scholarly journals Formation of graded cell arrangement by cell repulsion

2001 ◽  
Vol 41 (supplement) ◽  
pp. S83
Author(s):  
H. Honda ◽  
A. Mochizuki
Keyword(s):  
Cell Arrangement ◽  
Cell Repulsion

scholarly journals Regulation of EphB2 activation and cell repulsion by feedback control of the MAPK pathway

2008 ◽  
Vol 183 (5) ◽  
pp. 933-947 ◽  
Author(s):  
Alexei Poliakov ◽  
Maria L. Cotrina ◽  
Andrea Pasini ◽  
David G. Wilkinson
Keyword(s):  
Feedback Loop ◽  
Fibroblast Growth Factor Receptor ◽  
Mapk Pathway ◽  
Tyrosine Phosphatase ◽  
Growth Factor Receptor ◽  
Mitogen Activated Protein Kinase ◽  
Eph Receptor ◽  
Mitogen Activated Protein ◽  
Mediate Cell ◽  
Cell Repulsion

In this study, we investigated whether the ability of Eph receptor signaling to mediate cell repulsion is antagonized by fibroblast growth factor receptor (FGFR) activation that can promote cell invasion. We find that activation of FGFR1 in EphB2-expressing cells prevents segregation, repulsion, and collapse responses to ephrinB1 ligand. FGFR1 activation leads to increased phosphorylation of unstimulated EphB2, which we show is caused by down-regulation of the leukocyte common antigen–related tyrosine phosphatase receptor that dephosphorylates EphB2. In addition, FGFR1 signaling inhibits further phosphorylation of EphB2 upon stimulation with ephrinB1, and we show that this involves a requirement for the mitogen-activated protein kinase (MAPK) pathway. In the absence of activated FGFR1, EphB2 activates the MAPK pathway, which in turn promotes EphB2 activation in a positive feedback loop. However, after FGFR1 activation, the induction of Sprouty genes inhibits the MAPK pathway downstream of EphB2 and decreases cell repulsion and segregation. These findings reveal a novel feedback loop that promotes EphB2 activation and cell repulsion that is blocked by transcriptional targets of FGFR1.

scholarly journals Channeled polysaccharide-based hydrogel reveals influence of curvature to guide endothelial cell arrangement in vessel-like structures

2021 ◽  
Vol 118 ◽  
pp. 111369
Author(s):  
Teresa Simon-Yarza ◽  
Marie-Noëlle Labour ◽  
Rachida Aid ◽  
Didier Letourneur
Keyword(s):  
Endothelial Cell ◽  
Cell Arrangement
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