scholarly journals Human Adipose Tissue-Derived Mesenchymal Stem Cells in Parkinson’s Disease: Inhibition of T Helper 17 Cell Differentiation and Regulation of Immune Balance Towards a Regulatory T Cell Phenotype

2020 ◽  
Vol Volume 15 ◽  
pp. 1383-1391
Author(s):  
Yong Bi ◽  
Xiaobin Lin ◽  
Huazheng Liang ◽  
Dehao Yang ◽  
Xiaowei Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Cell Differentiation ◽  
Human Adipose Tissue ◽  
Cell Phenotype ◽  
T Helper ◽  
T Helper 17 ◽  
Immune Balance ◽  
T Helper 17 Cell

scholarly journals Human Adipose Tissue-Derived Mesenchymal Stem Cells Abrogate Plasmablast Formation and Induce Regulatory B Cells Independently of T Helper Cells

Stem Cells ◽  
2015 ◽  
Vol 33 (3) ◽  
pp. 880-891 ◽  
Author(s):  
M. Franquesa ◽  
F. K. Mensah ◽  
R. Huizinga ◽  
T. Strini ◽  
L. Boon ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
B Cells ◽  
T Helper Cells ◽  
Human Adipose Tissue ◽  
Regulatory B Cells ◽  
T Helper ◽  
Helper Cells

scholarly journals Conditioned Medium from Adipose Tissue-Derived Mesenchymal Stem Cells Induces CD4+FOXP3+ Cells and Increases IL-10 Secretion

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Ekaterina Ivanova-Todorova ◽  
Ivan Bochev ◽  
Rumen Dimitrov ◽  
Kalina Belemezova ◽  
Milena Mourdjeva ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
T Helper Cells ◽  
T Regulatory Cells ◽  
Human Adipose Tissue ◽  
T Helper ◽  
Helper Cells ◽  
Immunoregulatory Cells ◽  
T Helpers

Mesenchymal stem cells (MSCs) are a new and promising tool for therapy of autoimmune disorders. In recent years their possibility to take part in the modulation of the immune response is discussed. The exact mechanisms for immunoregulation realized by MSCs are not clear yet, but interactions with other immunoregulatory cells may be involved in this process. The investigation of the influence of MSCs on the expression of FoxP3 and cytokine secretion by T helper cells was the aim of this study. T helper cells were isolated from PBMCs by magnetic separation and MSCs were isolated from human adipose tissue, and CD4+ T cells were cultured with conditional medium of MSCs. The methods which were used include flow cytometry, ELISA, and Human Proteome profiler kits. The results demonstrated that secretory factors in MSCs conditional medium lead to increased expression of FoxP3 and increased secretion of IL-10 by T helpers. The obtained results give us opportunity to discuss the interaction between two kinds of immunoregulatory cells: MSCs and FoxP3+ T helpers. We suppose that this interaction leads to increased number of immunosuppressive helpers which secrete IL-10. MSCs provide some of their immunosuppressive functions acting on T regulatory cells, and we believe that IL-6 secreted by MSCs is involved in this process.

In VitroSimulation of Corneal Epithelium Microenvironment Induces a Corneal Epithelial-like Cell Phenotype from Human Adipose Tissue Mesenchymal Stem Cells

2013 ◽  
Vol 38 (9) ◽  
pp. 933-944 ◽  
Author(s):  
Teresa Nieto-Miguel ◽  
Sara Galindo ◽  
Roberto Reinoso ◽  
Alfredo Corell ◽  
Mario Martino ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Corneal Epithelium ◽  
Human Adipose Tissue ◽  
Cell Phenotype ◽  
Corneal Epithelial

Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo

Gut ◽  
2008 ◽  
Vol 58 (4) ◽  
pp. 570-581 ◽  
Author(s):  
H Aurich ◽  
M Sgodda ◽  
P Kaltwasser ◽  
M Vetter ◽  
A Weise ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Human Adipose Tissue ◽  
Hepatocyte Differentiation ◽  
Adipose Tissue In Vitro

Prostaglandins Differentially Affect Osteogenic Differentiation of Human Adipose Tissue–Derived Mesenchymal Stem Cells

2007 ◽  
Vol 13 (10) ◽  
pp. 2495-2503 ◽  
Author(s):  
M. Knippenberg ◽  
M.N. Helder ◽  
J.M.A. de Blieck-Hogervorst ◽  
P.I.J.M. Wuisman ◽  
J. Klein-Nulend
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Osteogenic Differentiation ◽  
Human Adipose Tissue
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