scholarly journals The Electronic Frailty Index is Associated with Increased Infection and All-Cause Mortality Among Older Patients with Primary Lung Cancer: A Cohort Study

2021 ◽  
Vol Volume 16 ◽  
pp. 1825-1833
Author(s):  
Yanjiao Shen ◽  
Yuting Wang ◽  
Qingyang Shi ◽  
Lisha Hou ◽  
Xiaoyan Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Older Patients ◽  
Frailty Index ◽  
Primary Lung Cancer ◽  
All Cause Mortality

scholarly journals Increased risk of secondary lung cancer in patients with tuberculosis: A nationwide, population-based cohort study

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0250531
Author(s):  
Li-Ju Ho ◽  
Hung-Yi Yang ◽  
Chi-Hsiang Chung ◽  
Wei-Chin Chang ◽  
Sung-Sen Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Large Scale ◽  
Primary Lung Cancer ◽  
Significant Risk ◽  
Population Based ◽  
Chronic Obstructive ◽  
Primary Cancer ◽  
Increased Risk ◽  
Subsequent Risk

Background Tuberculosis (TB) presents a global threat in the world and the lung is the frequent site of metastatic focus. A previous study demonstrated that TB might increase primary lung cancer risk by two-fold for more than 20 years after the TB diagnosis. However, no large-scale study has evaluated the risk of TB and secondary lung cancer. Thus, we evaluated the risk of secondary lung cancer in patients with or without tuberculosis (TB) using a nationwide population-based dataset. Methods In a cohort study of 1,936,512 individuals, we selected 6934 patients among patients with primary cancer and TB infection, based on the International Classification of Disease (ICD-p-CM) codes 010–011 from 2000 to 2015. The control cohort comprised 13,868 randomly selected, propensity-matched patients (by age, gender, and index date) without TB exposure. Using this adjusted date, a possible association between TB and the risk of developing secondary lung cancer was estimated using a Cox proportional hazards regression model. Results During the follow-up period, secondary lung cancer was diagnosed in 761 (10.97%) patients with TB and 1263 (9.11%) patients without TB. After adjusting for covariates, the risk of secondary lung cancer was 1.67 times greater among primary cancer in the cohort with TB than in the cohort without TB. Stratification revealed that every comorbidity (including diabetes, hypertension, cirrhosis, congestive heart failure, cardiovascular accident, chronic kidney disease, chronic obstructive pulmonary disease) significantly increased the risk of secondary lung cancer when comparing the TB cohort with the non-TB cohort. Moreover, the primary cancer types (including head and neck, colorectal cancer, soft tissue sarcoma, breast, kidney, and thyroid cancer) had a more significant risk of becoming secondary lung cancer. Conclusion A significant association exists between TB and the subsequent risk for metastasis among primary cancers and comorbidities. Therefore, TB patients should be evaluated for the subsequent risk of secondary lung cancer.

Clinical Characteristics and Surgery of Primary Lung Cancer in Younger Patients

2008 ◽  
Vol 16 (5) ◽  
pp. 387-391 ◽  
Author(s):  
Yasunobu Funakoshi ◽  
Shin-Ichi Takeda ◽  
Yoshihisa Kadota ◽  
Takashi Kusu ◽  
Hajime Maeda
Keyword(s):  
Lung Cancer ◽  
Cell Carcinoma ◽  
Older Patients ◽  
Clinical Characteristics ◽  
Early Stage ◽  
Survival Rates ◽  
Primary Lung Cancer ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Younger Patients

Controversy exists regarding the clinical characteristics, pathological findings, and prognosis of patients < 50 years of age with primary lung cancer. The medical records of 4,556 patients diagnosed with primary lung cancer between 1980 and 2004 were reviewed; of these, 305 were < 50 years old. Of 1,335 patients who were surgically treated, 122 were < 50 years old. Females were over-represented in the younger group. Younger patients had a significantly higher incidence of adenocarcinoma and large cell carcinoma, and a lower incidence of squamous cell carcinoma. The resectable rate in younger patients was significantly higher. Overall and among surgically treated patients, the survival rates of younger patients with stage 0-I disease were significantly better than those of older patients. Younger patients with early-stage primary lung cancer had a significantly better prognosis than older patients, although survival in the advanced stages was not significantly different.

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