scholarly journals An evidence-based review of the potential role of icatibant in the treatment of acute attacks in hereditary angioedema type I and II

Core Evidence ◽  
2012 ◽  
pp. 105 ◽  
Author(s):  
Bernard Floccard ◽  
Hautin ◽  
Laurence Bouillet ◽  
Coppere ◽  
Allaouchiche
Keyword(s):  
Hereditary Angioedema ◽  
Potential Role ◽  
Evidence Based ◽  
Type I ◽  
Acute Attacks

scholarly journals Subclinical Signs of Retinal Involvement in Hereditary Angioedema

2021 ◽  
Vol 10 (22) ◽  
pp. 5415
Author(s):  
Paola Triggianese ◽  
Matteo Di Marino ◽  
Carolina Nesi ◽  
Elisabetta Greco ◽  
Stella Modica ◽  
...  
Keyword(s):  
Hereditary Angioedema ◽  
Potential Role ◽  
Case Control Study ◽  
Capillary Density ◽  
Posterior Pole ◽  
Type I ◽  
Fiber Layer ◽  
Control Study ◽  
Sd Oct

To explore retinal abnormalities using spectral domain optical coherence tomography (SD-OCT) and OCT-angiography (OCT-A) in a highly selective cohort of patients with type I hereditary angioedema (HAE). This prospective case-control study included 40 type I HAE patients and 40 age-/sex-matched healthy subjects (HC). All participants underwent SD-OCT-scanning of retinal posterior pole (PP), peripapillary retinal nerve fiber layer (pRNFL), and optic nerve head (ONH). Superficial/deep capillary density was analyzed by OCT-A. A total of 80 eyes from 40 HAE and 40 eyes from HC were evaluated. The pRNFL was thicker in HAE than in HC in nasal superior (p < 0.0001) and temporal quadrants (p = 0.0005 left, p = 0.003 right). The ONH thickness in HAE patients was greater than in HC in the nasal (p = 0.008 left, p = 0.01 right), temporal (p = 0.0005 left, p = 0.003 right), temporal inferior (p = 0.007 left, p = 0.0008 right), and global (p = 0.005 left, p = 0.007 right) scans. Compared to HC, HAE showed a lower capillary density in both superficial (p = 0.001 left, p = 0.006 right) and deep (p = 0.008 left, p = 0.004 right) whole images, and superficial (p = 0.03 left) and deep parafoveal (p = 0.007 left, p = 0.005 right) areas. Our findings documented subclinical retinal abnormalities in type I HAE, supporting a potential role of the retinal assessment by SD-OCT/OCT-A as a useful tool in the comprehensive care of HAE patients.

scholarly journals An Evidence-Based Multidisciplinary Approach to the Management of Hepatocellular Carcinoma (HCC): The Alberta HCC Algorithm

2010 ◽  
Vol 24 (11) ◽  
pp. 643-650 ◽  
Author(s):  
Kelly W Burak ◽  
Norman M Kneteman
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Liver Function ◽  
Potential Role ◽  
Staging System ◽  
Evidence Based ◽  
Transarterial Radioembolization ◽  
Bclc Staging ◽  
Tumour Characteristics

Hepatocellular carcinoma (HCC) is one of only a few malignancies with an increasing incidence in North America. Because the vast majority of HCCs occur in the setting of a cirrhotic liver, management of this malignancy is best performed in a multidisciplinary group that recognizes the importance of liver function, as well as patient and tumour characteristics. The Barcelona Clinic Liver Cancer (BCLC) staging system is preferred for HCC because it incorporates the tumour characteristics (ie, tumour-node-metastasis stage), the patient’s performance status and liver function according to the Child-Turcotte-Pugh classification, and then links the BCLC stage to recommended therapeutic interventions. However, the BCLC algorithm does not recognize the potential role of radiofrequency ablation for very early stage HCC, the expanding role of liver transplantation in the management of HCC, the role of transarterial chemoembolization in single large tumours, the potential role of transarterial radioembolization with90Yttrium and the limited evidence for using sorafenib in Child-Turcotte-Pugh class B cirrhotic patients. The current review article presents an evidence-based approach to the multidisciplinary management of HCC along with a new algorithm for the management of HCC that incorporates the BCLC staging system and the authors’ local selection criteria for resection, ablative techniques, liver transplantation, transarterial chemoembolization, transarterial radioembolization and sorafenib in Alberta.

Potential role of type I interferons in the treatment of pituitary adenomas

2008 ◽  
Vol 10 (2) ◽  
pp. 125-133 ◽  
Author(s):  
Giovanni Vitale ◽  
Michele Caraglia ◽  
Peter M. van Koetsveld ◽  
Paola Maroni ◽  
Monica Marra ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Potential Role ◽  
Type I Interferons ◽  
Type I

The potential role of soyfoods in weight and adiposity reduction: an evidence-based review

2008 ◽  
Vol 9 (3) ◽  
pp. 219-235 ◽  
Author(s):  
M. B. Cope ◽  
J. W. Erdman Jr ◽  
D. B. Allison
Keyword(s):  
Potential Role ◽  
Evidence Based

scholarly journals 5-HT and GABA Modulate Intrinsic Excitability of Type I Interneurons in Hermissenda

2009 ◽  
Vol 102 (5) ◽  
pp. 2825-2833 ◽  
Author(s):  
Nan Ge Jin ◽  
Lian-Ming Tian ◽  
Terry Crow
Keyword(s):  
Hair Cells ◽  
Spike Activity ◽  
Potential Role ◽  
Neuronal Excitability ◽  
Intrinsic Excitability ◽  
Resting Membrane Potential ◽  
Type I ◽  
Outward Currents

The sensory neurons (photoreceptors) in the visual system of Hermissenda are one site of plasticity produced by Pavlovian conditioning. A second site of plasticity produced by conditioning is the type I interneurons in the cerebropleural ganglia. Both photoreceptors and statocyst hair cells of the graviceptive system form monosynaptic connections with identified type I interneurons. Two proposed neurotransmitters in the graviceptive system, serotonin (5-HT) and γ-aminobutyric acid (GABA), have been shown to modify synaptic strength and intrinsic neuronal excitability in identified photoreceptors. However, the potential role of 5-HT and GABA in plasticity of type I interneurons has not been investigated. Here we show that 5-HT increased the peak amplitude of light-evoked complex excitatory postsynaptic potentials (EPSPs), enhanced intrinsic excitability, and increased spike activity of identified type Ie(A) interneurons. In contrast, 5-HT decreased spike activity and intrinsic excitability of type Ie(B) interneurons. The classification of two categories of type Ie interneurons was also supported by the observation that 5-HT produced opposite effects on whole cell steady-state outward currents in type Ie interneurons. Serotonin produced a reduction in the amplitude of light-evoked complex inhibitory PSPs (IPSPs), increased spontaneous spike activity, decreased intrinsic excitability, and depolarized the resting membrane potential of identified type Ii interneurons. In contrast to the effects of 5-HT, GABA produced inhibition in both types of Ie interneurons and type Ii interneurons. These results show that 5-HT and GABA can modulate the intrinsic excitability of type I interneurons independent of the presynaptic effects of the same transmitters on excitability and synaptic efficacy of photoreceptors.

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