Vasopressin-receptor antagonists in heart failure

2008 ◽  
Vol 65 (9) ◽  
pp. 807-817 ◽  
Author(s):  
Teresa A. Schweiger ◽  
Martin M. Zdanowicz
Keyword(s):  
Heart Failure ◽  
Vasopressin Receptor ◽  
Receptor Antagonists

scholarly journals Hyponatremia and Congestive Heart Failure: A Marker of Increased Mortality and a Target for Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Adam Romanovsky ◽  
Sean Bagshaw ◽  
Mitchell H. Rosner
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Free Water ◽  
Volume Overload ◽  
Decompensated Heart Failure ◽  
Vasopressin Receptor ◽  
Receptor Antagonists ◽  
Water Excretion ◽  
Multiple Systems ◽  
Developed World

Heart failure is one of the most common chronic medical conditions in the developed world. It is characterized by neurohormonal activation of multiple systems that can lead to clinical deterioration and significant morbidity and mortality. In this regard, hyponatremia is due to inappropriate and continued vasopressin activity despite hypoosmolality and volume overload. Hyponatremia is also due to diuretic use in an attempt to manage volume overload. When hyponatremia occurs, it is a marker of heart failure severity and identifies patients with increased mortality. The recent introduction of specific vasopressin-receptor antagonists offers a targeted pharmacological approach to these pathophysiological derangements. Thus far, clinical trials with vasopressin-receptor antagonists have demonstrated an increase in free-water excretion, improvement in serum sodium, modest improvements in dyspnea but no improvement in mortality. Continued clinical trials with these agents are needed to determine their specific role in the treatment of both chronic and decompensated heart failure.

Vasopressin receptor antagonists in the management of acute heart failure

2005 ◽  
Vol 14 (5) ◽  
pp. 593-600 ◽  
Author(s):  
WH Wilson Tang ◽  
Sanjeev Bhavnani ◽  
Gary S Francis
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Vasopressin Receptor ◽  
Receptor Antagonists

Vasopressin receptor antagonists in patients with chronic heart failure

Herz ◽  
2016 ◽  
Vol 42 (5) ◽  
pp. 492-497 ◽  
Author(s):  
R. De Vecchis ◽  
C. Cantatrione ◽  
D. Mazzei
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Vasopressin Receptor ◽  
Receptor Antagonists
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