scholarly journals Effect of TNF-α −308G/A (rs1800629) Promoter Polymorphism on the Serum Level of TNF-α Among Iraqi Patients with Generalized Vitiligo

2020 ◽  
Vol Volume 13 ◽  
pp. 825-835
Author(s):  
Ronak Ahmed ◽  
Dana Sharif ◽  
Mohammad Jaf ◽  
Dashty Mohammed Amin
Keyword(s):  
Serum Level ◽  
Promoter Polymorphism ◽  
Tnf Α

Genetic Variation in TNF-α, its Relation with Inflammatory Biomarkers and Susceptibility to Rheumatoid Arthritis

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Khadiga Ahmed Ismail
Keyword(s):  
Rheumatoid Arthritis ◽  
Serum Level ◽  
Functional Disability ◽  
Serum Levels ◽  
Amplification Refractory Mutation System ◽  
Reactive Protein ◽  
Tnf Α ◽  
Mutation System ◽  
Potential Factor ◽  
Factor Α

Background: Tumor necrosis Factor-α (TNF-α) is encoded and controlled by TNF-α gene, which is involved in rheumatoid arthritis (RA) susceptibility. This research aimed to identify genetic variations of TNF-α (G308A) and to establish its association with inflammatory markers in Rheumatoid Arthritis predisposition. Methods: In the present study, fifty RA patients and fifty volunteers were involved and evaluated for the C-reactive protein, rheumatoid factor, and TNF-α were estimated by ELISA, Erythrocyte Sedimentation Rate (ESR) by Wintergreen method and for TNF-α-308 G>A polymorphism by polymerase chain reaction with amplification refractory mutation system (PCR-ARMS). Results: The CRP, RF, ESR and TNF-α were significantly elevated in RA patients relative to controls. The serum level TNF-α was also significantly elevated in female patients and in patients ≥50 years. Analysis of TNF-308 gene polymorphism revealed that GG genotypes were more prevalent in RA patients than in the healthy individuals and that GG genotype may be a potential factor to RA. The G allele was more common in RA than in the control. Elevated TNF-α serum levels were significantly associated the GG genotype and functional disability in RA patients. Conclusion: TNF-α promoter 308polymorphism GG genotype may be considered as a risk factor for RA and the TNF-α serum level was significantly related to the functional disability in the disease.

Correlation between TNF-α- serum level and TNF-α -308 gene polymorphism in Iraqi patients with type 2 diabetes mellitus

Gene Reports ◽  
2021 ◽  
Vol 23 ◽  
pp. 101136
Author(s):  
Sarah Rahman Rasool ◽  
Othman Taha Qasim ◽  
Salaam Khudhur Muslem ◽  
Muataz Mohammed Al-Taee
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Level ◽  
Gene Polymorphism ◽  
Tnf Α

scholarly journals Response to Combination Therapy with Interferon Alfa-2a and Ribavirin in Chronic Hepatitis C According to a TNF-α Promoter Polymorphism

Digestion ◽  
2003 ◽  
Vol 68 (1) ◽  
pp. 1-4 ◽  
Author(s):  
U. Schiemann ◽  
J. Glas ◽  
P. Török ◽  
C. Simperl ◽  
K. Martin ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Combination Therapy ◽  
Chronic Hepatitis C ◽  
Promoter Polymorphism ◽  
Interferon Alfa ◽  
Tnf Α

Association between tumor necrosis factor-α gene-1031T/C promoter polymorphism and endometriosis in a European population

2019 ◽  
Vol 40 (2) ◽  
Author(s):  
Anastasia Drakou ◽  
Despoina Mavrogianni ◽  
Konstantinos Ntzeros ◽  
Athanasios Protopapas ◽  
Petros Drakakis ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Promoter Polymorphism ◽  
European Population ◽  
Pcr Analysis ◽  
Control Group ◽  
Necrosis Factor Alpha ◽  
Healthy Women ◽  
Tnf Α ◽  
Necrosis Factor

