scholarly journals Antiproliferation Activity and Apoptotic Mechanism of Soursop (Annona muricata L.) Leaves Extract and Fractions on MCF7 Breast Cancer Cells

2021 ◽  
Vol Volume 13 ◽  
pp. 447-457
Author(s):  
Yuni Elsa Hadisaputri ◽  
Ummi Habibah ◽  
Fajar Fauzi Abdullah ◽  
Eli Halimah ◽  
Mutakin Mutakin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Annona Muricata ◽  
Apoptotic Mechanism

scholarly journals Effects of Annona muricata Extract on Triple-Negative Breast Cancer Cells Mediated Through EGFR Signaling

2020 ◽  
Vol Volume 12 ◽  
pp. 12519-12526
Author(s):  
Heba K Alshaeri ◽  
Moudi Alasmari ◽  
Zuhair Natto ◽  
Alejandro Pino-Figueroa
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Annona Muricata ◽  
Egfr Signaling

scholarly journals Purified essential oil from Ocimum sanctum Linn. triggers the apoptotic mechanism in human breast cancer cells

2016 ◽  
Vol 12 (46) ◽  
pp. 327 ◽  
Author(s):  
Ramaraj Thirugnanasampandan ◽  
Thamilvaani Manaharan ◽  
Rajarajeswaran Jayakumar ◽  
MS Kanthimathi ◽  
Gunasekar Ramya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Essential Oil ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Ocimum Sanctum ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Apoptotic Mechanism

scholarly journals Curcumin as an Anti-Proliferative Agent in Breast Cancer through RASSF1A, Bax, and Caspase-3 Protein

2021 ◽  
Vol 2 (1) ◽  
pp. 19-27
Author(s):  
Nunung Ainur Rahma ◽  
Harliansyah ◽  
Fransiscus D. Suyatna ◽  
Mpu Kanoko ◽  
Primariadewi Rustamadji ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Caspase 3 ◽  
Cell Types ◽  
Specific Mechanism ◽  
Protein Levels ◽  
Bax Protein ◽  
The Relationship ◽  
Apoptotic Mechanism

Introduction: Curcumin is a polyphenol that has pharmacological activity that can inhibit tumor cell growth and induce apoptosis through various mechanisms. However, the specific mechanism of curcumin cytotoxicity remains controversial because of many anti- and pro-apoptotic signaling pathways in various cell types. This study aims to examine the relationship among curcumin on RASSF1A, Bax protein levels, and caspase-3 activity in supporting the apoptotic mechanism in CSA03 breast cancer cells. Method: Curcumin administration to cancer cells is based on differences in dosage with 24-hour incubation. Cytotoxicity after curcumin administration was determined using MTS. RASSF1A and Bax protein levels were tested through ELISA. Caspase-3 activity was used to determine apoptosis and was tested using flow cytometry. Results: The results indicated that curcumin had a cytotoxicity effect of 40.85 µg/mL. At concentrations of 40 µg/mL and 50 µg/mL, curcumin increases levels of protein RASSF1A (∆ = 26.53% and 47.35%, respectively), Bax (∆ = 48.79% and 386.15%), and caspase-3 (∆ = 1,678.51% and 1,871.889%) significantly. Conclusions: Curcumin exhibits anti-proliferative activity and apoptotic (Caspase-3) effects through activation of RASSF1A and Bax.

The proliferation of breast cancer cells are inhibited by the human intrabody targeting cyclinD1

2010 ◽  
Vol 34 (8) ◽  
pp. S49-S49
Author(s):  
Lei Wang ◽  
Xun Zhou ◽  
Lihong Zhou ◽  
Yong Chen ◽  
Xun Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells
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