scholarly journals Genetic variants in the exon region of versican predict survival of patients with resected early-stage hepatitis B virus-associated hepatocellular carcinoma

2018 ◽  
Vol Volume 10 ◽  
pp. 1027-1036 ◽  
Author(s):  
Xiaoguang Liu ◽  
Chuangye Han ◽  
Xiwen Liao ◽  
Long Yu ◽  
Guangzhi Zhu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Genetic Variants ◽  
Early Stage ◽  
B Virus ◽  
Exon Region

scholarly journals Whole-Exome Sequencing-Based Mutational Profiling of Hepatitis B Virus-Related Early-Stage Hepatocellular Carcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Hao Zhan ◽  
Jiahao Jiang ◽  
Qiman Sun ◽  
Aiwu Ke ◽  
Jinwu Hu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Axon Guidance ◽  
Exome Sequencing ◽  
Whole Exome Sequencing ◽  
Early Stage ◽  
Genetic Characteristics ◽  
Whole Exome ◽  
B Virus

Background. Hepatocellular carcinoma (HCC) ranks as the third leading cause of cancer-related mortality in China with increasing incidence. This study is designed to explore early genetic changes implicated in HCC tumorigenesis and progression by whole-exome sequencing. Methods. We firstly sequenced the whole exomes of 5 paired hepatitis B virus-related early-stage HCC and peripheral blood samples, followed by gene ontological analysis and pathway analysis of the single-nucleotide variants discovered. Then, the mutations of high frequency were further confirmed by Sanger sequencing. Results. We identified a mutational signature of dominant T:A>A:T transversion in early HCC and significantly enriched pathways including ECM-receptor interaction, axon guidance, and focal adhesion and enriched biological processes containing cell adhesion, axon guidance, and regulation of pH. Eight genes, including MUC16, UNC79, USH2A, DNAH17, PTPN13, TENM4, PCLO, and PDE1C, were frequently mutated. Conclusions. This study reveals a mutational profile and a distinct mutation signature of T:A>A:T transversion in early-stage HCC with HBV infection, which will enrich our understanding of genetic characteristics of the early-stage HCC.

scholarly journals Exome capture sequencing reveals new insights into hepatitis B virus-induced hepatocellular carcinoma at the early stage of tumorigenesis

2013 ◽  
Vol 30 (4) ◽  
pp. 1906-1912 ◽  
Author(s):  
YONG CHEN ◽  
LIJUAN WANG ◽  
HEXIANG XU ◽  
XINGXIANG LIU ◽  
YINGREN ZHAO
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Early Stage ◽  
Exome Capture ◽  
B Virus ◽  
Capture Sequencing

scholarly journals Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development

Hepatology ◽  
2012 ◽  
Vol 55 (5) ◽  
pp. 1426-1431 ◽  
Author(s):  
Lingmin Hu ◽  
Xiangjun Zhai ◽  
Jibin Liu ◽  
Minjie Chu ◽  
Shandong Pan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Leukocyte Antigen ◽  
Genetic Variants ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Virus Clearance ◽  
B Virus

scholarly journals Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma

2012 ◽  
Vol 45 (1) ◽  
pp. 72-75 ◽  
Author(s):  
De-Ke Jiang ◽  
Jielin Sun ◽  
Guangwen Cao ◽  
Yao Liu ◽  
Dongxin Lin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Genetic Variants ◽  
Hla Dq ◽  
B Virus
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