scholarly journals Sensitivity and positive predictive value of the registration of self-expanding metal stent treatment for obstructive colorectal cancer in two Danish nationwide registries

2018 ◽  
Vol Volume 10 ◽  
pp. 1411-1415 ◽  
Author(s):  
Tue Højslev Avlund ◽  
Rune Erichsen ◽  
Lene Hjerrild Iversen
Keyword(s):  
Colorectal Cancer ◽  
Positive Predictive Value ◽  
Predictive Value ◽  
Metal Stent ◽  
Obstructive Colorectal Cancer ◽  
Stent Treatment

scholarly journals Utility of the methylated SEPT9 test for the early detection of colorectal cancer: a systematic review and meta-analysis of diagnostic test accuracy

2020 ◽  
Vol 7 (1) ◽  
pp. e000355 ◽  
Author(s):  
Rohit Hariharan ◽  
Mark Jenkins
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Early Detection ◽  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Diagnostic Test ◽  
Predictive Value ◽  
Meta Analysis ◽  
Test Accuracy ◽  
Sensitivity Specificity

BackgroundCirculating tumour DNA from colorectal cancer (CRC) is a biomarker for early detection of the disease and therefore potentially useful for screening. One such biomarker is the methylated SEPT9 (mSEPT9) gene, which occurs during CRC tumourigenesis. This systematic review and meta-analysis aims to establish the sensitivity, specificity and accuracy of mSEPT9 tests for the early diagnosis of CRC.MethodsA systematic search of the relevant literature was conducted using Medline and Embase databases. Data were extracted from the eligible studies and analysed to estimate pooled sensitivity, specificity and diagnostic test accuracy.ResultsBased on 19 studies, the pooled estimates (and 95% CIs) for mSEPT9 to detect CRC were: sensitivity 69% (62–75); specificity 92% (89–95); positive likelihood ratio 9.1 (6.1–13.8); negative likelihood ratio 0.34 (0.27–0.42); diagnostic OR 27 (15–48) and area under the curve 0.89 (0.86–0.91). The test has a positive predictive value of 2.6% and negative predictive value of 99.9% in an average risk population (0.3% CRC prevalence), and 9.5% (positive predictive value) and 99.6% (negative predictive value) in a high-risk population (1.2% CRC prevalence).ConclusionThe mSEPT9 test has high specificity and moderate sensitivity for CRC and is therefore a potential alternative screening method for those declining faecal immunochemical test for occult blood (FIT) or other screening modalities. However, it is limited by its poor diagnostic performance for precancerous lesions (advanced adenomas and polyps) and its relatively high costs, and little is known about its acceptability to those declining to use the FIT.

298 Positive Predictive Value of Multitarget Stool DNA Testing for Colorectal Cancer Screening

2019 ◽  
Vol 114 (1) ◽  
pp. S174-S174
Author(s):  
Maryam Alimirah ◽  
Sandra Naffouj ◽  
Firas Askar ◽  
Omar Sadiq ◽  
Raxitkumar Jinjuvadia ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Positive Predictive Value ◽  
Colorectal Cancer Screening ◽  
Predictive Value ◽  
Dna Testing ◽  
Stool Dna ◽  
Stool Dna Testing

scholarly journals The two-week rule colorectal cancer pathway: an update on recent practice, the unsustainable burden on diagnostics and the role of faecal immunochemical testing

2020 ◽  
Vol 102 (4) ◽  
pp. 308-311 ◽  
Author(s):  
W Maclean ◽  
R Singh ◽  
P Mackenzie ◽  
D White ◽  
S Benton ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Positive Predictive Value ◽  
Cancer Detection ◽  
Predictive Value ◽  
Detection Rate ◽  
Rapid Assessment ◽  
Colorectal Disease ◽  
Significant Finding ◽  
Referral Criteria ◽  
Dramatic Rise

Introduction Survival for colorectal cancer is improved by earlier detection. Rapid assessment and diagnostic demand have created a surge in two-week rule referrals and have subsequently placed a greater burden on endoscopy services. Between 2009 and 2014, a mean of 709 patients annually were referred to Royal Surrey County Hospital with a detection rate of 53 cancers per year giving a positive predictive value for these patients of 7.5%. We aimed to assess what impact the 2015 changes in National Institute for Health and Care Excellence referral criteria had on local cancer detection rate and endoscopy services. Methods A prospectively maintained database of patients referred under the two-week rule pathway for April 2017–2018 was sub-analysed and the data cross-referenced with all diagnostic reports. Findings There were 1,414 referrals, which is double the number of previous years; 80.6% underwent endoscopy as primary investigation and 62 cancers were identified, 51 being of colorectal and anal origin (positive predictive value 3.6%). A total of 88 patients were diagnosed, with other significant colorectal disease defined as high-risk adenomas, colitis and benign ulcers. Overall, a total of 10.6% of our two-week rule patients had a significant finding. Since the 2015 referral criteria, despite a dramatic rise in two-week rule referrals, there has been no increase in cancer detection. It has placed significant pressure on diagnostic services. This highlights the need for a less invasive, cheaper yet sensitive test to rule out cancer such as faecal immunochemical testing that can enable clinicians to triage and reduce referral to endoscopy in symptomatic patients.

scholarly journals Alvarado score in acute appendicitis: revisited

2019 ◽  
Vol 6 (5) ◽  
pp. 1637
Author(s):  
Lakshmi Narayanan Seshadri ◽  
Preethi Baya reddy ◽  
L. N. Mohan
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Carcinoma ◽  
Acute Appendicitis ◽  
Positive Predictive Value ◽  
Surgical Procedures ◽  
Predictive Value ◽  
Clinical Presentation ◽  
Histopathological Diagnosis ◽  
Alvarado Score ◽  
Suspected Acute Appendicitis

Background: Colorectal cancer (CRC) is a disease with a major worldwide burden. It is the fourth most frequently diagnosed malignancy in both sexes with almost 1 million people developing CRC annually. The present study of colorectal carcinoma helps us to determine the disease on clinical presentation, histopathological typing and grading; to know surgical procedures and other therapeutic options as well as the outcome of the disease.Methods: We retrospectively analyzed two hundred and four adult patients who were operated for suspected acute appendicitis between September 2003 and August 2008.Results: Patients with Alvarado scores more than 6 were most likely to have acute appendicitis. Patients with biopsy confirmed acute appendicitis had a mean score 6.16±1.84 (p=0.0001). Patients with histopathology showing no acute appendicitis had a mean score of 4.15±1.86 (p=0.0001). The overall positive predictive value of the Alvarado scoring is 95 and.Conclusions: The Alvarado score is useful in diagnosing acute appendicitis and a high score strongly correlates with a definitive operative and histopathological diagnosis of acute appendicitis. We propose that a diagnosis of acute appendicitis can be made with a score of >6 as compared to a score of >8 as described in literature.

Sign in / Sign up

Export Citation Format

Share Document