scholarly journals A randomized, placebo-controlled, single-blinded, split-faced clinical trial evaluating the efficacy and safety of KLOX-001 gel formulation with KLOX light-emitting diode light on facial rejuvenation

2016 ◽  
pp. 115 ◽  
Author(s):  
Stephane Fauverghe ◽  
Steven Bernstein ◽  
Brian Kinney ◽  
Nicolo Scuderi ◽  
Shipra Rastogi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Light Emitting Diode ◽  
Facial Rejuvenation ◽  
Efficacy And Safety ◽  
Light Emitting

scholarly journals Impact of Molar Furcations on Photodynamic Therapy Outcomes: A 6-Month Split-Mouth Randomized Clinical Trial

2020 ◽  
Vol 17 (11) ◽  
pp. 4162
Author(s):  
Aymeric Courval ◽  
Laetitia Harmouche ◽  
Anne Mathieu ◽  
Catherine Petit ◽  
Olivier Huck ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Light Emitting Diode ◽  
Periodontal Therapy ◽  
Therapy Outcomes ◽  
Photodynamic Treatment ◽  
Light Emitting ◽  
Probing Depth ◽  
Furcation Involvement ◽  
The Impact

The effectiveness of adjunctive photodynamic treatment (PDT) to non-surgical periodontal therapy has been shown to depend on initial periodontal status. As molar furcation involvement impairs healing response to non-surgical periodontal therapy, the aim of this study was to evaluate the impact of furcation involvement on PDT outcomes. Thirty-six patients suffering from severe chronic periodontitis were included in a 6-month split-mouth randomized clinical trial. PDT applications used the toluidine blue O and a light-emitting diode (LED) with a red spectrum. Repeated PDT applications were performed in addition to non-surgical periodontal treatment at baseline and at 3-months. Pocket probing depth (PPD), plaque index, bleeding on probing, and clinical attachment level were recorded at baseline, and again at 3- and 6-months. Furcation sites of molars were compared to other sites of molars and non-molars. Multilevel analysis showed no PDT effect in molar furcation sites while an additional significant reduction (odds ratio = 0.67) of pockets with PPD > 5 mm in other sites at 3-months was measured. PPD reduction appeared delayed in molar furcation sites treated with PDT. There is no additional apparent benefit to use PDT in molar furcation sites for the reduction of pockets with PPD > 5 mm contrary to other sites.

scholarly journals Effect of Light-Emitting Diode Phototherapy on Allograft Bone After Open Sinus Lift Surgery: A Randomized Clinical Trial (Concurrent Parallel)

2021 ◽  
Vol 12 (1) ◽  
pp. e16-e16
Author(s):  
Mahnaz Arshad ◽  
Zahra Ghanavati ◽  
Pouyan Aminishakib ◽  
Kamran Rasouli ◽  
Gholamreza Shirani
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Light Emitting Diode ◽  
Low Level Laser Therapy ◽  
Control Group ◽  
Sinus Lift ◽  
Light Emitting ◽  
Led Phototherapy ◽  
Significant Difference ◽  
History Of

Introduction: Phototherapy with a light-emitting diode (LED) is used in medicine due to its potential bio-stimulatory effects on the human body. However, controversy still exists regarding the efficacy of low-level laser therapy (LLLT) and phototherapy with LED. This in vivo study aimed to quantitatively and qualitatively assess the newly formed bone following LED phototherapy of the human maxillary sinuses. Methods: This randomized clinical trial (concurrent parallel) was conducted on 44 patients in two groups (n=22) at the Implant Department of Tehran University of Medical Sciences. Randomization was done by a random sequence generator program. The inclusion criteria were absence of chronic sinusitis and chronic bone marrow conditions, no history of surgery at the site, absence of diabetes mellitus, no history of chemotherapy or radiotherapy, maxillary premolar edentulism, and signing informed consent forms. Group A underwent LED phototherapy with 620 ± 2 nm wavelength for 20 minutes daily for a total of 21 days after sinus lift surgery. Group B served as the control group and did not receive phototherapy. After 6 months, the grafted sites were re-opened for implant placement, and bone biopsy samples were obtained using a trephine bur. The samples were stained with hematoxylin and eosin and inspected under a light microscope. The results were statistically analyzed using the Mann-Whitney U test. Both the surgeon and pathologist were blinded to the group allocation of patients. Results: Forty tissue specimens were analyzed. Insignificant differences existed between the two groups in terms of the degree of inflammation, bone quality, and maturity of collagen. Histological analyses revealed no significant difference in the mineralized areas of bone between the two groups (P>0.05). Conclusion: The results indicated that LED phototherapy cannot significantly enhance osteogenesis after sinus lift surgery. No side effects were observed in the experimental group.

Sign in / Sign up

Export Citation Format

Share Document