scholarly journals Drug-Resistant Breast Cancer: Dwelling the Hippo Pathway to Manage the Treatment

2021 ◽  
Vol Volume 13 ◽  
pp. 691-700
Author(s):  
Simran Kaur ◽  
Mohammad Zeeshan Najm ◽  
Mohammad Aasif Khan ◽  
Naseem Akhter ◽  
Vyas M Shingatgeri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hippo Pathway ◽  
Drug Resistant ◽  
The Hippo Pathway

scholarly journals Targeting the Hippo Pathway for Breast Cancer Therapy

Cancers ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 422 ◽  
Author(s):  
Liqing Wu ◽  
Xiaolong Yang
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Targeted Therapies ◽  
Hippo Pathway ◽  
Targeted Drugs ◽  
Breast Cancer Therapy ◽  
The World ◽  
Core Components ◽  
Future Direction ◽  
The Hippo Pathway

Breast cancer (BC) is one of the most prominent diseases in the world, and the treatments for BC have many limitations, such as resistance and a lack of reliable biomarkers. Currently the Hippo pathway is emerging as a tumor suppressor pathway with its four core components that regulate downstream transcriptional targets. In this review, we introduce the present targeted therapies of BC, and then discuss the roles of the Hippo pathway in BC. Finally, we summarize the evidence of the small molecule inhibitors that target the Hippo pathway, and then discuss the possibilities and future direction of the Hippo-targeted drugs for BC therapy.

Zinc finger protein 367 promotes metastasis by inhibiting the Hippo pathway in breast cancer

Oncogene ◽  
2020 ◽  
Vol 39 (12) ◽  
pp. 2568-2582 ◽  
Author(s):  
Xianqiu Wu ◽  
Xin Zhang ◽  
Liang Yu ◽  
Chen Zhang ◽  
Liping Ye ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Hippo Pathway ◽  
Finger Protein ◽  
The Hippo Pathway

scholarly journals α-Arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis

2021 ◽  
Vol 134 (8) ◽  
Author(s):  
Aleena K. S. Arakaki ◽  
Wen-An Pan ◽  
Helen Wedegaertner ◽  
Ivette Roca-Mercado ◽  
Logan Chinn ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Cancer Progression ◽  
Cancer Metastasis ◽  
Hippo Pathway ◽  
Breast Cancer Metastasis ◽  
Migration And Invasion ◽  
Hippo Signaling ◽  
The Hippo Pathway

ABSTRACT The α-arrestin domain containing protein 3 (ARRDC3) is a tumor suppressor in triple-negative breast carcinoma (TNBC), a highly metastatic subtype of breast cancer that lacks targeted therapies. Thus, understanding the mechanisms and targets of ARRDC3 in TNBC is important. ARRDC3 regulates trafficking of protease-activated receptor 1 (PAR1, also known as F2R), a G-protein-coupled receptor (GPCR) implicated in breast cancer metastasis. Loss of ARRDC3 causes overexpression of PAR1 and aberrant signaling. Moreover, dysregulation of GPCR-induced Hippo signaling is associated with breast cancer progression. However, the mechanisms responsible for Hippo dysregulation remain unknown. Here, we report that the Hippo pathway transcriptional co-activator TAZ (also known as WWTR1) is the major effector of GPCR signaling and is required for TNBC migration and invasion. Additionally, ARRDC3 suppresses PAR1-induced Hippo signaling via sequestration of TAZ, which occurs independently of ARRDC3-regulated PAR1 trafficking. The ARRDC3 C-terminal PPXY motifs and TAZ WW domain are crucial for this interaction and are required for suppression of TNBC migration and lung metastasis in vivo. These studies are the first to demonstrate a role for ARRDC3 in regulating GPCR-induced TAZ activity in TNBC and reveal multi-faceted tumor suppressor functions of ARRDC3. This article has an associated First Person interview with the first author of the paper.

scholarly journals High Nuclear Expression of Yes-Associated Protein 1 (YAP1) Correlates with Metastasis in Patients with Breast Cancer

2020 ◽  
Author(s):  
Yoon Jin Cha ◽  
Soong June Bae ◽  
Dooreh Kim ◽  
Sung Gwe Ahn ◽  
Joon Jeong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hippo Pathway ◽  
External Validation ◽  
Free Survival ◽  
Severance Hospital ◽  
Aggressive Tumor ◽  
The Hippo Pathway ◽  
The Impact ◽  
Different Levels

Abstract Background: Yes-associated protein 1 (YAP1) is a transcription factor regulated by the Hippo pathway and functions as an oncogene in various solid tumors under dysregulated Hippo pathway. However, the role of YAP1 in breast cancer is controversial. Here, we investigated the impact of different levels of nuclear YAP1 expression on the clinical characteristics and survival outcome of patients with breast cancer.Patients and Methods: Retrospectively obtained 469 breast tumor samples at the Gangnam Severance Hospital were examined for YAP1 expression by immunohistochemistry, and the clinical data were analyzed. External validation was performed using a retrospective cohort and tissues in 489 patients from Severance Hospital.Results: High nuclear YAP1 expression was associated with hormone receptor negativity and aggressive tumor behavior, including lymph node metastasis, high Ki67 labeling index and inferior distant metastasis-free survival (DMFS), and also confirmed in external validation cohort. In patients with triple-negative breast cancer (TNBC), high nuclear YAP1 expression was an independent significant determinant of poor DMFS (HR 1.947, 95% CIs 1.003-3.779, P=0.049).Conclusion: Our findings suggest that nuclear YAP1 expression is a biomarker of adverse prognosis and a potential therapeutic target in patients with breast cancer, especially in TNBC.

scholarly journals Genetic variation in the Hippo pathway and breast cancer risk in women of African ancestry

2018 ◽  
Vol 57 (10) ◽  
pp. 1311-1318 ◽  
Author(s):  
Shengfeng Wang ◽  
Dezheng Huo ◽  
Temidayo O. Ogundiran ◽  
Oladosu Ojengbede ◽  
Wei Zheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Variation ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
African Ancestry ◽  
Hippo Pathway ◽  
The Hippo Pathway

Abstract PR01: Loss of the hippo pathway scaffold “Kibra” in a mouse model of human claudin-low breast cancer

2013 ◽  
Author(s):  
Jennifer F. Knight ◽  
Robert Lesurf ◽  
Sadiq M. Saleh ◽  
Ryan R. Davis ◽  
Hong Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Hippo Pathway ◽  
The Hippo Pathway
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