scholarly journals Trypanosoma cruzi lineage-specific serology: new rapid tests for resolving clinical and ecological associations

2019 ◽  
Vol 5 (10) ◽  
pp. FSO422 ◽  
Author(s):  
Tapan Bhattacharyya ◽  
Niamh Murphy ◽  
Michael A Miles
Keyword(s):  
Trypanosoma Cruzi ◽  
Rapid Tests ◽  
Ecological Associations

scholarly journals Geographic Variation in the Sensitivity of Recombinant Antigen-based Rapid Tests for Chronic Trypanosoma cruzi Infection

2009 ◽  
Vol 80 (3) ◽  
pp. 410-415 ◽  
Author(s):  
Jennifer R. Verani ◽  
Robert H. Gilman ◽  
Louis V. Kirchhoff ◽  
Lilia Cabrera ◽  
Viviana Pinedo-Cancino ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Geographic Variation ◽  
Recombinant Antigen ◽  
Rapid Tests ◽  
Cruzi Infection

Geographic variations in test reactivity for the serological diagnosis of Trypanosoma cruzi infection

2021 ◽  
Author(s):  
Carine Truyens ◽  
Eric Dumonteil ◽  
Jackeline Alger ◽  
Maria Luisa Cafferata ◽  
Alvaro Ciganda ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Test Performance ◽  
Elisa Test ◽  
Standard Test ◽  
Human Populations ◽  
Geographic Variations ◽  
Serological Tests ◽  
Rapid Tests ◽  
Antibody Levels ◽  
Cruzi Infection

Chagas disease is a neglected disease caused by Trypanosoma cruzi parasites. Most of diagnosis is based on serological tests but the lack of a gold standard test complicates the measurement of test performance. To overcome this limitation, we used samples from a cohort of well-characterized T. cruzi infected women to evaluate the reactivity of two rapid diagnostic tests and one ELISA assay. Our cohort derived from a previous study on congenital transmission of T. cruzi , and consisted in 481 blood/plasma samples from Argentina (n=149), Honduras (n=228) and Mexico (n=104) with at least one positive T. cruzi PCR. Reactivity of the three tests ranged from 70.5% for the Wiener ELISA to 81.0% for the T-Detect and 90.4% for the Stat-Pak rapid tests. Test reactivity varied significantly among countries, and was highest in Argentina, and lowest in Mexico. When considering at least two reactive serological tests to confirm seropositivity, over 12% of T. cruzi infection cases from Argentina were missed by serological tests, over 21% in Honduras, and an alarming 72% in Mexico. Differences in test performance among countries were not due to differences in parasitemia, but differences in antibody levels against ELISA test antigens were observed. Geographic differences in T. cruzi parasite strains as well as genetic differences among human populations may both contribute to the discrepancies in serological testing. Improvements in serological diagnostics for T. cruzi infections are critically needed to ensure an optimum identification of cases.

scholarly journals Molecular and serological rapid tests as markers of Trypanosoma cruzi infection in dogs in Costa Rica

2014 ◽  
Vol 4 (2) ◽  
pp. 111 ◽  
Author(s):  
Albert Picado ◽  
Andrea Urbina ◽  
Regina Lizundia ◽  
VictorM Montenegro ◽  
Stijn Deborggraeve ◽  
...  
Keyword(s):  
Costa Rica ◽  
Trypanosoma Cruzi ◽  
Rapid Tests ◽  
Cruzi Infection

Protective effect of Trypanosoma rangeli against infections with a highly virulent strain of Trypanosoma cruzi

1997 ◽  
Vol 2 (5) ◽  
pp. 482-487 ◽  
Author(s):  
Claudio Zuniga ◽  
Teresa Palau ◽  
Pilar Penin ◽  
Carlos Gamallo ◽  
Jose Antonio de Diego
Keyword(s):  
Trypanosoma Cruzi ◽  
Protective Effect ◽  
Virulent Strain ◽  
Trypanosoma Rangeli ◽  
Highly Virulent

Unusual dimeric flavonoids from Arrabidaea brachypoda with very significant in vitro and in vivo anti-Trypanosoma cruzi activity

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
C Quitino-da-Rocha ◽  
E Ferreira-Queiroz ◽  
C Santana-Meira ◽  
DR Magalhães-Moreira ◽  
M Botelho-Pereira-Soares ◽  
...  
Keyword(s):  
Trypanosoma Cruzi
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