Elevated serum transaminase levels resulting from concomitant use of rosuvastatin and amiodarone

2007 ◽  
Vol 64 (17) ◽  
pp. 1818-1821 ◽  
Author(s):  
Tonja Merz ◽  
Stephen H. Fuller
1986 ◽  
Vol 155 (2) ◽  
pp. 390-392 ◽  
Author(s):  
Frederik K. Lotgering ◽  
Jan Lind ◽  
Frans J.M. Huikeshoven ◽  
Henk C.S. Wallenburg

PEDIATRICS ◽  
1990 ◽  
Vol 86 (1) ◽  
pp. 87-90
Author(s):  
Halim M. Hennes ◽  
Douglas S. Smith ◽  
Kathleen Schneider ◽  
Mary A. Hegenbarth ◽  
Michael A. Duma ◽  
...  

The medical records of 43 hemodynamically stable children with elevated serum transaminase levels (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) who underwent abdominal computed tomographic (CT) scan for blunt abdominal trauma were reviewed. Nineteen patients (44.2%) had AST levels >450 IU/L and ALT levels >250 IU/L, and 17 of these 19 patients had hepatic injury identified on abdominal CT scan. Of the 43 patients, 25 (58.1%) had AST and ALT levels of less than 450 IU/L and 250 IU/L, respectively, and none of these patients had evidence of hepatic injury on CT scan. Elevated serum transaminase levels (AST >450 IU/L and ALT >250 IU/L) identified all of the patients with hepatic injury visible on abdominal CT scan. The sensitivity and specificity of elevated serum transaminase levels were 100% and 92.3%, respectively, for predicting hepatic injury. It is recommended that hemodynamically stable pediatric patients with blunt abdominal trauma and AST levels >450 IU/L and/or ALT levels >250 IU/L undergo abdominal CT scan to determine the presence and extent of hepatic injury. Children with serum transaminase levels below these values are at decreased risk of liver injury.


1969 ◽  
Vol 14 (10) ◽  
pp. 348-351
Author(s):  
Fashid Namdaran ◽  
M. A. Turner

Elevated serum transaminase levels after surgery may confirm the clinical and electrocardiographic (ECG) diagnosis of myocardial infarction. This useful aid to accurate diagnosis is even more important if the cardiac muscle has been the focal point of the operation when the ECG changes may not be as reliable as in other post-operative surgical cases. Similarly in the clinical evaluation the pain of myocardial origin may be confused with wound pain. If the serum transaminase does not rise more than 50 units per ml. after closed cardiac surgery, it may be considered that myocardial infarction has not occurred and that low cardiac output or severe chest pain probably has another cause. In this clinical investigation no significant difference was found between the post-operative serum transaminase levels of closed mitral valvotomy and a control thoracotomy series.


1961 ◽  
Vol 41 (1) ◽  
pp. 9-15 ◽  
Author(s):  
James W. Mosley ◽  
H. Bruce Dull ◽  
Theodore C. Doege ◽  
Harold D. Kuykendall

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