ◽  
Xiaoyang Wang ◽  
Haoxue Wang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Chinese Population ◽  
Pancreatic Cancer Risk

scholarly journals Plasma interleukin-21 levels and genetic variants are associated with susceptibility to rheumatoid arthritis

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Youguo Hao ◽  
Lijun Xie ◽  
Jing Xia ◽  
Zhen Liu ◽  
Baoxiu Yang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Genetic Variants ◽  
Chinese Population ◽  
Healthy Controls ◽  
Nucleotide Polymorphisms ◽  
Das28 Score ◽  
Single Nucleotide ◽  
Chronic Inflammatory Condition ◽  
Chinese Subjects ◽  
Pro Inflammatory Cytokines

Abstract Background Rheumatoid Arthritis (RA) is a chronic inflammatory condition characterized by autoantibodies development and an elevated spectrum of pro-inflammatory cytokines. Previous reports highlighted a relationship between IL-21and the pathogenesis of RA. Although elevated IL-21 levels have been reported in RA patients, the association of common IL-21 genetic variants with a predisposition to RA development in the Chinese population lacks. Materials and methods Five hundred and fourteen Chinese subjects (healthy controls: 303 and rheumatoid arthritis patients: 211) were enrolled in the study. Clinical data of patients were collected from medical records, and patients were treated as per the guidelines. Common single nucleotide polymorphisms in the IL-21 gene (rs907715, rs2221903, rs2055979 and rs6822844) were genotyped by TaqMan SNPs genotyping method. IL-21 level in plasma of RA patients and healthy subjects was measured by ELISA. Results The plasma level of IL-21 was significantly higher in subjects with rheumatoid arthritis relative to healthy controls (p < 0.0001). A positive correlation was observed between IL-21 level and DAS28 score, indicating the association of the cytokine with the worsening of the disease (Spearman r = 0.61, p < 0.0001). The prevalence of AA genotype (rs2055979) was significantly higher in RA subjects than in the controls (p < 0.0001, χ2 = 34.73, OR = 4.34, 95% CI = 2.623 to 7.219). Furthermore, elevated plasma IL-21 was observed in the rs2055979-AA genotype compared to CC type (p < 0.0001). Conclusion IL-21 plays a crucial function in rheumatoid arthritis pathogenesis. IL-21 rs2055979 polymorphism is associated with IL-21 plasma levels and is predisposed to RA development in the Chinese population.

Genetic variants in GTF2H1 and risk of lung cancer: A case–control analysis in a Chinese population

Lung Cancer ◽  
2009 ◽  
Vol 63 (2) ◽  
pp. 180-186 ◽  
Author(s):  
Wenting Wu ◽  
Hongliang Liu ◽  
Rong Lei ◽  
Dan Chen ◽  
Shuyu Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Genetic Variants ◽  
Chinese Population ◽  
Case Control ◽  
Control Analysis ◽  
Case Control Analysis

scholarly journals Single nucleotide polymorphisms in MLH1 predict poor prognosis of hepatocellular carcinoma in a Chinese population

Oncotarget ◽  
2017 ◽  
Vol 8 (45) ◽  
pp. 80039-80049 ◽  
Author(s):  
Xiaonian Zhu ◽  
Wei Liu ◽  
Xiaoqiang Qiu ◽  
Zhigang Wang ◽  
Chao Tan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Single Nucleotide Polymorphisms ◽  
Chinese Population ◽  
Poor Prognosis ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Genetic Variants Associated with Myocardial Infarction and the Risk Factors in Chinese Population

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86332 ◽  
Author(s):  
Yongqin Wang ◽  
Lefeng Wang ◽  
Xin Liu ◽  
Yongzhi Zhang ◽  
Liping Yu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Genetic Variants ◽  
Chinese Population
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