scholarly journals 1P247 Association of neuronal mRNA transport complex and mitochondria

2005 ◽  
Vol 45 (supplement) ◽  
pp. S93
Author(s):  
K. Shinkura ◽  
N. Shiina ◽  
K. Sakata-Sogawa ◽  
M. Tokunaga
Keyword(s):  
Mrna Transport ◽  
Transport Complex

Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex

2017 ◽  
Vol 24 (2) ◽  
pp. 152-161 ◽  
Author(s):  
Franziska Theresia Edelmann ◽  
Andreas Schlundt ◽  
Roland Gerhard Heym ◽  
Andreas Jenner ◽  
Annika Niedner-Boblenz ◽  
...  
Keyword(s):  
Molecular Architecture ◽  
Mrna Transport ◽  
Ash1 Mrna ◽  
Transport Complex

scholarly journals Neuronal mRNA transport complex : its ultrastructure and protein constituents

2003 ◽  
Vol 43 (supplement) ◽  
pp. S234
Author(s):  
K. Sninkura ◽  
N. Shiina ◽  
M. Tokunaga
Keyword(s):  
Mrna Transport ◽  
Transport Complex

scholarly journals 3P224 Association of neuronal mRNA transport complex and mitochondrial rRNA

2004 ◽  
Vol 44 (supplement) ◽  
pp. S245
Author(s):  
K. Shinkura ◽  
N. shiina ◽  
K. Sakata-Sogawa ◽  
M. Tokunaga
Keyword(s):  
Mrna Transport ◽  
Mitochondrial Rrna ◽  
Transport Complex

scholarly journals Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Thomas E Sladewski ◽  
Neil Billington ◽  
M Yusuf Ali ◽  
Carol S Bookwalter ◽  
Hailong Lu ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Protein Complex ◽  
Binding Protein ◽  
Full Length ◽  
Mrna Transport ◽  
Binding Partners ◽  
Mrna Binding Protein ◽  
Transport Complex ◽  
Mrna Binding

We investigated the role of full-length Drosophila Bicaudal D (BicD) binding partners in dynein-dynactin activation for mRNA transport on microtubules. Full-length BicD robustly activated dynein-dynactin motility only when both the mRNA binding protein Egalitarian (Egl) and K10 mRNA cargo were present, and electron microscopy showed that both Egl and mRNA were needed to disrupt a looped, auto-inhibited BicD conformation. BicD can recruit two dimeric dyneins, resulting in faster speeds and longer runs than with one dynein. Moving complexes predominantly contained two Egl molecules and one K10 mRNA. This mRNA-bound configuration makes Egl bivalent, likely enhancing its avidity for BicD and thus its ability to disrupt BicD auto-inhibition. Consistent with this idea, artificially dimerized Egl activates dynein-dynactin-BicD in the absence of mRNA. The ability of mRNA cargo to orchestrate the activation of the mRNP (messenger ribonucleotide protein) complex is an elegant way to ensure that only cargo-bound motors are motile.

RIBONUCLEOPROTEIN PARTICLES CONTAINING mRNA and pre-mRNA

1973 ◽  
Vol 74 (Suppl) ◽  
pp. S130-S167 ◽  
Author(s):  
O. P. Samarina ◽  
E. M. Lukanidin ◽  
G. P. Georgiev
Keyword(s):  
Structural Organization ◽  
General Scheme ◽  
Biological Significance ◽  
Mrna Transport ◽  
Ribonucleoprotein Particles ◽  
Mrna Precursor

ABSTRACT This paper is a review of the data concerning the nature, structural organization, properties and biological significance of the particles, containing mRNA and pre-mRNA (precursor of mRNA), i. e., (1) nuclear pre-mRNA-containing particles (2) free cytoplasmic mRNP (ribonucleoproteins), or informosomes (3) polysome-bound mRNP. Some new data on the comparison of nuclear and cytoplasmic particles, the nature of poly A-containing structures, involvement of informofers in Adenovirusspecific RNA transfer are presented. The general scheme of mRNA transport from nucleus to cytoplasm is discussed.

scholarly journals The role of CPEB family proteins in the nervous system function in the norm and pathology

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eugene Kozlov ◽  
Yulii V. Shidlovskii ◽  
Rudolf Gilmutdinov ◽  
Paul Schedl ◽  
Mariya Zhukova
Keyword(s):  
Nervous System ◽  
Gene Regulation ◽  
Neural Development ◽  
Fragile X ◽  
Autism Spectrum ◽  
Mrna Transport ◽  
Ribonucleoprotein Complexes ◽  
Posttranscriptional Gene Regulation ◽  
Nervous System Function ◽  
Functional Features

AbstractPosttranscriptional gene regulation includes mRNA transport, localization, translation, and regulation of mRNA stability. CPEB (cytoplasmic polyadenylation element binding) family proteins bind to specific sites within the 3′-untranslated region and mediate poly- and deadenylation of transcripts, activating or repressing protein synthesis. As part of ribonucleoprotein complexes, the CPEB proteins participate in mRNA transport and localization to different sub-cellular compartments. The CPEB proteins are evolutionarily conserved and have similar functions in vertebrates and invertebrates. In the nervous system, the CPEB proteins are involved in cell division, neural development, learning, and memory. Here we consider the functional features of these proteins in the nervous system of phylogenetically distant organisms: Drosophila, a well-studied model, and mammals. Disruption of the CPEB proteins functioning is associated with various pathologies, such as autism spectrum disorder and brain cancer. At the same time, CPEB gene regulation can provide for a recovery of the brain function in patients with fragile X syndrome and Huntington's disease, making the CPEB genes promising targets for gene therapy.

Characterization of Sodium-Dependent [3H]GBR-12935 Binding in Brain: A Radioligand for Selective Labelling of the Dopamine Transport Complex

1986 ◽  
Vol 46 (4) ◽  
pp. 1272-1276 ◽  
Author(s):  
Aaron Janowsky ◽  
Paul Berger ◽  
Frank Vocci ◽  
Rodrigo Labarca ◽  
Phil Skolnick ◽  
...  
Keyword(s):  
Selective Labelling ◽  
Sodium Dependent ◽  
Dopamine Transport ◽  
Transport Complex
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