scholarly journals Density abnormalities in normal-appearing gray matter in the middle-aged brain with white matter hyperintense lesions: a DARTEL-enhanced voxel-based morphometry study

2016 ◽  
pp. 615 ◽  
Author(s):  
Fu-Qing Zhou ◽  
Yan Peng ◽  
Sheng-Hong Li ◽  
Xiaojia Liu ◽  
Ying Zhuang ◽  
...  
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
Voxel Based Morphometry ◽  
Middle Aged ◽  
Aged Brain

Association of regional gray matter volume loss and progression of white matter lesions in multiple sclerosis — A longitudinal voxel-based morphometry study

NeuroImage ◽  
2009 ◽  
Vol 45 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Kerstin Bendfeldt ◽  
Pascal Kuster ◽  
Stefan Traud ◽  
Hanspeter Egger ◽  
Sebastian Winklhofer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
White Matter Lesions ◽  
Volume Loss ◽  
Voxel Based Morphometry ◽  
Matter Volume

scholarly journals Regional gray matter correlates of memory for emotion-laden words in middle-aged and older adults: A voxel-based morphometry study

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0182541 ◽  
Author(s):  
Carina Saarela ◽  
Juho Joutsa ◽  
Matti Laine ◽  
Riitta Parkkola ◽  
Juha O. Rinne ◽  
...  
Keyword(s):  
Older Adults ◽  
Gray Matter ◽  
Voxel Based Morphometry ◽  
Middle Aged

scholarly journals Association between Toxoplasma gondii seropositivity and serointensity and brain volume in adults: A cross-sectional study

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0245994
Author(s):  
Lance D. Erickson ◽  
Bruce L. Brown ◽  
Shawn D. Gale ◽  
Dawson W. Hedges
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Toxoplasma Gondii ◽  
Confidence Interval ◽  
Gray Matter ◽  
Percent Confidence Interval ◽  
Middle Aged ◽  
Community Based ◽  
Matter Volume ◽  
Gray Matter Volumes

The intracellular protozoal parasite Toxoplasma gondii has been associated with worsened cognitive function in animal models and in humans. Despite these associations, the mechanisms by which Toxoplasma gondii might affect cognitive function remain unknown, although Toxoplasma gondii does produce physiologically active intraneuronal cysts and appears to affect dopamine synthesis. Using data from the UK Biobank, we sought to determine whether Toxoplasma gondii is associated with decreased prefrontal, hippocampal, and thalamic gray-matter volumes and with decreased total gray-matter and total white-matter volumes in an adult community-based sample. The results from adjusted multivariable regression modelling showed no associations between Toxoplasma gondii and prefrontal, hippocampal, and thalamic brain gray-matter volumes. In contrast, natural-log transformed antibody levels against the Toxoplasma gondii p22 (b = -3960, 95-percent confidence interval, -6536 to -1383, p < .01) and sag1 (b = -4863, 95-percent confidence interval, –8301 to -1425, p < .01) antigens were associated with smaller total gray-matter volume, as was the mean of natural-log transformed p22 and sag1 titers (b = -6141, 95-percent confidence interval, -9886 to -2397, p < .01). There were no associations between any of the measures of Toxoplasma gondii and total white-matter volume. These findings suggest that Toxoplasma gondii might be associated with decreased total gray-matter in middle-aged and older middle-aged adults in a community-based sample from the United Kingdom.

Reduced gray matter volume in patients with retinal detachment: evidence from a voxel-based morphometry study

2019 ◽  
Vol 61 (3) ◽  
pp. 395-403
Author(s):  
Biao Li ◽  
Yu-Xin Liu ◽  
Hai-Jun Li ◽  
Qing Yuan ◽  
Pei-Wen Zhu ◽  
...  
Keyword(s):  
White Matter ◽  
Retinal Detachment ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Cingulate Gyrus ◽  
Voxel Based Morphometry ◽  
White Matter Volume ◽  
Whole Brain ◽  
Matter Volume ◽  
Brain White Matter

