scholarly journals Higher adrenomedullin levels during implantation are associated with successful pregnancy

2020 ◽  
Vol 6 (2) ◽  
pp. FSO453
Author(s):  
Pervin Karli ◽  
Fatma D Bildircin ◽  
Ayse Z Ozdemir ◽  
Bahattin Avci
Keyword(s):  
Embryo Transfer ◽  
Human Embryo ◽  
Embryo Implantation ◽  
Frozen Embryo Transfer ◽  
Successful Pregnancy ◽  
Pregnancy Result ◽  
Day Of Embryo Transfer

Aim: To determine how the adrenomedullin (ADM) level in a woman’s serum on the day of embryo transfer affects pregnancy results.    Materials & Methods: Women who had undergone frozen embryo transfer between July 2018 and February 2019 were prospectively included in the study. The relation between the level of ADM and pregnancy result was examined after taking a sample of serum from each patients on the same day as the transfer. Results: The results revealed that the ADM levels in patients who became pregnant were higher, but not to a statistically significant level. Conclusion: Adrenomedullin is an important molecule for human embryo implantation.

Successful pregnancy following double-frozen embryo transfer in a patient with repeated implantation failure

2008 ◽  
Vol 90 (4) ◽  
pp. 1199.e13-1199.e15 ◽  
Author(s):  
Navid Esfandiari ◽  
Joan Coogan-Prewer ◽  
Lynda Gotlieb ◽  
E. Anne Claessens ◽  
Robert F. Casper
Keyword(s):  
Embryo Transfer ◽  
Frozen Embryo Transfer ◽  
Implantation Failure ◽  
Successful Pregnancy ◽  
Repeated Implantation Failure

scholarly journals Effects of pelvic floor bioelectrical stimulation on frozen embryo transfer patients with thin endometrium

2019 ◽  
Vol 17 ◽  
pp. 205873921882286
Author(s):  
Bing Yuan ◽  
Hong Zheng ◽  
Minling Xu ◽  
Xiaoli Mu ◽  
Fengcai Huang
Keyword(s):  
Pelvic Floor ◽  
Embryo Transfer ◽  
Embryo Implantation ◽  
Implantation Rate ◽  
Frozen Embryo Transfer ◽  
Control Group ◽  
Observation Group ◽  
Thin Endometrium ◽  
Significant Difference ◽  
Artificial Cycle

This study was to observe the effects of pelvic floor bioelectrical stimulation on pregnancy outcome and serum estradiol (E2) and progesterone (P) levels in frozen embryo transfer patients with thin endometrium. 120 cases frozen embryo transfer patients with thin endometrium in our hospital from March 2016 to April 2017 were selected. These patients received artificial cycle replacement plan before embryo transfer. According to whether pelvic floor bioelectrical stimulation therapy was accepted, 120 cases of thin endometrial frozen embryo transfer were divided into control group and observation group. 50 cases of the control group received artificial cycle to prepare for embryo transplantation, while 70 cases of observation group received bioelectrical stimulation as intervention treatment on the basis of artificial cycle. The intima thickness, subintimal hemodynamic parameters, embryo implantation rate, and clinical pregnancy rate were compared between the two groups before and after treatment. There was no significant difference in endometrial thickness between the two groups on the 10th day of menstruation ( P > 0.05). The thickness of endometrium and the index of intima growth in the observation group were significantly higher than those in the control group ( P < 0.05). The pulsatility index, resistance index, and systolic and diastolic blood flow velocity ratio of subintimal blood flow in the observation group were significantly higher than those in the control group ( P < 0.05). Before treatment, there was no significant difference in serum E2 and P between the two groups ( P > 0.05). After treatment, the improvement of serum E2 and P in the observation group was significantly better than that of the control group ( P < 0.05). The embryo implantation rate (25.7%) in the observation group was significantly higher than that in the control group (17.0%) ( P < 0.05). The clinical pregnancy rate (47.1%) in the observation group was significantly higher than that in the control group (30%) ( P < 0.05). In conclusion, the intervention of pelvic floor bioelectrical stimulation can improve the blood perfusion of thin endometrium, improve the endometrial receptivity, increase the implantation rate of frozen embryo transfer in patients with thin endometrium, and improve the level of serum estradiol and progesterone.

scholarly journals Endometrial thickness is a limiting factor in achieving a successful pregnancy in infertile women undergoing IVF/ICSI cycle.

