scholarly journals Rindopepimut: an evidence-based review of its therapeutic potential in the treatment of EGFRvIII-positive glioblastoma

Core Evidence ◽  
2012 ◽  
pp. 93 ◽  
Author(s):  
Cory Adamson ◽  
Babu
Keyword(s):  
Therapeutic Potential ◽  
Evidence Based

Evidence-Based Pharmacotherapy for Cocaine, Amphetamine, and Methamphetamine Use Disorders

2020 ◽  
pp. 283-306
Author(s):  
Xuefeng Zhang ◽  
Thomas R. Kosten
Keyword(s):  
Clinical Trials ◽  
Behavioral Interventions ◽  
Therapeutic Potential ◽  
Supportive Therapy ◽  
Evidence Based ◽  
Methamphetamine Use ◽  
The Us ◽  
Initial Recovery ◽  
Early Phase Clinical Trials ◽  
New Strategies

Cocaine use disorder is one of the important stimulants use disorders worldwide, and amphetamine/methamphetamine misuse is a growing epidemic. There are no pharmacotherapy treatments approved by the US Food and Drug Administration (FDA) available for these illnesses. Numerous treatments based on a variety of strategies from psychotherapy, pharmacotherapy, to neuromodulation have been tested to date. Clinical efficacy of the trialed treatments, including both negative and positive outcomes. are reviewed and discussed in this chapter. In summary, many agents and interventions showed promising therapeutic potential in preclinical and early phase clinical trials but eventually failed in later larger trials. Thus, behavioral interventions and supportive therapy focusing on detoxification, initial recovery, and relapse prevention remain the major therapeutic approach due to lack of targeted treatment. New strategies and models are urgently needed to develop effective treatments for these detrimental disorders.

scholarly journals The Interrelationships between Intestinal Permeability and Phlegm Syndrome and Therapeutic Potential of Some Medicinal Herbs

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 284
Author(s):  
Junghyun Park ◽  
Tae Joon Choi ◽  
Ki Sung Kang ◽  
Seo-Hyung Choi
Keyword(s):  
Public Health ◽  
Therapeutic Potential ◽  
Synergistic Effects ◽  
Critical Role ◽  
The Body ◽  
Future Research ◽  
Evidence Based ◽  
Leaky Gut ◽  
Gi Tract ◽  
Phlegm Syndrome

The gastrointestinal (GI) tract has an intriguing and critical role beyond digestion in both modern and complementary and alternative medicine (CAM), as demonstrated by its link with the immune system. In this review, we attempted to explore the interrelationships between increased GI permeability and phlegm, an important pathological factor in CAM, syndrome, and therapeutic herbs for two disorders. The leaky gut and phlegm syndromes look considerably similar with respect to related symptoms, diseases, and suitable herbal treatment agents, including phytochemicals even though limitations to compare exist. Phlegm may be spread throughout the body along with other pathogens via the disruption of the GI barrier to cause several diseases sharing some parts of symptoms, diseases, and mechanisms with leaky gut syndrome. Both syndromes are related to inflammation and gut microbiota compositions. Well-designed future research should be conducted to verify the interrelationships for evidence based integrative medicine to contribute to the promotion of public health. In addition, systems biology approaches should be adopted to explore the complex synergistic effects of herbal medicine and phytochemicals on conditions associated with phlegm and leaky gut syndromes.

scholarly journals The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines

Gut ◽  
2018 ◽  
Vol 67 (11) ◽  
pp. 1920-1941 ◽  
Author(s):  
Benjamin H Mullish ◽  
Mohammed Nabil Quraishi ◽  
Jonathan P Segal ◽  
Victoria L McCune ◽  
Melissa Baxter ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Therapeutic Potential ◽  
Evidence Base ◽  
British Society ◽  
Evidence Based ◽  
Faecal Microbiota ◽  
Guideline Document ◽  
Nice Guidance ◽  
Potential Applications ◽  
The Uk

