scholarly journals Common binding mechanism and classification of Group II and III WW domains

2003 ◽  
Vol 43 (supplement) ◽  
pp. S93
Author(s):  
Y. Kato ◽  
K. Nagata ◽  
Marius Sudol ◽  
M. Tanokura
Keyword(s):  
Binding Mechanism ◽  
Ww Domains ◽  
Group Ii

ISOLATION AND CLASSIFICATION OF EXTRANUCLEAR MUTANTS OF NEUROSPORA CRASSA

Genetics ◽  
1972 ◽  
Vol 71 (4) ◽  
pp. 521-533
Author(s):  
H Bertrand ◽  
T H Pittenger
Keyword(s):  
Cytochrome C ◽  
Neurospora Crassa ◽  
Slow Growth ◽  
Nuclear Factor ◽  
Group Iii ◽  
Group I ◽  
Growth Phenotype ◽  
Group Ii

ABSTRACT Four extranuclear mutants, [exn-1], [exn-2],[exn-4], and [stp-C], were obtained from N-methyl-N'-nitro-N-nitrosoguanidine-treated conidia and mycelium of Neurospora crassa. The three exn mutants grow with a pronounced lag from conidia and ascospores and are female fertile, whereas [stp-C] has a stop-start growth phenotype and is female sterile. The mitochondria from all four mutants are deficient in cytochromes a+a  3 and b, but contain an excess of cytochrome c. On the basis of growth and fertility, nuclear suppressors and complementation in heteroplasmons, 16 of the extranuclear mutants now available in Neurospora can be divided into three groups. Group I consists of 8 female-fertile variants with both poky-like growth and cytochrome defects. Their slow growth is suppressed by the nuclear factor, f, but not by a second nuclear suppressor, su-1([mi-3]). They complement with group III mutants in mixed cytoplasmons. Group II is represented by a single variant, [mi-3]. It is phenotypically modified by the su-1([mi-3]) factor, but not by f. Its unique cytochrome spectrum shows a deficiency of cytochrome a, but c and b are present. It complements in heteroplasmons with group I and III mutants. Group III included 7 female-sterile variants with stopper growth phenotypes and the same cytochrome defects as group I. Group III mutants complement both with group I and II isolates, but they are unaffected by either f or su-1.

scholarly journals Cultural adaptation and the Clavien-Dindo surgical complications classification translated to Brazilian Portuguese.

2016 ◽  
Vol 43 (3) ◽  
pp. 141-148 ◽  
Author(s):  
LUIS FERNANDO MOREIRA ◽  
MARCELO CASTRO MARÇAL PESSÔA ◽  
DIEGO SACHET MATTANA ◽  
FERNANDO FERNANDES SCHMITZ ◽  
BERNARDO SILVEIRA VOLKWEIS ◽  
...  
Keyword(s):  
Surgical Complications ◽  
Brazilian Portuguese ◽  
P Value ◽  
Porto Alegre ◽  
Group I ◽  
Overall Performance ◽  
Group Ii ◽  
Level Of Experience ◽  
Different Levels

ABSTRACT Objective: to generate a translated and validated version of the Clavien-Dindo Classification of Surgical Complications (CDC) to Brazilian Portuguese (CDC-BR). Methods: the process of translation and adaptation followed the guideline of Beaton et al., 2000. We divided 76 participating surgeons, in different levels of experience, from the Department Surgery of the Hospital de Clínicas de Porto Alegre, into two groups: Group I applied the original version (CDC, n=36);r Group II used the modified version (CDC-BR, n=40). Each group classified 15 clinical cases of surgical complications. We compared performance between the groups (Mann-Whitney test) relating to the level of experience of the surgeon (Kruskal-Wallis test), considering p value <0.05 as significant. Results: the performance of the Group II (CDC-BR) was higher, with 85% accuracy, compared with 79% of Group I (CDC), p-value =0.012. The performance of the groups as for surgeons experience displayed p=0.171 for Group I, p=0.528 for Group II, and p=0.135 for overall performance. Conclusion: we produced a translated and validated version of the CDC for Brazilian Portuguese. The instrument will be a useful tool in the production of evidence on surgical outcomes.

scholarly journals On the maximal connected algebraic subgroups of the Cremona group I

1982 ◽  
Vol 88 ◽  
pp. 213-246 ◽  
Author(s):  
Hiroshi Umemura
Keyword(s):  
Cremona Group ◽  
Group I ◽  
Group Ii ◽  
General Method

This paper is a continuation of the two preceding papers [12], [13] where the classification of the de Jonquières type subgroups in the Cremona group of 3 variables is promised. However the classification of such subgroups is postponed until the article in preparation “On the maximal connected algebraic subgroups of the Cremona group II”. The purpose of this paper is to establish a general method to study algebraic subgroups in the Cremona group of n variables and to illustrate how it works and leads to the classification of Enriques (Theorem (2.25)) when applied to the 2 variable case. This method gives us also the classification of the maximal connected algebraic subgroups of the Cremona group of 3 variables.

