scholarly journals Effects of controlled ovarian stimulation on toxicity of TAC chemotherapy in early breast cancer patients

2018 ◽  
Vol Volume 10 ◽  
pp. 3931-3935 ◽  
Author(s):  
Stefanie de Groot ◽  
Leoni A Louwé ◽  
Ashna IE Ramautar ◽  
Johanneke EA Portielje ◽  
Aernout C Ogilvie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Ovarian Stimulation ◽  
Controlled Ovarian Stimulation ◽  
Breast Cancer Patients ◽  
Tac Chemotherapy

scholarly journals Specific protocols of controlled ovarian stimulation for oocyte cryopreservation in breast cancer patients

2018 ◽  
Vol 25 (6) ◽  
Author(s):  
F. Cavagna ◽  
A. Pontes ◽  
M. Cavagna ◽  
A. Dzik ◽  
N. F. Donadio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Total Dose ◽  
Cancer Patients ◽  
Ovarian Stimulation ◽  
Estradiol Level ◽  
Controlled Ovarian Stimulation ◽  
Oocyte Cryopreservation ◽  
Breast Cancer Patients ◽  
Specific Protocol ◽  
The Mean

Background Fertility preservation is an important concern in breast cancer patients. In the present investigation, we set out to create a specific protocol of controlled ovarian stimulation (cos) for oocyte cryopreservation in breast cancer patients.Methods From November 2014 to December 2016, 109 patients were studied. The patients were assigned to a specific random-start ovarian stimulation protocol for oocyte cryopreservation. The endpoints were the numbers of oocytes retrieved and of mature oocytes cryopreserved, the total number of days of ovarian stimulation, the total dose of gonadotropin administered, and the estradiol level on the day of the trigger.Results Mean age in this cohort was 31.27 ± 4.23 years. The average duration of cos was 10.0 ± 1.39 days. The mean number of oocytes collected was 11.62 ± 7.96 and the mean number of vitrified oocytes was 9.60 ± 6.87. The mean estradiol concentration on triggering day was 706.30 ± 450.48 pg/mL, and the mean dose of gonadotropins administered was 2610.00 ± 716.51 IU. When comparing outcomes by phase of the cycle in which cos was commenced, we observed no significant differences in the numbers of oocytes collected and vitrified, the length of ovarian stimulation, and the estradiol level on trigger day. The total dose of follicle-stimulating hormone and human menopausal gonadotropin administered was statistically greater in the group starting cos in the luteal phase than in the group starting in the late follicular phase.Conclusions Our results suggest that using a specific protocol with random-start ovarian stimulation for oocyte cryopreservation in breast cancer patients is effective and could be offered to young women undergoing oncologic treatment.

Methods of controlled ovarian stimulation for embryo/oocyte cryopreservation in breast cancer patients

2016 ◽  
Vol 2 (1) ◽  
pp. 47-59 ◽  
Author(s):  
Matteo Lambertini ◽  
Maria Carolina Pescio ◽  
Giulia Viglietti ◽  
Oranite Goldrat ◽  
Lucia Del Mastro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Ovarian Stimulation ◽  
Controlled Ovarian Stimulation ◽  
Oocyte Cryopreservation ◽  
Breast Cancer Patients
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