scholarly journals State-of-the-Art of Monoclonal Antibodies for the Treatment of Gastric Cancer

2021 ◽  
Vol Volume 15 ◽  
pp. 451-462
Author(s):  
Debora Basile ◽  
Francesca Simionato ◽  
Alessandro Cappetta ◽  
Silvio Ken Garattini ◽  
Giandomenico Roviello ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Monoclonal Antibodies ◽  
State Of The Art

State of the art treatment for gastric cancer: future directions

2004 ◽  
Vol 2 (7) ◽  
pp. 40-47 ◽  
Author(s):  
A. Cervantes ◽  
V. Georgoulias ◽  
A. Falcone
Keyword(s):  
Gastric Cancer ◽  
State Of The Art ◽  
Future Directions

scholarly journals Human(ized) monoclonal antibodies in atopic patients – state of the art

2020 ◽  
Vol 45 (2) ◽  
pp. 195-201
Author(s):  
Arzu Didem Yalcin ◽  
Kevser Onbasi ◽  
Rusen Uzun ◽  
Felix Herth ◽  
Philipp Albert Schnabel
Keyword(s):  
Monoclonal Antibodies ◽  
State Of The Art

Surgery for Gastric Cancer: State of the Art

2020 ◽  
Author(s):  
Manish S. Bhandare ◽  
Vikram Chaudhari ◽  
Shailesh V. Shrikhande
Keyword(s):  
Gastric Cancer ◽  
State Of The Art

scholarly journals A gastric cancer LncRNAs model for MSI and survival prediction based on support vector machine

BMC Genomics ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Tao Chen ◽  
Cangui Zhang ◽  
Yingqiao Liu ◽  
Yuyun Zhao ◽  
Dingyi Lin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Support Vector Machine ◽  
Overall Survival ◽  
Transcriptional Regulation ◽  
Monoclonal Antibodies ◽  
Tumor Therapy ◽  
Disease Free Survival ◽  
Stage I ◽  
Support Vector ◽  
Survival Prediction

Abstract Background Recent studies have shown that long non-coding RNAs (lncRNAs) play a crucial role in the induction of cancer through epigenetic regulation, transcriptional regulation, post-transcriptional regulation and other aspects, thus participating in various biological processes such as cell proliferation, differentiation and apoptosis. As a new nova of anti-tumor therapy, immunotherapy has been shown to be effective in many tumors of which PD-1/PD-L1 monoclonal antibodies has been proofed to increase overall survival rate in advanced gastric cancer (GC). Microsatellite instability (MSI) was known as a biomarker of response to PD-1/PD-L1 monoclonal antibodies therapy. The aim of this study was to identify lncRNAs signatures able to classify MSI status and create a predictive model associated with MSI for GC patients. Methods Using the data of Stomach adenocarcinoma from The Cancer Genome Atlas (TCGA), we developed and validated a lncRNAs model for automatic MSI classification using a machine learning technology – support vector machine (SVM). The C-index was adopted to evaluate its accuracy. The prognostic values of overall survival (OS) and disease-free survival (DFS) were also assessed in this model. Results Using the SVM, a lncRNAs model was established consisting of 16 lncRNA features. In the training cohort with 94 GC patients, accuracy was confirmed with AUC 0.976 (95% CI, 0.952 to 0.999). Veracity was also confirmed in the validation cohort (40 GC patients) with AUC 0.950 (0.889 to 0.999). High predicted score was correlated with better DFS in the patients with stage I-III and lower OS with stage I-IV. Conclusion This study identify 16 LncRNAs signatures able to classify MSI status. The correlation between lncRNAs and MSI status indicates the potential roles of lncRNAs interacting in immunotherapy for GC patients. The pathway of these lncRNAs which might be a target in PD-1/PD-L1 immunotherapy are needed to be further study.

scholarly journals State of the art in the treatment of gastric cancer: from the 71st Japanese Gastric Cancer Congress

1999 ◽  
Vol 2 (3) ◽  
pp. 151-157 ◽  
Author(s):  
Masashi Fujii ◽  
Juei Sasaki ◽  
Toshifusa Nakajima
Keyword(s):  
Gastric Cancer ◽  
State Of The Art

HUMAN GASTRIC CANCER-ASSOCIATED ANTIGENS AND CARCINOEMBRYONIC ANTIGEN DETECTED BY MONOCLONAL ANTIBODIES

1983 ◽  
Vol 417 (1 Oncodevelopme) ◽  
pp. 158-168 ◽  
Author(s):  
Akira Yachi ◽  
Kohzoh Imai ◽  
Yasuo Moriya ◽  
Hideo Fujita ◽  
Mariko Tanda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Monoclonal Antibodies ◽  
Carcinoembryonic Antigen ◽  
Human Gastric Cancer

Development of Novel Monoclonal Antibodies for Evaluation of Transmembrane Prostate Androgen-Induced Protein 1 (TMEPAI) Expression Patterns in Gastric Cancer

2017 ◽  
Vol 24 (2) ◽  
pp. 427-438 ◽  
Author(s):  
Mikhail S. Karbyshev ◽  
Evgeniya S. Grigoryeva ◽  
Viktor V. Volkomorov ◽  
Elisabeth Kremmer ◽  
Alexander Huber ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Monoclonal Antibodies ◽  
Expression Patterns

scholarly journals Designer monoclonal antibodies as drugs: the state of the art

2008 ◽  
Vol 4 (3) ◽  
pp. 305-307 ◽  
Author(s):  
Shyam Mohapatra ◽  
Homero San Juan
Keyword(s):  
Monoclonal Antibodies ◽  
State Of The Art ◽  
The State
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