scholarly journals Unique quadruplex structure of GGA triplet repeat DNA and its biological significance

2003 ◽  
Vol 43 (supplement) ◽  
pp. S27
Author(s):  
A. Matsugami ◽  
K. Ouhashi ◽  
T. Okuizumi ◽  
T. Ikeda ◽  
H. Sotoya ◽  
...  
Keyword(s):  
Biological Significance ◽  
Triplet Repeat ◽  
Quadruplex Structure ◽  
Repeat Dna

Fast separation of oligonucleotide and triplet repeat DNA on a microfabricated capillary electrophoresis device and capillary electrophoresis

2000 ◽  
Vol 21 (1) ◽  
pp. 176-180 ◽  
Author(s):  
Masanori Ueda ◽  
Yuriko Kiba ◽  
Hirohisa Abe ◽  
Akihiro Arai ◽  
Hiroaki Nakanishi ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Triplet Repeat ◽  
Fast Separation ◽  
Repeat Dna

scholarly journals Intramolecular Higher Order Packing of Parallel Quadruplexes Comprising a G:G:G:G Tetrad and a G(:A):G(:A):G(:A):G Heptad of GGA Triplet Repeat DNA

2003 ◽  
Vol 278 (30) ◽  
pp. 28147-28153 ◽  
Author(s):  
Akimasa Matsugami ◽  
Tomoyuki Okuizumi ◽  
Seiichi Uesugi ◽  
Masato Katahira
Keyword(s):  
Higher Order ◽  
Triplet Repeat ◽  
Repeat Dna

An intramolecular quadruplex of (GGA)4 triplet repeat DNA with a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad, and its dimeric interaction

2001 ◽  
Vol 313 (2) ◽  
pp. 255-269 ◽  
Author(s):  
Akimasa Matsugami ◽  
Kiyoshi Ouhashi ◽  
Mayumi Kanagawa ◽  
Hui Liu ◽  
Sakura Kanagawa ◽  
...  
Keyword(s):  
Triplet Repeat ◽  
Repeat Dna

scholarly journals Duplex formation in a G-quadruplex bulge

2020 ◽  
Vol 48 (18) ◽  
pp. 10567-10575 ◽  
Author(s):  
Thi Quynh Ngoc Nguyen ◽  
Kah Wai Lim ◽  
Anh Tuân Phan
Keyword(s):  
Base Pair ◽  
Solution Structure ◽  
Biological Significance ◽  
Consensus Definition ◽  
Quadruplex Structure ◽  
G Quadruplex ◽  
Structural Details ◽  
The Stability ◽  
Definition Of ◽  
Duplex Formation

Abstract Beyond the consensus definition of G-quadruplex-forming motifs with tracts of continuous guanines, G-quadruplexes harboring bulges in the G-tetrad core are prevalent in the human genome. Here, we study the incorporation of a duplex hairpin within a bulge of a G-quadruplex. The NMR solution structure of a G-quadruplex containing a duplex bulge was resolved, revealing the structural details of the junction between the duplex bulge and the G-quadruplex. Unexpectedly, instead of an orthogonal connection the duplex stem was observed to stack below the G-quadruplex forming a unique quadruplex–duplex junction. Breaking up of the immediate base pair step at the junction, coupled with a narrowing of the duplex groove within the context of the bulge, led to a progressive transition between the quadruplex and duplex segments. This study revealed that a duplex bulge can be formed at various positions of a G-quadruplex scaffold. In contrast to a non-structured bulge, the stability of a G-quadruplex slightly increases with an increase in the duplex bulge size. A G-quadruplex structure containing a duplex bulge of up to 33 nt in size was shown to form, which was much larger than the previously reported 7-nt bulge. With G-quadruplexes containing duplex bulges representing new structural motifs with potential biological significance, our findings would broaden the definition of potential G-quadruplex-forming sequences.

scholarly journals Fast Separation of Oligonucleotide and Triplet Repeat DNA on a Microfabricated Capillary Electrophoresis Device.

2000 ◽  
Vol 16 (6) ◽  
pp. 657-658 ◽  
Author(s):  
Masanori UEDA ◽  
Yuriko KIBA ◽  
Hirohisa ABE ◽  
Hiroki KUYAMA ◽  
Akihiro ARAI ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Triplet Repeat ◽  
Fast Separation ◽  
Repeat Dna
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