Abstract Background Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine which plays an important role in the pathogenesis of many diseases. Endometriosis is one of the most common gynecological diseases. The purpose of this study was to investigate the association of TNF-α-1031T/C polymorphism with the genetic susceptibility of endometriosis in a European population. Materials and methods In this case-control study, 51 endometriosis patients and 67 healthy control women participated. We used endometrial tissue from the patients and peripheral blood from the healthy women to extract DNA. Polymerase chain reaction (PCR) analysis and the restriction enzyme Bbs I were used to analyze the -1031 T/C polymorphism in the TNF-α gene promoter region. Statistical analysis was performed using Fisher’s exact test. We also calculated the odds ratios. Results In the group of patients, 66.7% of women were detected with the TT genotype, 33.3% with the TC genotype and 0% with the CC genotype while in the control group, 46.3% had the TT genotype, 47.8% had the TC genotype and 6% had the CC genotype. There was a significant association between the TT genotype with endometriosis (p = 0.03). There was no significant deviation from the Hardy-Weinberg equilibrium. Conclusions The TC and CC genotypes appeared more often in the healthy women than the endometriosis patients and this shows that the C allele might have a protective role in endometriosis in the Greek population. Further studies are needed to specify the role of this polymorphism in pathogenesis of endometriosis and the mechanisms that protect the patients from the disease.

scholarly journals Different Transcriptional Activity and In Vitro TNF-α Production in Psoriasis Patients Carrying the TNF-α 238A Promoter Polymorphism

2000 ◽  
Vol 114 (6) ◽  
pp. 1180-1183 ◽  
Author(s):  
Wiebke Kaluza ◽  
Esther Reuss ◽  
Sabine Grossmann ◽  
Rosula Hug ◽  
Rudolph E. Schopf ◽  
...  
Keyword(s):  
Transcriptional Activity ◽  
Promoter Polymorphism ◽  
Tnf Α

scholarly journals Association of Interleukin 6 Promoter Polymorphism (-174G/C) with IL-6 Level and Outcome in Severe Sepsis

2008 ◽  
Vol 62 (4-5) ◽  
pp. 162-164 ◽  
Author(s):  
Oļegs Sabeļnikovs ◽  
Liene Ñikitina-Zaķe ◽  
Indulis Vanags
Keyword(s):  
Severe Sepsis ◽  
Plasma Level ◽  
Serum Level ◽  
Clinical Outcome ◽  
Interleukin 6 ◽  
Promoter Polymorphism ◽  
University Hospital ◽  
Genotype Distribution ◽  
Promoter Polymorphisms ◽  
Regulatory Polymorphism

Association of Interleukin 6 Promoter Polymorphism (-174G/C) with IL-6 Level and Outcome in Severe SepsisInterleukin (IL-6) is a key cytokine in the pathogenesis of severe sepsis. The importance of a regulatory polymorphism within the IL-6 promoter remains unclear in these patients. The aim of the study was to determine if IL-6 (-174 G/C) promoter polymorphism has an effect on IL-6 plasma level and outcome of severe sepsis. The study was conducted in general ICU of Stradiñš Clinical University Hospital. A total of 103 critically ill patients with confirmed severe sepsis were prospectively included. Association analysis of the IL-6 (-174C) allele with serum level and clinical outcome was performed. We found no differences in genotype distribution between survivors and nonsurvivors. The serum IL-6 level was significantly higher in nonsurvivors compared with survivors. We found an association of genotype with the IL-6 level in nonsurvivors, but not in survivors. Our findings show a functional significance of IL-6 promoter polymorphisms in nonsurviving severe sepsis patients.

Association of TNF-α and Fas gene promoter polymorphism with the risk of Kashin–Beck disease in Northwest Chinese population

2012 ◽  
Vol 31 (7) ◽  
pp. 1051-1057 ◽  
Author(s):  
Quan-ming Zhao ◽  
Xiong Guo ◽  
Jiang-hua Lai ◽  
Wu-hong Tan ◽  
Wei-zhuo Wang ◽  
...  
Keyword(s):  
Chinese Population ◽  
Gene Promoter ◽  
Promoter Polymorphism ◽  
Tnf Α ◽  
Beck Disease ◽  
Gene Promoter Polymorphism
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