scholarly journals Effects of Donor-Recipient Age Difference in Renal Transplantation, an Investigation on Renal Function and Fluid Proteome

2021 ◽  
Vol Volume 16 ◽  
pp. 1457-1470
Author(s):  
Xinning Wang ◽  
Qiang Zu ◽  
Jinshan Lu ◽  
Lei Zhang ◽  
Qiang Zhu ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Transplantation ◽  
Age Difference ◽  
Recipient Age

Impact of donor and recipient age difference on long-term allograft survival after living donor renal transplantation: analysis of 478 cases

2013 ◽  
Vol 27 (6) ◽  
pp. 838-843 ◽  
Author(s):  
Ioannis D. Kostakis ◽  
Demetrios N. Moris ◽  
Alexandros Barlas ◽  
Ioannis Bokos ◽  
Maria Darema ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Living Donor ◽  
Age Difference ◽  
Allograft Survival ◽  
Recipient Age

Trajectories and Predictors of Allograft Dysfunction after Renal Transplantation in Children

2016 ◽  
Vol 45 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Vandréa Carla de Souza ◽  
Muriel Rabilloud ◽  
Pierre Cochat ◽  
Mario Bernardes Wagner ◽  
Clotilde Druck Garcia ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Transplant ◽  
Latent Class ◽  
Latent Class Model ◽  
Survival Rates ◽  
Deceased Donor ◽  
Age Difference ◽  
Allograft Function ◽  
Recipient Age

Background: The survival rates of renal transplant children are indeed on the rise, but it is still important to ensure that there is optimal renal function in these children in all their future growing years. The number of functioning nephrons and the graft ability to adapt to an increasing demand during body growth seem to be the most important factors for long-term allograft function. This study examined the long-term change in the glomerular filtration rate in a pediatric kidney transplant cohort and the importance of the recipient and donor ages in predicting transplant outcome. Methods: Data on 67 renal transplant children who underwent 278 inulin-clearance measurements between 2000 and 2010 were examined. A longitudinal latent class model was used to identify renal function trajectories and classify the children. Results: This model identified 3 trajectories of renal allograft function after pediatric kidney transplantation: ‘low and decreasing', ‘moderate and stable', and ‘high and sharply decreasing'. The probability of belonging to the low and decreasing trajectory - that is, the poorer outcome - was lower in recipients of grafts from living versus deceased donor (adjusted OR (aOR) 0.02; p = 0.03). This probability increased with recipient age (aOR 1.20 per year of recipient ageing; p = 0.07) and donor-recipient age-difference (aOR 1.13 per additional year; p = 0.07). Conclusion: This study suggests that donation from living donors and from younger donors are favorable factors for long-term allograft function.

scholarly journals P1619OUTCOME OF HIGH DONOR-RECIPIENT AGE GAP IN LIVE-DONOR RENAL TRANSPLANTS IN TACROLIMUS ERA

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Hatem Kaies Ibrahim Elsayed Ali ◽  
Ahmed Daoud ◽  
Karim Soliman ◽  
Mahmoud Mohamed ◽  
Asam Murtaza
Keyword(s):  
Renal Transplant ◽  
Acute Rejection ◽  
Graft Survival ◽  
Age Difference ◽  
Live Donor ◽  
Renal Transplants ◽  
Transplant Patients ◽  
Age Gap ◽  
Group A ◽  
Recipient Age

