Changes of homocysteine levels and arterial endothelial function in patients with high risk of coronary artery disease after 6-month folic acid supplementation

2004 ◽  
Vol 59 (5) ◽  
pp. 503-506 ◽  
Author(s):  
Hangyuan GUO ◽  
Jong-Dae LEE ◽  
Yangbo XING ◽  
Jianfeng CHENG ◽  
Takanori UEDA ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Folic Acid ◽  
Coronary Artery ◽  
High Risk ◽  
Endothelial Function ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Artery Disease

Low-dose folic acid supplementation reduces homocysteine concentration in hyperhomocysteinemic coronary artery disease patients

2006 ◽  
Vol 26 (9) ◽  
pp. 460-466 ◽  
Author(s):  
Ping-Ting Lin ◽  
Bor-Jen Lee ◽  
Han-Hsin Chang ◽  
Chien-Hsiang Cheng ◽  
An-Jung Tsai ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Folic Acid ◽  
Coronary Artery ◽  
Low Dose ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Homocysteine Concentration ◽  
Artery Disease

scholarly journals Folic Acid Improves Endothelial Function in Coronary Artery Disease via Mechanisms Largely Independent of Homocysteine Lowering

Circulation ◽  
2002 ◽  
Vol 105 (1) ◽  
pp. 22-26 ◽  
Author(s):  
Sagar N. Doshi ◽  
Ian F.W. McDowell ◽  
Stuart J. Moat ◽  
Nicola Payne ◽  
Hilary J. Durrant ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Folic Acid ◽  
Coronary Artery ◽  
Endothelial Function ◽  
Artery Disease

High- but not low-dose folic acid improves endothelial function in coronary artery disease

2006 ◽  
Vol 36 (12) ◽  
pp. 850-859 ◽  
Author(s):  
S. J. Moat ◽  
A. Madhavan ◽  
S. Y. Taylor ◽  
N. Payne ◽  
R. H. Allen ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Folic Acid ◽  
Coronary Artery ◽  
Endothelial Function ◽  
Low Dose ◽  
Artery Disease

scholarly journals Folic acid does not improve endothelial function in healthy hyperhomocysteinaemic subjects

2004 ◽  
Vol 106 (4) ◽  
pp. 353-358 ◽  
Author(s):  
Richard J. WOODMAN ◽  
David E. CELERMAJER ◽  
Peter L. THOMPSON ◽  
Joseph HUNG
Keyword(s):  
Risk Factors ◽  
Folic Acid ◽  
Endothelial Function ◽  
Healthy Subjects ◽  
Folic Acid Supplementation ◽  
Double Blind ◽  
Acid Supplementation ◽  
Flow Mediated Dilatation ◽  
Artery Disease ◽  
Cad Risk

Folic acid supplementation lowers total plasma homocysteine (tHcy) and improves endothelial function in individuals with coronary artery disease (CAD) and in those with additional CAD risk factors. In the present study, we assessed whether endothelial function is impaired in healthy subjects with hyperhomocysteinaemia but without other CAD risk factors and whether folic acid supplementation improves endothelial function in these subjects. Flow-mediated dilatation (FMD) of the brachial artery was performed on 26 healthy subjects, age 49±2 years (mean±S.E.M.), with high tHcy (15.6±1.5 µmol/l) and 16 healthy age-matched subjects with low tHcy (7.9±0.6 µmol/l; P<0.001). Subjects with high tHcy were then randomized to receive 5 mg/day of folic acid or placebo for 8 weeks in a double-blind cross-over trial with a 4-week washout. FMD was not associated with tHcy and was not different between high and low tHcy groups (7.0±0.6% compared with 6.6±1.2%, P=0.76). Treatment with folic acid decreased tHcy by 34% in hyperhomocysteinaemic subjects (P=0.02 compared with placebo), but had no effect on FMD (+0.5±0.6% compared with -0.7±0.5%; P=0.17 compared with placebo). In healthy subjects with hyperhomocysteinaemia, but without additional cardiovascular risk, endothelial function is unimpaired and folic acid supplementation has no additional effect.

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