scholarly journals Detection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent

2010 ◽  
pp. 199 ◽  
Author(s):  
Peter Reimer
Keyword(s):  
Contrast Agent ◽  
Gadoxetic Acid ◽  
Liver Lesions ◽  
Tissue Specific

scholarly journals The possibility of applying magnetic resonance imaging with hepatospecific contrast agent.

2018 ◽  
Vol 96 (3) ◽  
pp. 213-221
Author(s):  
Karina K. Lomovtseva ◽  
G. G. Karmazanovsky
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Gadoxetic Acid ◽  
Focal Liver Lesions ◽  
Hepatobiliary Phase ◽  
Liver Lesions ◽  
Resonance Imaging ◽  
Cross Sectional ◽  
Extracellular Contrast Agent

Nowadays, it is difficult to overestimate the role of cross-sectional imaging in the diagnosis of focal and diffuse liver diseases. In magnetic resonance imaging (MRI) there is a unique opportunity to use hepatospecific contrast agents compared with other visualization techniques. Gadoxetic acid is a hepatospecific magnetic resonance contrast agent which has the extracellular contrast agent properties and hepatotropic property. About half of the administered dose of gadoxetic acid enters into functioning hepatocytes through cell membrane transporters and then is excreted into the bile ducts and sinusoidal space. The obtained hepatobiliary phase provides information about the structural features of the focal liver lesions, improving their detection and differential diagnosis. In addition it allows to assess the anatomical and functional conditions of the hepatobiliary system. This article describes clinical applications of MRI with gadoxetic acid and its benefits, visualization principles of different focal liver lesions in hepatobiliary phase and features of the obtained images.

Characterization of Focal Liver Lesions in Real Time Using Harmonic Imaging with High Mechanical Index and Contrast Agent Levovist

2004 ◽  
Vol 182 (6) ◽  
pp. 1505-1512 ◽  
Author(s):  
V. Migaleddu ◽  
G. Virgilio ◽  
D. Turilli ◽  
M. Conti ◽  
G. Campisi ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Real Time ◽  
Harmonic Imaging ◽  
Focal Liver Lesions ◽  
Mechanical Index ◽  
Liver Lesions

Detection, classification, and characterization of focal liver lesions: Value of diffusion-weighted MR imaging, gadoxetic acid-enhanced MR imaging and the combination of both methods

2011 ◽  
Vol 37 (1) ◽  
pp. 74-82 ◽  
Author(s):  
Konstantin Holzapfel ◽  
Matthias J. Eiber ◽  
Alexander A. Fingerle ◽  
Melanie Bruegel ◽  
Ernst J. Rummeny ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Gadoxetic Acid ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Diffusion Weighted

Characterization of Focal Liver Lesions with Pulse Inversion Harmonic Imaging (PIHI) Using a Second Generation US Contrast Agent

2002 ◽  
Vol 9 (2) ◽  
pp. S376-S379 ◽  
Author(s):  
Emilio Quaia ◽  
Fulvio Stacul ◽  
Michele Bertolotto ◽  
Martina Locatelli ◽  
Roberto Pozzi Mucelli
Keyword(s):  
Contrast Agent ◽  
Second Generation ◽  
Harmonic Imaging ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Pulse Inversion ◽  
Pulse Inversion Harmonic Imaging

CHARACTERIZATION OF CANINE FOCAL LIVER LESIONS WITH CONTRAST-ENHANCED ULTRASOUND USING A NOVEL CONTRAST AGENT-SONAZOID

2009 ◽  
Vol 50 (2) ◽  
pp. 188-194 ◽  
Author(s):  
HIDEYUKI KANEMOTO ◽  
KOICHI OHNO ◽  
KO NAKASHIMA ◽  
MASASHI TAKAHASHI ◽  
YASUHITO FUJINO ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

scholarly journals MRI characterization of focal liver lesions in non-cirrhotic patients: assessment of added value of gadoxetic acid-enhanced hepatobiliary phase imaging

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Bardia Moosavi ◽  
Anuradha S. Shenoy-Bhangle ◽  
Leo L. Tsai ◽  
Robert Reuf ◽  
Koenraad J. Mortele
Keyword(s):  
Gadoxetic Acid ◽  
Added Value ◽  
Rank Test ◽  
Focal Liver Lesions ◽  
Hepatobiliary Phase ◽  
Liver Lesions ◽  
Enhanced Mri ◽  
Phase Images ◽  
Cirrhotic Patients

Abstract Background To evaluate the added value of the hepatobiliary (HPB) phase in gadoxetic acid-enhanced magnetic resonance imaging (MRI) in characterizing newly discovered indeterminate focal liver lesions in non-cirrhotic patients. Results One-hundred and twenty-five non-cirrhotic patients (median age, 46 years; range, 20–85 years; 100 females) underwent gadoxetic acid-enhanced MRI, including the 20-min delayed HPB phase, for characterization of newly discovered focal liver lesions. Images were independently evaluated by two blinded, board-certified abdominal radiologists (R1 and R2) who characterized liver lesions without and with assessment of the HPB phase images in two separate readout sessions. Confidence in diagnosis was scored on a scale from 0 to 3. Inter-observer agreement was assessed using Cohen κ statistics. Change in diagnosis and confidence in diagnosis were evaluated by Wilcoxon signed rank test. There was no significant change in diagnosis before and after evaluation of the HPB phase for both readers (p = 1.0 for R1; p = 0.34 for R2). Confidence in diagnosis decreased from average 2.8 ± 0.45 to 2.6 ± 0.59 for R1 and increased from 2.6 ± 0.83 to 2.8 ± 0.46 for R2. Change in confidence was only statistically significant for R1 (p = 0.003) but not significant for R2 (p = 0.49). Inter-reader agreement in diagnosis was good without (k = 0.66) and with (k = 0.75) inclusion of the HPB phase images. Conclusions The added information obtained from the HPB phase of gadoxetic acid-enhanced MRI does not change the diagnosis or increase confidence in diagnosis when evaluating new indeterminate focal liver lesions in non-cirrhotic patients.

scholarly journals The role of gadoxetic acid as a paramagnetic contrast medium in the characterization and detection of focal liver lesions: a review

2015 ◽  
Vol 48 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Renata Lilian Bormann ◽  
Eduardo Lima da Rocha ◽  
Marcelo Longo Kierzenbaum ◽  
Bruno Cheregati Pedrassa ◽  
Lucas Rios Torres ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Magnetic Resonance Images ◽  
Gadoxetic Acid ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Agent Based ◽  
Contrast Enhanced ◽  
Hepatobiliary Contrast Agents

Recent studies have demonstrated that the use of paramagnetic hepatobiliary contrast agents in the acquisition of magnetic resonance images remarkably improves the detection and differentiation of focal liver lesions, as compared with extracellular contrast agents. Paramagnetic hepatobiliary contrast agents initially show the perfusion of the lesions, as do extracellular agents, but delayed contrast-enhanced images can demonstrate contrast uptake by functional hepatocytes, providing further information for a better characterization of the lesions. Additionally, this intrinsic characteristic increases the accuracy in the detection of hepatocellular carcinomas and metastases, particularly the small-sized ones. Recently, a hepatobiliary contrast agent called gadolinium ethoxybenzyl dimeglumine, that is simply known as gadoxetic acid, was approved by the National Health Surveillance Agency for use in humans. The authors present a literature review and a practical approach of magnetic resonance imaging utilizing gadoxetic acid as contrast agent, based on patients' images acquired during their initial experiment.

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