scholarly journals Application of an adapted PRECIS-2 instrument to assess efficacy- and effectiveness-study designs in a systematic review of intervention studies of the hepatitis C virus-care continuum among people who use drugs

2018 ◽  
Vol Volume 8 ◽  
pp. 3-17
Author(s):  
Ashly E Jordan ◽  
David C Perlman ◽  
Daniel J Smith ◽  
Holly Hagan
Keyword(s):  
Systematic Review ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Intervention Studies ◽  
People Who Use Drugs ◽  
Effectiveness Study ◽  
Care Continuum ◽  
Study Designs

scholarly journals Hepatitis C Virus (HCV) Care Continuum Outcomes and HCV Community Viral Loads Among Patients in an Opioid Treatment Program

2020 ◽  
Vol 222 (Supplement_5) ◽  
pp. S335-S345
Author(s):  
Ashly E Jordan ◽  
Charles M Cleland ◽  
Bruce R Schackman ◽  
Katarzyna Wyka ◽  
David C Perlman ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
Treatment Program ◽  
Linkage To Care ◽  
People Who Use Drugs ◽  
Treatment Need ◽  
Care Continuum ◽  
Opioid Treatment ◽  
Unmet Treatment Need

Abstract Background Hepatitis C virus (HCV) remains endemic among people who use drugs (PWUD). Measures of HCV community viral load (CVL) and HCV care continuum outcomes may be valuable for ascertaining unmet treatment need and for HCV surveillance and control. Methods Data from patients in an opioid treatment program during 2013–2016 were used to (1) identify proportions of antibody and viral load (VL) tested, linked-to-care, and treated, in 2013–2014 and 2015–2016, and pre- and postimplementation of qualitative reflex VL testing; (2) calculate engaged-in-care HCV CVL and “documented” and “estimated” unmet treatment need; and (3) examine factors associated with linkage-to-HCV-care. Results Among 11 267 patients, proportions of HCV antibody tested (52.5% in 2013–2014 vs 73.3% in 2015–2016), linked-to-HCV-care (15.7% vs 51.8%), and treated (12.0% vs 44.7%) all increased significantly. Hispanic ethnicity was associated with less linkage-to-care, and Manhattan residence was associated with improved linkage-to-care. The overall engaged-in-care HCV CVL was 4 351 079 copies/mL (standard deviation = 7 149 888); local HCV CVLs varied by subgroup and geography. Documented and estimated unmet treatment need decreased but remained high. Conclusions After qualitative reflex VL testing was implemented, care continuum outcomes improved, but gaps remained. High rates of unmet treatment need suggest that control of the HCV epidemic among PWUD will require expansion of HCV treatment coverage.

Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review

2016 ◽  
Vol 17 (13) ◽  
pp. 1560-1576 ◽  
Author(s):  
Yuanchao Xie ◽  
Comfort Alicha Ogah ◽  
Xiangrui Jiang ◽  
Jianfeng Li ◽  
Jingshan Shen
Keyword(s):  
Systematic Review ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Nucleoside Inhibitors ◽  
Ns5b Polymerase

scholarly journals 1159 SEQUENCING THE HEPATITIS C VIRUS: A SYSTEMATIC REVIEW

2013 ◽  
Vol 58 ◽  
pp. S471-S472
Author(s):  
B. Jacka ◽  
F. Lamoury ◽  
P. Simmonds ◽  
G.J. Dore ◽  
J. Grebely ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hepatitis C Virus ◽  
Hepatitis C
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