2021 ◽  
Author(s):  
Haroon Latif Khan ◽  
Shahzad Bhatti ◽  
Samina ◽  
Humaira Hamayun ◽  
Farah Enver ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Embryo Transfer ◽  
Endometrial Thickness ◽  
Embryo Implantation ◽  
Implantation Rate ◽  
Cross Sectional Study ◽  
Limiting Factor ◽  
Successful Pregnancy ◽  
Cross Sectional ◽  
The Impact

Abstract Introduction: Embryo transfer into the uterus during IVF/ICSI treatment is followed by embryo implantation, which depends on the receptivity of endometrium and is a pre-requisite for the initiation of a successful pregnancy. The endometrium proliferates under the hormonal influence (estrogen and progesterone), which is reflected by its thickness which is measurable by transvaginal ultrasonic scanning (TVS). The thickness of the endometrium less than 8 mm has been linked with implantation failure.11 Endometrial thickness of 9-14 mm on the day of progesterone supplementation has been shown to have a higher implantation rate. Thus, the implantation potential of a good embryo remains low during IVF treatment despite ovarian stimulation methods of assisted fertilization and improved culture condition.Objectives: This study was planned to determine the impact of endometrial thickness on ET and pregnancy rate in Pakistani patients undergoing IVF/ ICSI.Methods: This was a prospective, cross-sectional study conducted at a private fertility clinic (Lahore institute of fertility and endocrinology, LIFE) in Lahore, Pakistan, from January 2015 to December 2015. In this study, all those cases were included that reached oocytes pickup and embryo transfer (ET). Two protocols, agonist and antagonist, were used. In all cases, human menopausal gonadotrophin (hMG) and follicle-stimulating hormone (FSH) were used for stimulation. Follicles development was monitored; at least 3 follicles were reached at the diameter of ≥16mm.Results: Thickness of endometrium on decision day was calculated at various ranges concerning both groups and find pregnancy rates. When endometrial thickness was ≤ 6mm, PR was 2.22%, 7mm pregnancy rate (PR) was 1.11%, 8 mm PR was 3.33%, 9mm PR was 17.78%, 10mm PR was 33.33%, 11mm PR was 32.22%, and more than 11 mm PR was 10%. So, PR was higher from 2.22% to 10%. The overall pregnancy rate was 45.45%.Conclusion: The study concluded that endometrial thickness has significant effects on embryo transfer and outcomes.

O-200 Frozen embryo transfer: Miscarriage rates depending on the starting day of intramuscular progesterone

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
N Kalhorpour ◽  
B Martin ◽  
O Kulski ◽  
J M Mayenga ◽  
I Grefenstette ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Embryo Transfer ◽  
Live Birth ◽  
Frozen Embryo Transfer ◽  
Ongoing Pregnancy ◽  
Miscarriage Rate ◽  
Ongoing Pregnancy Rate ◽  
Group A ◽  
Group B ◽  
Day Of Embryo Transfer

Abstract Study question Objective was to assess whether adjusting starting day of intramuscular progesterone the day of vaginal supplementation versus day of embryo transfer or later, might affect the outcome of the cycle. Summary answer additional injection of intramuscular progesterone the day of progesterone initiation or later, is not likely to be more effective on live birth and miscarriage rates. What is known already There is no consensus on the most effective method of endometrium preparation prior to FET. However, many studies report that high serum progesterone concentration during the implantation period is associated with optimal live birth rates. Adjusting progesterone treatment the day of embryo transfer seems to be too late and ineffective for rescuing low progesterone levels and should be done before. Study design, size, duration In this single center prospective study from October 2019 to november 2020, 239 patients undergoing hormonal replacement therapy protocol for frozen embryo transfer were randomly divided into two groups: additional injection of intramuscular progesterone the day of progesterone initiation or intramuscular progesterone the day of embryo transfer. We compare these results to our previous protocol beginning intramuscular progesterone day 22 of the treatment. Participants/materials, setting, methods Our frozen embryo transfer protocol consists to initiate GnRH agonist the day 1 of the cycle. After 14 days of estrogens, we introduce vaginal progesterone, prior to embryo transfer. Patients in group A received an additional injection of intramuscular progesterone the day of progesterone initiation. The group B received intramuscular progesterone the day of embryo transfer. For both, intramuscular injection of progesterone was followed every 3 days. Main results and the role of chance 239 patients were enrolled in this study, 125 in the group A and 114 in the group B. The ongoing pregnancy rate in the group A was 26.4 % and miscarriage rate 7.2%, not statistically different from ongoing pregnancy rate and miscarriage rate of women in the group B (22.81 %, p = 0.66/ 6.14%, p = 0.8). The ongoing pregnancy rate in the group D22 was 24.89 % et miscarriage rate 7.2%, not statistically different from ongoing pregnancy rate of women in the group A and B (p = 0.78 and p = 0.31). Limitations, reasons for caution The main limitation of our study is the lack of randomization for the group with additional progesterone IM on day 22. The study is actually followed to enroll more patients in 3 different groups. Wider implications of the findings This study tries to determine optimal adaptive management of hormonal replacement treatment for embryo transfer in patients with potential low progesterone values. Trial registration number no applicable

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