scholarly journals Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study

2018 ◽  
Vol Volume 13 ◽  
pp. 2503-2509 ◽  
Author(s):  
Huijun Chen ◽  
Yuntao Liu ◽  
Guiqian Huang ◽  
Jie Zhu ◽  
Wenqian Feng ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Ischemic Stroke ◽  
Cognitive Impairment ◽  
Acute Ischemic Stroke ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Vitamin D Status ◽  
Stroke Patients

Serum Periostin and Cognitive Impairment in Ischemic Stroke Patients: a Prospective Cohort Study

2021 ◽  
Author(s):  
Guangzong Li ◽  
Jie Li ◽  
Chen Zhu ◽  
Jing Ye ◽  
Bin Wang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Ischemic Stroke ◽  
Cognitive Impairment ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Enzyme Linked Immunosorbent Assay ◽  
Stroke Severity ◽  
Stroke Patients ◽  
Increased Risk ◽  
Serum Periostin

Abstract Background. Recent evidence suggest elevated periostin is associated with cardiovascular diseases. The aim of this study was to investigate the relationship between serum periostin and post-stroke cognitive impairment (PSCI) at 3 months. Methods. In this prospective cohort study, we enrolled patients with ischemic stroke and hospitalized within 7 days of symptoms onset from January 2019 to January 2020. Serum periostin levels were measured using enzyme-linked immunosorbent assay after admission. Cognitive function assessment was performed at 3-month follow-up visit using the Montreal Cognitive Assessment (MoCA). We defined the PSCI as total MoCA score < 25. Results. A total of 315 ischemic stroke patients were enrolled for the study. PSCI was observed in 173 patients, which accounted for 54.9% (95% confidence interval [CI] 52.1%–57.7%) of the cohort. Serum periostin levels were higher in patients with PSCI than in those without PSCI (median 19.6 vs 14.8 ng/mL; P = 0.001). In logistic regression analysis, the highest quartile of periostin levels were significantly correlated to PSCI (odds ratio [OR], 9.69; 95% CI, 5.06–25.61; P = 0.001), as compared with the lowest quartile. This association remained significant after adjustment for age, gender, educational years, stroke severity, and vascular risk factors. Subgroup analyses further confirmed these results. Furthermore, restricted cubic spline regression demonstrated a linear association between periostin levels and PSCI (P = 0.001 for linearity).Conclusions. This study found that higher serum periostin levels are associated with an increased risk of PSCI at 3 months after ischemic stroke onset.

Modified 8Ds algorithm improves door-to-needle time in patients with acute ischemic stroke eligible for alteplase or thrombectomy: A prospective Cohort study

2021 ◽  
Vol 429 ◽  
pp. 119710
Author(s):  
Mojdeh Ghabaee ◽  
Ghasem Farahmand ◽  
Pargol Balali ◽  
Hana Magrouni ◽  
Fatemeh Alizadeh-Broujeni ◽  
...  
Keyword(s):  
Cohort Study ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Prospective Cohort Study ◽  
Prospective Cohort

Maternal Vitamin D Status During Pregnancy and Bone Mass in Offspring at 20 Years of Age: A Prospective Cohort Study

2014 ◽  
Vol 29 (5) ◽  
pp. 1088-1095 ◽  
Author(s):  
Kun Zhu ◽  
Andrew JO Whitehouse ◽  
Prue H Hart ◽  
Merci Kusel ◽  
Jenny Mountain ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Bone Mass ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Maternal Vitamin D Status
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