Interest in the therapeutic potential of faecal microbiota transplant (FMT) has been increasing globally in recent years, particularly as a result of randomised studies in which it has been used as an intervention. The main focus of these studies has been the treatment of recurrent or refractory Clostridium difficile infection (CDI), but there is also an emerging evidence base regarding potential applications in non-CDI settings. The key clinical stakeholders for the provision and governance of FMT services in the UK have tended to be in two major specialty areas: gastroenterology and microbiology/infectious diseases. While the National Institute for Health and Care Excellence (NICE) guidance (2014) for use of FMT for recurrent or refractory CDI has become accepted in the UK, clear evidence-based UK guidelines for FMT have been lacking. This resulted in discussions between the British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS), and a joint BSG/HIS FMT working group was established. This guideline document is the culmination of that joint dialogue.

Imidazole: An emerging scaffold showing its therapeutic voyage to develop valuable molecular entities

2019 ◽  
Vol 11 ◽  
Author(s):  
Bhawna Chopra ◽  
Ashwani K. Dhingra ◽  
Deo Nandan Prasad
Keyword(s):  
Drug Development ◽  
Therapeutic Potential ◽  
Present Review ◽  
Evidence Based ◽  
Pharmacological Agents ◽  
New Class ◽  
Heterocyclic Molecules ◽  
Biological Potential ◽  
New Drug Development ◽  
Heterocyclic Moiety

Objective: Imidazole is a heterocyclic moiety having immense biological importance. Since from ancient years, imidazole nucleus was found to be promising moiety in field of chemistry. Preliminaryin vitroand in vivostudies have provided valuable scientific evidencefor its use. Subsequently, imidazole constitutes for new class of compounds for new drug development as presence of this nucleus in diverse therapeutic categories viz; antimicrobial, anti-inflammatory, anticancer, immunomodulator, antiviral etchas made it an interesting moiety for design and development of new pharmacological agents. Thus this review aims to summarize the reported molecular entities which were synthesized by using conventional as well as microwave processes, chemistry and biological potential of imidazole containing heterocyclic molecules while identifying potential areas of further research of imidazole. Key findings: The review comprises literature pertaining to the evidence based pharmacological or therapeutic potential of imidazole from may many years using published articles and worldwide databases. Various pharmacological experiments using different models exclusively proven the potential of imidazole. Summary: Thus, focusing on discovery and development of new imidazole nucleus based molecules at a faster rate; there is a need to check out the previous information available in market in the field of medicinal chemistry. So the present review aims ornately pronounced the therapeutic worth of imidazole and its analogs.

scholarly journals Therapeutic Potential of Widely Used Unani Drug Asl-Us-Soos (Glycyrrhiza glabra Linn.): A Systematic Review

2019 ◽  
Vol 9 (4-s) ◽  
pp. 765-773
Author(s):  
Ahmad Ishtiyaq ◽  
ABRAR ALAM ◽  
Javed Inam Siddiqui ◽  
Munawwar Husain Kazmi
Keyword(s):  
Therapeutic Potential ◽  
Current Knowledge ◽  
Holistic Approach ◽  
Antimycobacterial Activity ◽  
Morphological Characters ◽  
Glycyrrhiza Glabra ◽  
Clinical Approach ◽  
Evidence Based ◽  
Traditional System ◽  
Health Products

Plants have been one of the important sources of therapeutics or other human health benefits  since the beginning of human civilization throughout history. Currently, there is increasing awareness and general acceptability of the use of herbs, as a medicines, health products, pharmaceuticals, food supplements, cosmetics etc. Traditional system of medicine including Ayurveda, Unani, and Siddha etc. contributed in Health care dealing worldwide. The Unani system of medicine (USM) is an age old system of medicine which has a holistic approach to treat various kind of disease; most of the time the drugs mentioned in this system has tremendous effects in chronic disease. Asl-Us-Soos (Glycyrrhiza glabra Linn), is a widely used herb in USM. Although the review articles on this plant are already published, this review article is presented to comply all the updated information on its therapeutic potency based on phytoconstituents and pharmacological activities and the potency which is described by renowned Unani physicians and scholars. The evidence based studies provides strengthen to the concept of Unani physicians as the Unani physician used and recommended the drug since along. Moreover the evidence based studies indicate that Glycyrrhiza glabra Linn possesses antibacterial, antioxidant, antimalarial, antispasmodic, expectorant, aphrodisiac, antimycobacterial activity, antiinflammatory and anti-hyper glycemic properties. Various other effects like antiulcer, antiviral, antihepatotoxic, antifungal and herpes simplex have also been studies. These results are very encouraging and indicate that this Unani drug can be studies more extensively with a well-planned and systematic scientific preclinical and clinical approach to explore the promising outcome. Further this review gives an account of the current knowledge on the morphological characters, microscopic characters, phytochemistry, and pharmacological actions present in root of Glycyrrhiza glabra along with its actions and therapeutic potential in the perspective of USM. Keywords: Glycyrrhiza glabra, therapeutic potential, USM