HYPOGONADISM, GALACTORRHOEA AND HYPER-PROLACTINAEMIA: EVALUATION OF PITUITARY GONADOTROPHINS RESERVE BEFORE AND UNDER BROMOCRIPTINE

1977 ◽  
Vol 84 (4) ◽  
pp. 738-749 ◽  
Author(s):  
M. Asfour ◽  
M. L'Hermite ◽  
M. Hedouin-Quincampoix ◽  
P. Fossati
Keyword(s):  
Sella Turcica ◽  
Complete Evaluation ◽  
Group Iii ◽  
Group I ◽  
Radiological Abnormality ◽  
Group Ii ◽  
Pituitary Prolactin ◽  
Hypothalamic Level ◽  
Rule Out

ABSTRACT Twenty patients with hypogonadism (19 women with amenorrhoea and 1 man with impotence and infertility), galactorrhoea and hyper-prolactinaemia (range: 36 to 344 ng/ml) were studied. The radiological study of the sella turcica, including in all cases hypocycloidal tomograms, allowed classification of the patients into 3 groups: group I (n = 4) had a grossly enlarged sella turcica, group II (n = 12) had localized alterations indicating the probable existence of a prolactin-secreting microadenoma ("microdeformation") while group III patients presented no radiological abnormality. Before treatment, all the patients were submitted to a complete evaluation of the function of their anterior pituitary, including the LH and FSH responses to iv administration of Gn-RH. All the group I patients had low basal LH levels and a blunted response to Gn-RH. The basal LH and in response to Gn-RH were normal in most of the group II patients and in all of the group III patients. An exaggerated FSH response to Gn-RH was observed in 6/12 patients with microdeformation (group II) but not in groups I and III patients. A low LH and a blunted LH response to Gn-RH is highly suggestive of the existence of a pituitary prolactin-secreting adenoma in case of amenorrhoea and hyper-prolactinaemia patients; a normal response does not however rule out such a diagnosis. The reasons for an exaggerated FSH response to Gn-RH in patients with suspected prolactin-secreting microadenoma remain to be investigated though this pattern can also occur in other cases of amenorrhoea. Hence the Gn-RH test might contribute to the assessment of the hypothalamo-pituitary axis of patients with hyper-prolactinaemia. Six patients treated for 4 months with bromocriptine (CB-154) were submitted to re-evaluation of their pituitary gonadotrophins reserve. All the women experienced restoration of menses with 39 days of treatment and the male patient regained potency. It was observed that bromocriptine treatment and subsequent normalized prolactin levels in the 4 group II women tested were associated with normalization of their previously exaggerated FSH response to Gn-RH; LH responses were also diminished in these cases. These data are compatible with the hypothesis that hyper-prolactinaemia per se could interfere with the endogenous secretion of Gn-RH at the hypothalamic level. In one patient with grossly enlarged sella turcica and a previous lack of an LH and FSH response to Gn-RH, bromocriptine treatment restored a normal gonadotrophins response, confirming that, in this case, the alteration of this response was indeed due to a prolonged lack of endogenous Gn-RH secretion.

scholarly journals Sequencing of Porcine Enterovirus Groups II and III Reveals Unique Features of Both Virus Groups

2002 ◽  
Vol 76 (11) ◽  
pp. 5813-5821 ◽  
Author(s):  
Andi Krumbholz ◽  
Malte Dauber ◽  
Andreas Henke ◽  
Eckhard Birch-Hirschfeld ◽  
Nick J. Knowles ◽  
...  
Keyword(s):  
Molecular Classification ◽  
Stem Loop ◽  
Group Iii ◽  
Porcine Enterovirus ◽  
Group Ii ◽  
Cloverleaf Structure

ABSTRACT The molecular classification of the porcine enterovirus (PEV) groups II and III was investigated. The sequence of the almost complete PEV-8 (group II) genome reveals that this virus has unique L and 2A gene regions. A reclassification of this group into a new picornavirus genus is suggested. PEV group III viruses are typical enteroviruses. They differ from other enteroviruses by a prolonged stem-loop D of the 5′-cloverleaf structure.

Distribution of Progeny by Cryptus inornatus Pratt (Hymenoptera: Ichneumonidae)

1949 ◽  
Vol 81 (12) ◽  
pp. 285-299 ◽  
Author(s):  
G. C. Ullyett
Keyword(s):  
Ephestia Kuehniella ◽  
Present Writer ◽  
Host Insect ◽  
Group Ii ◽  
The Relationship

In a previous paper (Ullyett, 1949). the present writer outlined a tentative classification of insects serving as hosts to entomophagous parasites. This scheme was based upon the more obvious relationships that exist between parasite and host insect and those which might conceivably have some hearing upon the degree of efficiency with which the females of the former distribute their progeny among available hosts. Five main groups were recognized which reflected the differences occurring between the various kinds of hosts and parasites encountered in the field. Of these, examples have already been dealt with from two of the groups, viz., Group II, in which the host is normally active but is paralysed by the parasite before oviposition, as exemplified by the distribution of eggs by the Braconid, Microbracon hebetor Say among the larvae of Ephestia kuehniella Zell. (Ullyett. 1945); Group IIIA, in which the host is stationary and fully exposed as illustrated by the relationship between the eggs of Ephestia and the attack of Chelonus texanus Cress. (Ullyett, 1949).

