scholarly journals Reproducibility, scientific rigor and responsibility

BioTechniques ◽  
2021 ◽  
Author(s):  
Ebony Torrington
Keyword(s):  
Biomedical Research ◽  
Scientific Rigor ◽  
Scientific Advancement ◽  
Data Credibility

Data credibility is very important for scientific advancement; however, experiments in biomedical research are not always reproducible.

scholarly journals Taming autoimmunity: Translating antigen-specific approaches to induce immune tolerance

2019 ◽  
Vol 216 (2) ◽  
pp. 247-250 ◽  
Author(s):  
José M. Carballido ◽  
Pere Santamaria
Keyword(s):  
Immune Tolerance ◽  
Biomedical Research ◽  
Executive Director ◽  
Preclinical Stage ◽  
Scientific Rigor ◽  
University Of Calgary ◽  
The University

José M. Carballido, Executive Director at Novartis Institutes for BioMedical Research, and Pere Santamaria, Professor of Immunology at the University of Calgary and Founder of Parvus Therapeutics Inc., discuss the opportunities and challenges of translating antigen-specific approaches for autoimmunity with an emphasis on the need for scientific rigor in the preclinical stage.

scholarly journals Rigorous Science: a How-To Guide

mBio ◽  
2016 ◽  
Vol 7 (6) ◽  
Author(s):  
Arturo Casadevall ◽  
Ferric C. Fang
Keyword(s):  
Statistical Analysis ◽  
Experimental Design ◽  
Biomedical Research ◽  
Scientific Rigor ◽  
Research Education ◽  
Intellectual Honesty ◽  
Logical Fallacies ◽  
Error Avoidance

ABSTRACT Proposals to improve the reproducibility of biomedical research have emphasized scientific rigor. Although the word “rigor” is widely used, there has been little specific discussion as to what it means and how it can be achieved. We suggest that scientific rigor combines elements of mathematics, logic, philosophy, and ethics. We propose a framework for rigor that includes redundant experimental design, sound statistical analysis, recognition of error, avoidance of logical fallacies, and intellectual honesty. These elements lead to five actionable recommendations for research education.

Applications of Scanning Microscopy in Biomedical Research

1968 ◽  
Vol 26 ◽  
pp. 354-355
Author(s):  
T. L. Hayes
Keyword(s):  
Information Content ◽  
Biomedical Research ◽  
Biomedical Applications ◽  
Three Dimensional ◽  
Dental Enamel ◽  
Resolving Power ◽  
Whole Mount ◽  
Two Parameters ◽  
Content Information ◽  
Sectioned Tissue

Biomedical applications of the scanning electron microscope (SEM) have increased in number quite rapidly over the last several years. Studies have been made of cells, whole mount tissue, sectioned tissue, particles, human chromosomes, microorganisms, dental enamel and skeletal material. Many of the advantages of using this instrument for such investigations come from its ability to produce images that are high in information content. Information about the chemical make-up of the specimen, its electrical properties and its three dimensional architecture all may be represented in such images. Since the biological system is distinctive in its chemistry and often spatially scaled to the resolving power of the SEM, these images are particularly useful in biomedical research.In any form of microscopy there are two parameters that together determine the usefulness of the image. One parameter is the size of the volume being studied or resolving power of the instrument and the other is the amount of information about this volume that is displayed in the image. Both parameters are important in describing the performance of a microscope. The light microscope image, for example, is rich in information content (chemical, spatial, living specimen, etc.) but is very limited in resolving power.

Ultrastructure and analytical microprobe analysis of simian lung mite pigments

1986 ◽  
Vol 44 ◽  
pp. 324-325
Author(s):  
R. W. Cole ◽  
J. C. Kim
Keyword(s):  
Biomedical Research ◽  
Tissue Damage ◽  
Microprobe Analysis ◽  
Old World Monkeys ◽  
Old World ◽  
Experimental Animals ◽  
The Past ◽  
Lung Mite ◽  
Mite Infestations ◽  
Cardiopulmonary System

In recent years, non-human primates have become indispensable as experimental animals in many fields of biomedical research. Pharmaceutical and related industries alone use about 2000,000 primates a year. Respiratory mite infestations in lungs of old world monkeys are of particular concern because the resulting tissue damage can directly effect experimental results, especially in those studies involving the cardiopulmonary system. There has been increasing documentation of primate parasitology in the past twenty years.

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