Stability of anhydrous theophylline in extemporaneously prepared alcohol-free oral suspensions

2005 ◽  
Vol 62 (23) ◽  
pp. 2518-2520 ◽  
Author(s):  
Cary E. Johnson ◽  
Shawna VanDekoppel ◽  
Erin Myers
Keyword(s):  
Anhydrous Theophylline

Dissolution of Theophylline Monohydrate and Anhydrous Theophylline in Buffer Solutions

1986 ◽  
Vol 75 (5) ◽  
pp. 497-501 ◽  
Author(s):  
Jan H. de Smidt ◽  
Jasper G. Fokkens ◽  
Hans Grijseels ◽  
Daan J.A. Crommelin
Keyword(s):  
Buffer Solutions ◽  
Theophylline Monohydrate ◽  
Anhydrous Theophylline

scholarly journals Polymorphs of anhydrous theophylline: stable form IV consists of dimer pairs and metastable form I consists of hydrogen-bonded chains

2011 ◽  
Vol 67 (12) ◽  
pp. o496-o499 ◽  
Author(s):  
Dikshitkumar Khamar ◽  
Robin Gavin Pritchard ◽  
Ian James Bradshaw ◽  
Gillian Ann Hutcheon ◽  
Linda Seton
Keyword(s):  
Stable Form ◽  
Metastable Form ◽  
Anhydrous Theophylline ◽  
Hydrogen Bonded

Bioavailability of a New Sustained-Release Anhydrous Theophylline Product

1996 ◽  
Vol 24 (4) ◽  
pp. 331-339 ◽  
Author(s):  
G Tatsis ◽  
G Tsoukalas ◽  
A Haviaras ◽  
A Peristerakis ◽  
V Filaditaki ◽  
...  
Keyword(s):  
Sustained Release ◽  
Adverse Reactions ◽  
Chronic Obstructive Lung Disease ◽  
New Product ◽  
Chronic Obstructive ◽  
Maximum Plasma ◽  
Theophylline Concentration ◽  
Time Curve ◽  
Plasma Theophylline ◽  
Anhydrous Theophylline

The bioavailability of a new sustained-release anhydrous theophylline product (Theophylline Lavipharm®) was evaluated and compared with the bioavailability of a well-established product, Theodur®. Two groups of 12 healthy non-smokers were given single doses of 200 or 300 mg of each product and two groups of 12 patients with asthma or chronic obstructive lung disease were given doses of 200 or 300 mg of each product every 12 h for 5-day periods. The values of the area under the plasma theophylline concentration against time curve (AUC), the maximum plasma theophylline concentration ( Cmax) and the time taken to reach Cmax (Tmax) for the two products did not differ significantly in the healthy groups or in the patients. The minimum and the average plasma theophylline concentrations and the fluctuation index were also calculated for the patients and there were no significant differences between the values for the two products. The new anhydrous theophylline product, Theophylline Lavipharm®, appears to show very similar bioavailability to Theodur®. No adverse reactions to the new product were reported.

scholarly journals Phase transition and heterogeneous/epitaxial nucleation of hydrated and anhydrous theophylline crystals

1992 ◽  
Vol 85 (1-3) ◽  
pp. 149-162 ◽  
Author(s):  
Naír Rodríguez-Hornedo ◽  
David Lechuga-Ballesteros ◽  
Hsiu-Jean Wu
Keyword(s):  
Phase Transition ◽  
Anhydrous Theophylline

scholarly journals In vitro study on the interaction of ketotifen fumarate with anhydrous theophylline

2012 ◽  
Vol 48 (2) ◽  
pp. 211-216
Author(s):  
Mohammed Aktar Sayeed ◽  
Razibul Habib ◽  
Mominur Rahman ◽  
Hasan Al Banna ◽  
Sohel Rana
Keyword(s):  
Stability Constants ◽  
Aqueous Media ◽  
In Vitro Study ◽  
Stable Complex ◽  
Concurrent Administration ◽  
Fixed Temperature ◽  
Ketotifen Fumarate ◽  
The Stability ◽  
Anhydrous Theophylline

The purpose of the present study was to investigate the interaction between ketotifen fumarate and anhydrous theophylline in aqueous media of various pH (1.2 and 6.8). Using Job's continuous-variation analysis and Ardon's spectrophotomeric measurement methods, the values of the stability constants of theophylline with ketotifen were determined at a fixed temperature (37 ºC) at various pH. The stability constants, ranging between 5.66 and 9.92, were derived from Ardon's plot, indicating that comparatively stable complexes had formed as a result of an interaction between the drugs. However, following the interaction of theophylline with ketotifen, stability constants were <1 at gastric pH (1.2) and intestinal pH (6.8). Concurrent administration of ketotifen and theophylline could result in the formation of a stable complex and this is likely to reduce the therapeutic activities of both drugs.

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