Abstract Background and Aims High donor-recipient age gap among deceased-donor renal transplant patients leads to worse outcomes. However, the impact of this gap among live-donor renal transplants is unclear. The aim of this study is to assess the effect of this age gap on graft survival and acute rejection rates among renal transplants in tacrolimus era. Method 14390 live-donor renal transplant patients who received a single organ transplant, had no previous renal transplants, discharged on tacrolimus-based immunotherapy and were registered in the Organ Procurement Transplantation Network from January 2000 till June 2017 were included in the study. Donor–recipient age difference was divided into 5 groups; group A (difference <−10,n=4375), group B (difference from -10 to 10,n=7229), group C (difference between 10-20, n=861), group D ( difference between 20–29, n=1406) and group E (difference ≥30 years, n=519). Poisson regression analysis was used to assess effect of age gap on acute rejection rates. Kaplan-Meier survival curves and Cox hazard regression analysis were used to assess this effect on graft survival. Results Regarding graft survival, groups with age difference ≥30 years and between 20-29 years showed a significantly higher risk of graft loss when compared to group with age difference <−10 (HR equals 4.6 and 3.8 respectively). Groups with age difference between 10 to 20 years and between -10 to 10 years showed no significant difference in graft survival when compared to same group (HR equals 1.03 and 0.95 respectively). Groups B,C,D,E were not associated with increased risk of acute rejection episodes when compared to group A (IRR=1.001, 1.001, 1.022, 1.027 respectively). Conclusion Donor-recipient age difference up to 20 years has similar renal transplant outcomes to those receiving kidneys from younger donors and therefore, should not be precluded from paired kidney donation programs. The donor-recipient age difference above 20 years is associated with worse outcomes in terms of graft survival.

Early measurement of interstitial fibrosis predicts long-term renal function and graft survival in renal transplantation

1996 ◽  
Vol 83 (8) ◽  
pp. 1082-1085 ◽  
Author(s):  
M. L. Nicholson ◽  
T. A. McCulloch ◽  
S. J. Harper ◽  
T. J. Wheatley ◽  
C. M. Edwards ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Transplantation ◽  
Graft Survival ◽  
Interstitial Fibrosis ◽  
Early Measurement

scholarly journals Predictors and Evolution of Renal Function during 9 Years Following Heart Transplantation

2000 ◽  
Vol 11 (5) ◽  
pp. 951-957
Author(s):  
BJÖRN LINDELÖW ◽  
CLAES-HÅKAN BERGH ◽  
HANS HERLITZ ◽  
FINN WAAGSTEIN
Keyword(s):  
Renal Function ◽  
Heart Transplantation ◽  
Cyclosporin A ◽  
Renal Dysfunction ◽  
University Hospital ◽  
Channel Blockers ◽  
Converting Enzyme Inhibitors ◽  
Preoperative Serum ◽  
Recipient Age ◽  
Severe Renal Dysfunction

Abstract. Over a 9-yr period, heart transplantation was performed in 200 patients at Sahlgrenska University Hospital. Of these 200 patients, 151 were followed for 1 to 9 yr with regard to renal function, hemodynamics, cyclosporin A concentrations, and complications. Patients with a preoperative serum creatinine >130 μmol/L received inotropic drugs to test for reversibility of renal dysfunction. The end point was graft failure. The average preoperative GFR of 66 ± 17 ml/min per 1.73 m2 declined to 52 ± 19, 44 ± 16, and 37 ± 17 at 1, 5, and 9 yr after heart transplantation, respectively. Altogether, the average GFR declined by 44%. There was no significant correlation between the preoperative GFR and postoperative renal function or survival. Recipient age was a predictor of renal function during the entire follow-up. Severe renal dysfunction (GFR <20 ml/min per 1.73 m2) developed in 20% of the patients, which was predicted by the recipient age at transplantation together with the GFR 1 yr after transplantation. A nomogram that shows the risk of developing severe renal dysfunction after heart transplantation is presented. Cyclosporin A concentrations and treatment with statins, calcium channel blockers, or angiotensin-converting enzyme inhibitors did not correlate with the evolution of renal function. Patients with a preoperative depressed renal function who improved on inotropic treatment seemed to have a poorer outcome compared with the other study patients.

Longterm renal function protection in renal transplantation by nonimmunological treatments

1997 ◽  
pp. 167-174
Author(s):  
François Berthoux ◽  
Salem El Deeb ◽  
Eric Alamartine ◽  
Jean-Pierre De Filippis ◽  
Nabil Diab
Keyword(s):  
Renal Function ◽  
Renal Transplantation
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