scholarly journals Rationale for targeted therapies and potential role of pazopanib in advanced renal cell carcinoma

2010 ◽  
pp. 187
Author(s):  
Peter Clark
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Targeted Therapies ◽  
Renal Cell ◽  
Potential Role ◽  
Advanced Renal Cell Carcinoma

Targeted therapies in advanced renal cell carcinoma: the role of metastatic sites as a prognostic factor

2014 ◽  
Vol 10 (8) ◽  
pp. 1361-1372 ◽  
Author(s):  
Paolo Grassi ◽  
Elena Verzoni ◽  
Luca Porcu ◽  
Isabella Testa ◽  
Roberto Iacovelli ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Targeted Therapies ◽  
Renal Cell ◽  
Advanced Renal Cell Carcinoma ◽  
Metastatic Sites

Recent advances in the treatment of renal cell carcinoma and the role of targeted therapies

2008 ◽  
Vol 44 (15) ◽  
pp. 2152-2161 ◽  
Author(s):  
Simon Chowdhury ◽  
James M.G. Larkin ◽  
Martin E. Gore
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Targeted Therapies ◽  
Renal Cell ◽  
Recent Advances

scholarly journals Survival Among Advanced Renal Cell Carcinoma (ARCC) Patients with >2 Prior Targeted Therapies

2012 ◽  
Vol 23 ◽  
pp. ix272
Author(s):  
E. Calvo ◽  
R. Casciano ◽  
L. Stern ◽  
T. Brechenmacher ◽  
S. Stergiopoulos ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Targeted Therapies ◽  
Renal Cell ◽  
Advanced Renal Cell Carcinoma

scholarly journals Effect of perineoplasm perinephric adipose tissues on migration of clear cell renal cell carcinoma cells: a potential role of WNT signaling

Oncotarget ◽  
2016 ◽  
Vol 7 (33) ◽  
pp. 53277-53288 ◽  
Author(s):  
Xiaolin Zi ◽  
Achim Lusch ◽  
Christopher A. Blair ◽  
Zhamshid Okhunov ◽  
Noriko N. Yokoyama ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Wnt Signaling ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Potential Role ◽  
Clear Cell ◽  
Carcinoma Cells ◽  
Cell Renal Cell Carcinoma ◽  
Adipose Tissues

scholarly journals Current Landscape and the Potential Role of Hypoxia-Inducible Factors and Selenium in Clear Cell Renal Cell Carcinoma Treatment

2018 ◽  
Vol 19 (12) ◽  
pp. 3834 ◽  
Author(s):  
Rohan Garje ◽  
Josiah An ◽  
Kevin Sanchez ◽  
Austin Greco ◽  
Jeffrey Stolwijk ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Drug Resistance ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Potential Role ◽  
Clear Cell ◽  
Hypoxia Inducible Factors ◽  
Angiogenic Growth Factors ◽  
Cell Renal Cell Carcinoma

In the last two decades, the discovery of various pathways involved in renal cell carcinoma (RCC) has led to the development of biologically-driven targeted therapies. Hypoxia-inducible factors (HIFs), angiogenic growth factors, von Hippel–Lindau (VHL) gene mutations, and oncogenic microRNAs (miRNAs) play essential roles in the pathogenesis and drug resistance of clear cell renal cell carcinoma. These insights have led to the development of vascular endothelial growth factor (VEGF) inhibitors, Mechanistic target of rapamycin (mTOR) inhibitors, and immunotherapeutic agents, which have significantly improved the outcomes of patients with advanced RCC. HIF inhibitors will be a valuable asset in the growing therapeutic armamentarium of RCC. Various histone deacetylase (HDAC) inhibitors, selenium, and agents like PT2385 and PT2977 are being explored in various clinical trials as potential HIF inhibitors, to ameliorate the outcomes of RCC patients. In this article, we will review the current treatment options and highlight the potential role of selenium in the modulation of drug resistance biomarkers expressed in clear cell RCC (ccRCC) tumors.

scholarly journals Use of targeted therapies for advanced renal cell carcinoma in the Veterans Health Administration

2019 ◽  
Vol 8 (15) ◽  
pp. 6651-6661 ◽  
Author(s):  
Sherrie L. Aspinall ◽  
Xinhua Zhao ◽  
Mark C. Geraci ◽  
Chester B. Good ◽  
Francesca E. Cunningham ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Targeted Therapies ◽  
Renal Cell ◽  
Veterans Health Administration ◽  
Advanced Renal Cell Carcinoma ◽  
Veterans Health ◽  
Health Administration
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