scholarly journals 1P402 Heterogeneity of cell population in continuous culture of Escherichia coli(16. Cell-cell communication,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

2006 ◽  
Vol 46 (supplement2) ◽  
pp. S247
Author(s):  
Makoto Sadamitsu ◽  
Chikara Furusawa ◽  
Akiko Kashiwagi ◽  
Tetsuya Yomo ◽  
Hiroshi Shimizu
Keyword(s):  
Escherichia Coli ◽  
Continuous Culture ◽  
Cell Population ◽  
Poster Session ◽  
Cell Communication ◽  
Meeting Program ◽  
Cell Cell

scholarly journals 1P408 Structure of Exopolysaccharide from the Biofilms of Thermus aquaticus YT-1(16. Cell-cell communication,Poster Session,Abstract,Meeting Program of EABS &BSJ 2006)

2006 ◽  
Vol 46 (supplement2) ◽  
pp. S248
Author(s):  
Miao_Hsia Lin ◽  
Yu_Liang Yang ◽  
Mao_Yuan Chen ◽  
Guang_Huey Lin ◽  
San_San Tsay ◽  
...  
Keyword(s):  
Poster Session ◽  
Cell Communication ◽  
Thermus Aquaticus ◽  
Meeting Program ◽  
Cell Cell

scholarly journals Quorum sensing and the population-dependent control of virulence

2000 ◽  
Vol 355 (1397) ◽  
pp. 667-680 ◽  
Author(s):  
Paul Williams ◽  
Miguel Camara ◽  
Andrea Hardman ◽  
Simon Swift ◽  
Deborah Milton ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Population Density ◽  
Cell Population ◽  
Cell Communication ◽  
Immunomodulatory Activity ◽  
Signal Molecules ◽  
Dependent Manner ◽  
Virulence Determinants ◽  
Signal Molecule ◽  
Cell Cell

One crucial feature of almost all bacterial infections is the need for the invading pathogen to reach a critical cell population density sufficient to overcome host defences and establish the infection. Controlling the expression of virulence determinants in concert with cell population density may therefore confer a significant survival advantage on the pathogen such that the host is overwhelmed before a defence response can be fully initiated. Many different bacterial pathogens are now known to regulate diverse physiological processes including virulence in a cell–density–dependent manner through cell–cell communication. This phenomenon, which relies on the interaction of a diffusible signal molecule (e.g. an N –acylhomoserine lactone) with a sensor or transcriptional activator to couple gene expression with cell population density, has become known as ‘quorum sensing’ . Although the size of the ‘quorum’ is likely to be highly variable and influenced by the diffusibility of the signal molecule within infected tissues, nevertheless quorum–sensing signal molecules can be detected in vivo in both experimental animal model and human infections. Furthermore, certain quorum–sensing molecules have been shown to possess pharmacological and immunomodulatory activity such that they may function as virulence determinants per se . As a consequence, quorum sensing constitutes a novel therapeutic target for the design of small molecular antagonists capable of attenuating virulence through the blockade of bacterial cell–cell communication.

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