Should estimates of glomerular filtration rate and creatinine clearance be indexed to body surface area for drug dosing?

2017 ◽  
Vol 74 (21) ◽  
pp. 1814-1819 ◽  
Author(s):  
David E. Nix ◽  
Michael Mayersohn ◽  
Brian L. Erstad
Keyword(s):  
Glomerular Filtration Rate ◽  
Creatinine Clearance ◽  
Glomerular Filtration ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Filtration Rate ◽  
Drug Dosing

Estimation of glomerular filtration rate by MDRD equation in athletes: role of body surface area

2011 ◽  
Vol 112 (1) ◽  
pp. 201-206 ◽  
Author(s):  
Radoje Milic ◽  
Alessandra Colombini ◽  
Giovanni Lombardi ◽  
Patrizia Lanteri ◽  
Giuseppe Banfi
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Filtration Rate ◽  
Mdrd Equation

Single-injection inulin clearance for routine measurement of glomerular filtration rate in cats

2003 ◽  
Vol 5 (3) ◽  
pp. 175-181 ◽  
Author(s):  
M Haller ◽  
K Rohner ◽  
W Müller ◽  
F Reutter ◽  
H Binder ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Filtration Rate ◽  
Normal Values ◽  
Single Injection ◽  
Inulin Clearance ◽  
Attractive Alternative

Glomerular filtration rate (GFR) was determined in 53 cats using an inulin single-injection method. Thirty healthy young adult cats were used to establish normal values. The procedure was also used in 23 cats that were either older than 10 years or had borderline serum creatinine levels. The total clearance was calculated from the decay of the serum inulin concentration after injection of 3000 mg/m2body surface area using a two-compartment model. Concomitant inulin and iohexol clearance in nine cats showed excellent correlation between the two methods. Calculated normal values for GFR in 30 healthy cats were 35.9–58.5 (median 46.0) ml/min/m2or 2.07–3.69 (median 2.72) ml/min/kg. A few cats with normal creatinine or blood urea nitrogen levels were detected as having reduced GFR and therefore being in a state of early renal dysfunction. The study indicates that single-injection inulin clearance is a valuable tool for routine GFR measurement in cats. An ‘inulin excretion test’ using only one blood sample 3 h after the administration of 3000 mg/m2body surface area could prove an attractive alternative for the assessment of renal function in daily practice.

Development and validation of a dosing nomogram for amoxicillin in infective endocarditis

2020 ◽  
Vol 75 (10) ◽  
pp. 2941-2950
Author(s):  
Antoine Rambaud ◽  
Benjamin Jean Gaborit ◽  
Colin Deschanvres ◽  
Paul Le Turnier ◽  
Raphaël Lecomte ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Plasma Concentration ◽  
Infective Endocarditis ◽  
Glomerular Filtration ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Filtration Rate ◽  
Population Pk ◽  
Dosing Nomogram

Abstract Background Amoxicillin is the first-line treatment for streptococcal or enterococcal infective endocarditis (IE) with a dose regimen adapted to weight. Objectives Covariates influencing pharmacokinetics (PK) of amoxicillin were identified in order to develop a dosing nomogram based on identified covariates for individual adaptation. Patients and methods Patients treated with amoxicillin administered by continuous infusion for IE were included retrospectively. The population PK analysis was performed using the Pmetrics package for R (NPAG algorithm). Influence of weight, ideal weight, height, BMI, body surface area, glomerular filtration rate adapted to the body surface area and calculated by the CKD-EPI method (mL/min), additional ceftriaxone treatment and serum protein level on amoxicillin PK was tested. A nomogram was then developed to determine the daily dose needed to achieve a steady-state free plasma concentration above 4× MIC, 100% of the time, without exceeding a total plasma concentration of 80 mg/L. Results A total of 160 patients were included. Population PK analysis was performed on 540 amoxicillin plasma concentrations. A two-compartment model best described amoxicillin PK and the glomerular filtration rate covariate significantly improved the model when included in the calculation of the elimination constant Ke. Conclusions This work allowed the development of a dosing nomogram that can help to increase achievement of the PK/pharmacodynamic targets in IE treated with amoxicillin.

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