Therapeutic potential of α-glucosidase inhibitors in type 2 diabetes mellitus: an evidence-based review

2015 ◽  
Vol 16 (13) ◽  
pp. 1959-1981 ◽  
Author(s):  
Shashank R Joshi ◽  
Eberhard Standl ◽  
Nanwei Tong ◽  
Parag Shah ◽  
Sanjay Kalra ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Therapeutic Potential ◽  
Evidence Based ◽  
Glucosidase Inhibitors

scholarly journals Addressing Spiritual and Religious Coping in Psychotherapy An Overview of the Western Studies

2016 ◽  
Vol 24 (5) ◽  
pp. 151-177
Author(s):  
F.M. Shankov
Keyword(s):  
Religious Coping ◽  
Therapeutic Potential ◽  
Spiritual Coping ◽  
Evidence Based ◽  
The West ◽  
Beliefs And Practices ◽  
Abstract Level ◽  
Behavioristic Approach ◽  
Spiritual And Religious Coping ◽  
Empirical Foundation

Spiritual and religious beliefs and practices contain an enormous therapeutic potential, which is shown by research held in the West. What prevents therapists from addressing this sphere with their clients? What are the barriers, strategies and conditions of integrating spiritual into psychotherapy? The scientific and empirical foundation of research analyzed in current paper gives an example ofan alternative to unproductive discussions on an abstract level in ideological-confrontational style on the evidence based and scientific level. The positive and negative side of such instrumental and behavioristic approach to spirituality is outlined. A task of generating a whole and methodologically funded model of the process of spiritual coping is beingraised.

Evaluation of the Efficacy and Safety of Topical Imiquimod 5% for Plaque-Type Morphea: A Multicenter, Prospective, Vehicle-Controlled Trial

2015 ◽  
Vol 19 (2) ◽  
pp. 132-139 ◽  
Author(s):  
Marlene Dytoc ◽  
Heidi Wat ◽  
Melody Cheung-Lee ◽  
Douglas Sawyer ◽  
Thomas Ackerman ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Treatment Efficacy ◽  
Therapeutic Potential ◽  
Controlled Trial ◽  
Evidence Based ◽  
Efficacy And Safety ◽  
Plaque Type ◽  
Ultrasound Evaluation ◽  
Histologic Evaluation ◽  
Diet Score

Background There is currently a lack of evidence-based therapies that are safe and effective for plaque-type morphea. We aimed to evaluate the therapeutic potential and safety profile of imiquimod 5% cream in plaque-type morphea. Methods We enrolled 25 adult patients from two Canadian centers with histologically confirmed plaque-type morphea. Imiquimod 5% was applied to a representative plaque, and vehicle was applied to a control plaque for 9 months. Treatment efficacy was assessed with the Dyspigmentation, Induration, Erythema, and Telangiectasias (DIET) score, histology, and ultrasound evaluation. Results and Conclusions Twenty-two patients completed the entire length of the study. Imiquimod 5% was superior to vehicle in reducing DIET scores at 3, 6, 9, and 12 months ( p < .05). Induration demonstrated the greatest response. Histologic evaluation showed significant improvement or resolution of disease. However, no ultrasonographic differences were found in dermal and hypodermal thicknesses between the treatment and vehicle groups ( p > .05). Adverse effects were minimal and well tolerated.

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