scholarly journals Membrane Protein Insertion Mechanism by Mitochondrial Sorting and Assembly Machinery Complex

2021 ◽  
Vol 61 (6) ◽  
pp. 392-394
Author(s):  
Hironori TAKEDA ◽  
Toshiya ENDO
Keyword(s):  
Membrane Protein ◽  
Protein Insertion ◽  
Membrane Protein Insertion ◽  
Insertion Mechanism

Structure of YidC from Thermotoga maritima and its implications for YidC‐mediated membrane protein insertion

2018 ◽  
Vol 32 (5) ◽  
pp. 2411-2421 ◽  
Author(s):  
Yanlong Xin ◽  
Yan Zhao ◽  
Jiangge Zheng ◽  
Haizhen Zhou ◽  
Xuejun Cai Zhang ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Thermotoga Maritima ◽  
Protein Insertion ◽  
Membrane Protein Insertion

Membrane protein import in yeast mitochondria

2000 ◽  
Vol 28 (4) ◽  
pp. 495-499 ◽  
Author(s):  
K. Tokatlidis ◽  
S. Vial ◽  
P. Luciano ◽  
M. Vergnolle ◽  
S. Clémence
Keyword(s):  
Membrane Protein ◽  
Molecular Mechanism ◽  
Protein Import ◽  
Mitochondrial Matrix ◽  
Yeast Mitochondria ◽  
Inner Membrane ◽  
Protein Insertion ◽  
The Past ◽  
Membrane Protein Insertion ◽  
Membrane Bound

The protein import pathway that targets proteins to the mitochondrial matrix has been extensively characterized in the past 15 years. Variations of this import pathway account for the sorting of proteins to other compartments as well, but the insertion of integral inner membrane proteins lacking a presequence is mediated by distinct translocation machinery. This consists of a complex of Tim9 and Tim10, two homologous, Zn2+-binding proteins that chaperone the passage of the hydrophobic precursor across the aqueous inter-membrane space. The precursor is then targeted to another, inner-membrane-bound, complex of at least five subunits that facilitates insertion. Biochemical and genetic experiments have identified the key components of this process; we are now starting to understand the molecular mechanism. This review highlights recent advances in this new membrane protein insertion pathway.

scholarly journals Membrane Protein Insertion into and Compatibility with Biomimetic Membranes

2017 ◽  
Vol 1 (7) ◽  
pp. 1700053 ◽  
Author(s):  
Tingwei Ren ◽  
Mustafa Erbakan ◽  
Yuexiao Shen ◽  
Eduardo Barbieri ◽  
Patrick Saboe ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Protein Insertion ◽  
Biomimetic Membranes ◽  
Membrane Protein Insertion
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