scholarly journals Severe aortic valve stenosis in the elderly: high prevalence of sleep-related breathing disorders

2015 ◽  
pp. 1451
Author(s):  
Stephan Steiner ◽  
Stefanie Keymel ◽  
Katharina Hellhammer ◽  
Tobias Zeus ◽  
Marc Merx ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
The Elderly ◽  
Sleep Related Breathing Disorders ◽  
Breathing Disorders ◽  
High Prevalence

scholarly journals 0804 Sleep Bruxism, Awake Bruxism and Sleep Related Breathing Disorders in Adults With Down Syndrome

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A306-A306
Author(s):  
L Giannasi ◽  
M Meira e Cruz ◽  
T Rezende ◽  
M Dutra ◽  
S Nacif ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Sleep Stage ◽  
Video Recording ◽  
Sleep Bruxism ◽  
Assessment Tools ◽  
Sleep Related Breathing Disorders ◽  
Sleep Study ◽  
Breathing Disorders ◽  
High Prevalence ◽  
Awake Bruxism

Abstract Introduction To our knowledge, no studies have accessed theawake bruxism (AB) and stage by stage sleep bruxism (SB) in adults with Down syndrome. Recent works have shown that portable PSG systems are accurate for SB assessment even in the absence of audio-video recording. We aimed to evaluate the prevalence of awake bruxism, stage-by-stage sleep bruxism and Sleep Related Breathing Disorders (SRBD) in adults with Down syndrome. Methods Twenty-three adults with Down Syndrome (DS) were enrolled in this study. General health, dental status, parafunctional habits and temporomandibular symptoms were assessed. The history of SB/AB was taken from a questionnaire to the caregivers. A portable PSG type II system (Embla Embletta MPR+PG ST+Proxy, Natus, California-USA) was used to perform a full-sleep study at patients’ home. RMMA activity was defined as low (>1 and <2 episodes/h of sleep), moderate (>2 and <4 episodes/h of sleep), or high (>4 episodes/h of sleep). PSG diagnose of SB was assumed if RMMA index was >2 episodes/h of sleep. Results According to caregiver’s report, AB was present in all patients whereas only 13.1% had SB. PSG records showed a SB prevalence of 91.3%, with a mean RMMA index 40.0±30.0/h. Only 2 (8,7%) showed RMMA index of 0.0/h. SB episodes were predominant in N3 and REM sleep stage in 14 and 9 patients, respectively. All but one (95,7%) patient (isolated snoring) presented with OSA (AHI=32.8±28.6). A unique TMD symptom (pain on palpation) was present in 8,7% of the global sample. Conclusion The high prevalence of “definitive SB” together with the high prevalence of OSA and snoring point in favor to the recommendation of routine PSG in adults with DS. Furthermore, the low sensitivity of parent-oriented questionnaires reinforces the need of more accurate assessment tools in order to get a better standard of care in this particular group of patients. Support State of Sao Paulo Research Support Foundation - FAPESP grant number: 2017/06835-8

scholarly journals Current State of Symptomatic Aortic Valve Stenosis in the Elderly Patient

2011 ◽  
Vol 75 (10) ◽  
pp. 2324-2325 ◽  
Author(s):  
Anna Sonia Petronio ◽  
Cristina Giannini ◽  
Leonardo Misuraca
Keyword(s):  
Elderly Patient ◽  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
The Elderly ◽  
Current State

Treatment with HMG-CoA reductase inhibitors (statins) attenuates the progression of aortic valve stenosis in the elderly

2006 ◽  
Vol 6 (2) ◽  
pp. 124-128 ◽  
Author(s):  
Masanori Kuwabara ◽  
Hiroaki Kitaoka ◽  
Makoto Okawa ◽  
Takashi Furuno ◽  
Masanori Nishinaga ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
The Elderly ◽  
Hmg Coa Reductase ◽  
Reductase Inhibitors ◽  
Hmg Coa Reductase Inhibitors ◽  
Coa Reductase

scholarly journals Plasma and urine metabolomic analyses in aortic valve stenosis reveal shared and biofluid-specific changes in metabolite levels

