scholarly journals Effects of comprehensive geriatric assessment on physical fitness in an acute medical setting for frail elderly patients

2017 ◽  
Vol Volume 12 ◽  
pp. 1929-1939 ◽  
Author(s):  
Kristina Åhlund ◽  
Maria Bäck ◽  
Birgitta Öberg ◽  
Niklas Ekerstad
Keyword(s):  
Elderly Patients ◽  
Physical Fitness ◽  
Geriatric Assessment ◽  
Frail Elderly ◽  
Comprehensive Geriatric Assessment ◽  
Medical Setting

scholarly journals Is the acute care of frail elderly patients in a comprehensive geriatric assessment unit superior to conventional acute medical care?

2016 ◽  
Vol Volume 12 ◽  
pp. 1-9 ◽  
Author(s):  
Niklas Ekerstad ◽  
Björn Karlson ◽  
Synneve Dahlin Ivanoff ◽  
Sten Landahl ◽  
David Andersson ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Medical Care ◽  
Acute Care ◽  
Geriatric Assessment ◽  
Frail Elderly ◽  
Comprehensive Geriatric Assessment ◽  
Assessment Unit ◽  
Acute Medical Care

scholarly journals A randomized clinical study on the impact of Comprehensive Geriatric Assessment (CGA) based interventions on the quality of life of elderly, frail, onco-hematologic patients candidate to anticancer therapy: protocol of the ONCO-Aging study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Abdurraouf Mokhtar Mahmoud ◽  
Federica Biello ◽  
Paola Maria Maggiora ◽  
Riccardo Bruna ◽  
Giovanni Burrafato ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Elderly Patients ◽  
Geriatric Assessment ◽  
Frail Elderly ◽  
Comprehensive Geriatric Assessment ◽  
Fine Tuning ◽  
Biological Study ◽  
Plasma Samples ◽  
The Impact

Abstract Background Age is considered as one of the most important risk-factor for many types of solid and hematological cancers, as their incidence increases with age in parallel to the ever-growing elderly population. Moreover, cancer incidence is constantly increasing as a consequence of the increase in life expectancy that favors the process of cellular senescence. Geriatric assessment has been increasingly recognized as predictive and prognostic instrument to detect frailty in older adults with cancer. In particular, the G8 score is a simple and reproducible instrument to identify elderly patients who should undergo full geriatric evaluation. Due to their frailty, elderly patients may be often under-treated and a therapeutic choice based also on a comprehensive geriatric assessment (CGA) is recommended. With these premises, we aim to test the impact of the CGA based interventions on the quality of life (QoL) of frail elderly onco-hematological patients, identified by the G8 screening, candidate for innovative target directed drugs or treatments including the combination of radiotherapy and chemotherapy (RT + CT). Methods Patients aged > 65 years, candidate to target directed agents or to RT + CT treatments are screened for frailty by the G8 test; those patients classified as frail (G8 ≤ 14) are randomized to receive a CGA at baseline or to conventional care. The primary endpoint is QoL, assessed by EORTC QLQ-C30C. As collateral biological study, the potential prognostic/predictive role of T-cell senescence and myeloid derived suppressor cells (MDSC) are evaluated on plasma samples. Discussion This trial will contribute to define the impact of CGA on the management of frail elderly onco-hematologic patients candidate to innovative biological drugs or to integrated schedules with the association of RT + CT. Furthermore, the use of plasma samples to assess the potential prognostic value of imbalance of immune-competent cells is expected to contribute to the individualized care of elderly patients, resulting into a fine tuning of the therapeutic strategies. Trial registration ClinicalTrials.gov ID: NCT04478916. registered July 21, 2020 – retrospectively registered.

scholarly journals Role of anthracycline and comprehensive geriatric assessment for elderly patients with diffuse large B-cell lymphoma

Blood ◽  
2017 ◽  
Vol 130 (20) ◽  
pp. 2180-2185 ◽  
Author(s):  
Richard J. Lin ◽  
Madhusmita Behera ◽  
Catherine S. Diefenbach ◽  
Christopher R. Flowers
Keyword(s):  
Elderly Patients ◽  
B Cell ◽  
Geriatric Assessment ◽  
Comprehensive Geriatric Assessment ◽  
Cell Lymphoma ◽  
Treatment Decision ◽  
B Cell Lymphoma ◽  
Treatment Decision Making ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Abstract Survival outcome for elderly patients with newly diagnosed diffuse large B-cell lymphoma remains suboptimal in the rituximab era. In this systematic review, we summarize available evidence relevant to the inclusion of anthracycline in upfront chemoimmunotherapy for these elderly patients and highlight the need of prospective clinical trials. With limited prospective data, we find that pretreatment comprehensive geriatric assessment accurately predicts survival and treatment-related toxicities, suggesting its potential role in guiding overall treatment decision-making.

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