scholarly journals Identification and Classification of Reverse Transcriptases in Bacterial Genomes and Metagenomes

2021 ◽  
Author(s):  
Fatemeh Sharifi ◽  
Yuzhen Ye
Keyword(s):  
Template Switching ◽  
Group Ii Introns ◽  
Bacterial Genomes ◽  
Computational Tools ◽  
Reverse Transcriptases ◽  
Group Ii ◽  
Cell Suicide ◽  
Reference Genomes ◽  
Genomic Neighborhood

ABSTRACTReverse Transcriptases (RTs) are found in different systems including group II introns, Diversity Generating Retroelements (DGRs), retrons, CRISPR-Cas systems, and Abortive Infection (Abi) systems in prokaryotes. Different classes of RTs can play different roles, such as template switching and mobility in group II introns, spacer acquisition in CRISPR-Cas systems, mutagenic retrohoming in DGRs, programmed cell suicide in Abi systems, and recently discovered phage defense in retrons. While some classes of RTs have been studied extensively, others remain to be characterized. There is a lack of computational tools for identifying and characterizing various classes of RTs. In this study, we built a tool (called myRT) for identification and classification of prokaryotic RTs. In addition, our tool provides information about the genomic neighborhood of each RT, providing potential functional clues. We applied our tool to predict and classify RTs in all complete and draft bacterial genomes, and created a collection that can be used for exploration of putative RTs. Application of myRT to gut metagenomes showed that gut metagenomes encode proportionally more RTs related to DGRs, outnumbering retron-related RTs, as compared to the collection of reference genomes. MyRT is both available as a standalone software and also through a website.

Infrared Analysis of Isomerized, Vulcanized, and Oxidized Natural Rubber

1955 ◽  
Vol 28 (1) ◽  
pp. 213-223 ◽  
Author(s):  
G. Salomon ◽  
A. Chr van der Schee
Keyword(s):  
Double Bond ◽  
Infrared Spectrum ◽  
Natural Rubber ◽  
Infrared Spectra ◽  
Infrared Analysis ◽  
Side Group ◽  
Oxidation Reactions ◽  
Absorption Bands ◽  
Group Ii

Abstract This paper is a continuation of our study on the infrared spectra of natural rubber and its derivatives. It was found previously that, in certain reactions of rubber, the original double bond (I) is shifted to the side group (II) and that this leads to significant changes in the chemical and mechanical behavior of the polymer. Others have also reported the occurrence of groups (II) and (III) in rubber and certain rubber derivatives. Group (II) is also found in synthetic polyisoprenes as a result of 3,4-polymerization. We have now measured the intensities of the absorption bands of the rubber spectrum and changes produced by cyclization and isomerization. Certain statements on the formation of (II) and (III) during vulcanization were at variance with our experience, but a detailed investigation cleared up some misconceptions. Modifications brought about by oxidation are chemically related to those produced by sulfuration reactions. A classification of oxidation reactions, based on typical changes in the infrared spectrum, will be proposed in the discussion.

Clinico-Etiological Classification of Epilepsy in Children Presenting To Specialty Epilepsy Clinic at Tertiary Medical Centre

2017 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Selection Criteria ◽  
Clinical Presentation ◽  
Refractory Epilepsy ◽  
Perinatal Asphyxia ◽  
Group Iii ◽  
Dimensional Classification ◽  
Group I ◽  
Etiological Spectrum ◽  
Group Ii

Objectives: To identify the clinical & etiological profile of children and the characteristics of seizures in them along with therapeutic responses. Methods: All patients who attended the Epilepsy Clinic & fulfilled the selection criteria were enrolled in study. This is a descriptive study of 12 months & involved analysis of records of the patients who came to specialty OPD. Three groups were formed accordingly - focal, generalized & unknown onset with further etiological sub-divisions -Genetic, Structural/Metabolic, Immune, Infectious & Unknown. Results: In all, 417 patients were studied. The distribution as per clinical presentation was- group I (generalized) 215(58.5%) - group II (focal) 154(36.9%), group III (unknown) 48(4.6%). The main etiologies were perinatal asphyxia (28.3%) NHBI (11.4%) in (structural-metabolic) sub group. In Genetic & Infectious, Channelopathies (10.5%) & Post Meningitis Sequelae (4.7%). 56.3% of the patient in group II were on more than 3 AEDs. 14.3% in group I were weaned of AEDs. 61.4% patients in group II were having neuro-developmental sequelae. EEG revealed abnormal activity in 30(6.2%) in group I & 31(19.3%) in group II. Maximum patient with refractory epilepsy were seen in group III. Conclusion: To have a good management of epilepsy we need to have multi-dimensional classification of epilepsy based on both clinical & etiological spectrum. Perinatal Asphyxia & NHBI are one of the most common yet avertible etiologies.

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