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242019
Author(s):  
Cynthia Al Hageh ◽  
Ryan Rahy ◽  
Georges Khazen ◽  
Francois Brial ◽  
Rony S. Khnayzer ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Elderly Population ◽  
The Elderly ◽  
Gas Chromatography Mass Spectrometry ◽  
Urine Metabolites ◽  
Aconitic Acid ◽  
Surgery In The Elderly ◽  
Diagnostic Applications ◽  
And Control

Aortic valve stenosis (AVS) is a prevalent condition among the elderly population that eventually requires aortic valve replacement. The lack of reliable biomarkers for AVS poses a challenge for its early diagnosis and the application of preventive measures. Untargeted gas chromatography mass spectrometry (GC-MS) metabolomics was applied in 46 AVS cases and 46 controls to identify plasma and urine metabolites underlying AVS risk. Multivariate data analyses were performed on pre-processed data (e.g. spectral peak alignment), in order to detect changes in metabolite levels in AVS patients and to evaluate their performance in group separation and sensitivity of AVS prediction, followed by regression analyses to test for their association with AVS. Through untargeted analysis of 190 urine and 130 plasma features that could be detected and quantified in the GC-MS spectra, we identified contrasting levels of 22 urine and 21 plasma features between AVS patients and control subjects. Following metabolite assignment, we observed significant changes in the concentration of known metabolites in urine (n = 14) and plasma (n = 15) that distinguish the metabolomic profiles of AVS patients from healthy controls. Associations with AVS were replicated in both plasma and urine for about half of these metabolites. Among these, 2-Oxovaleric acid, elaidic acid, myristic acid, palmitic acid, estrone, myo-inositol showed contrasting trends of regulation in the two biofluids. Only trans-Aconitic acid and 2,4-Di-tert-butylphenol showed consistent patterns of regulation in both plasma and urine. These results illustrate the power of metabolomics in identifying potential disease-associated biomarkers and provide a foundation for further studies towards early diagnostic applications in severe heart conditions that may prevent surgery in the elderly.

scholarly journals Sleep-related breathing disorders in patients with heart failure: classification, epidemiology and pathophysiology. Part I

2021 ◽  
Vol 26 (2S) ◽  
pp. 4386
Author(s):  
K. S. Krupichka ◽  
M. V. Agaltsov ◽  
R. P. Myasnikov ◽  
O. M. Drapkina
Keyword(s):  
Heart Failure ◽  
Sleep Apnea ◽  
Central Sleep Apnea ◽  
Periodic Breathing ◽  
Healthy Person ◽  
Underlying Disease ◽  
Sleep Related Breathing Disorders ◽  
Breathing Disorders ◽  
Obstructive Sleep ◽  
High Prevalence

The problem of heart failure (HF) is one of the central problems in modern cardiology due to its high prevalence among the population and high mortality. In turn, sleep-related breathing disorders (SRBD) are widespread in patients with HF and are associated with both the progression of the underlying disease and a decrease in the quality of life. For the first time, periodic breathing, as one of the types of sleep breathing disorders, was described in patients with HF.Further study of the issue showed a high prevalence of other types of SRBD among patients with HF The article discusses the physiology of sleep breathing monitoring in a healthy person and the pathophysiology of SRBD. The pathogenesis of central sleep apnea and its relationship with HF are discussed in detail. In addition, the mechanisms of the adverse effect of obstructive sleep apnea and HF are highlighted.

The Congenital Bicuspid Aortic Valve Can Experience Fluid Shear Stresses Associated With Sclerosis

2011 ◽  
Author(s):  
Choon Hwai Yap ◽  
Neelakantan Saikrishnan ◽  
Swetha Rathan ◽  
Gowthami Tamilselvan ◽  
Nikolay V. Vasilyev ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Ex Vivo ◽  
The Elderly ◽  
Shear Stresses ◽  
Dependent Manner ◽  
Aortic Valve Calcification ◽  
Fluid Shear ◽  
Valve Calcification ◽  
Mechanical Environment ◽  
High Prevalence

Aortic valve calcification is a degenerative disease with high prevalence, especially amongst the elderly, and is a major cause of morbidity and mortality. Ex vivo experiments has shown that aortic valve leaflets are sensitive to their mechanical environment in a magnitude dependent manner. Fluid shear stresses, specifically, has been shown to affect inflammatory and remodeling responses relevant to aortic valve calcification [1,2].

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