Background We know little about the pathogenesis and diagnosis of retinal detachment. Purpose To assess spontaneous changes in the cerebral cortex of patients with retinal detachment using voxel-based morphometry and to explore the relationship between retinal detachment and clinical behavioral performance. Material and Methods Patients (14 men, 6 women; average age = 49.15 ± 10.32 years) with rhegmatogenous retinal detachment (duration of 24.05 ± 19.61 days) and 20 matched healthy controls were recruited. All participants underwent repeated functional magnetic resonance imaging scans. The original three-dimensional T1 brain images were analyzed using voxel-based morphometry and whole brain white matter volume and whole brain gray matter volume were compared with those of the control group. A receiver operating characteristic (ROC) curve was used to classify the mean gray matter volume values of the patients with retinal detachment compared with the controls. Results Compared with the controls, whole brain gray matter volume was significantly reduced in patients with retinal detachment, as evidenced by changes in the right inferior frontal gyrus, right superior temporal gyrus, right anterior cingulate gyrus, and right cuneus. In addition, the posterior lobe of the cerebellum, left hippocampus, left cingulate gyrus, and left middle temporal gyrus were also obviously atrophied. Furthermore, whole brain white matter volume of the patients with retinal detachment showed a slight reduction. The ROC curve analysis of each brain region showed that the accuracy of the area under the curve was high. Conclusion We proved that patients with retinal detachment had unusual changes in the gray matter volume and white matter volume in vision-related brain regions, which could reveal potential pathological mechanisms of retinal detachment.

scholarly journals Circulating cortisol and cognitive and structural brain measures

Neurology ◽  
2018 ◽  
Vol 91 (21) ◽  
pp. e1961-e1970 ◽  
Author(s):  
Justin B. Echouffo-Tcheugui ◽  
Sarah C. Conner ◽  
Jayandra J. Himali ◽  
Pauline Maillard ◽  
Charles S. DeCarli ◽  
...  
Keyword(s):  
White Matter ◽  
Visual Perception ◽  
Gray Matter ◽  
Brain Volume ◽  
Brain Mri ◽  
Serum Cortisol ◽  
Community Dwelling ◽  
White Matter Hyperintensity ◽  
Middle Aged ◽  
Middle Aged Adults

ObjectiveTo assess the association of early morning serum cortisol with cognitive performance and brain structural integrity in community-dwelling young and middle-aged adults without dementia.MethodsWe evaluated dementia-free Framingham Heart Study (generation 3) participants (mean age 48.5 years, 46.8% men) who underwent cognitive testing for memory, abstract reasoning, visual perception, attention, and executive function (n = 2,231) and brain MRI (n = 2018) to assess total white matter, lobar gray matter, and white matter hyperintensity volumes and fractional anisotropy (FA) measures. We used linear and logistic regression to assess the relations of cortisol (categorized in tertiles, with the middle tertile as referent) to measures of cognition, MRI volumes, presence of covert brain infarcts and cerebral microbleeds, and voxel-based microstructural white matter integrity and gray matter density, adjusting for age, sex, APOE, and vascular risk factors.ResultsHigher cortisol (highest tertile vs middle tertile) was associated with worse memory and visual perception, as well as lower total cerebral brain and occipital and frontal lobar gray matter volumes. Higher cortisol was associated with multiple areas of microstructural changes (decreased regional FA), especially in the splenium of corpus callosum and the posterior corona radiata. The association of cortisol with total cerebral brain volume varied by sex (p for interaction = 0.048); higher cortisol was inversely associated with cerebral brain volume in women (p = 0.001) but not in men (p = 0.717). There was no effect modification by the APOE4 genotype of the relations of cortisol and cognition or imaging traits.ConclusionHigher serum cortisol was associated with lower brain volumes and impaired memory in asymptomatic younger to middle-aged adults, with the association being evident particularly in women.

scholarly journals P3-323: WHITE MATTER HYPERINTENSITIES MEDIATE THE RELATIONSHIP BETWEEN GRAY MATTER VOLUME AND EXECUTIVE FUNCTION IN COGNITIVELY UNIMPAIRED MIDDLE-AGED INDIVIDUALS

2019 ◽  
Vol 15 ◽  
pp. P1061-P1062
Author(s):  
Anna Brugulat-Serrat ◽  
Gemma Salvadó ◽  
Grégory Operto ◽  
Raffaele Cacciaglia ◽  
Carole H. Sudre ◽  
...  
Keyword(s):  
Executive Function ◽  
White Matter ◽  
Gray Matter ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Middle Aged ◽  
Matter Volume ◽  
The Relationship
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