scholarly journals Strong Selection of a Few Dominant CD8 Clones in a TLR7-Dependent Autoimmune Mouse Model

immuneACCESS ◽  
2019 ◽  
Author(s):  
P Morawski ◽  
S Bolland
Keyword(s):  
Mouse Model ◽  
Strong Selection ◽  
Autoimmune Mouse ◽  
Selection Of

scholarly journals Emergence of Fluoroquinolone Resistance in Mycobacterium tuberculosis during Continuously Dosed Moxifloxacin Monotherapy in a Mouse Model

2005 ◽  
Vol 49 (9) ◽  
pp. 3977-3979 ◽  
Author(s):  
Amy Sarah Ginsburg ◽  
Ronggai Sun ◽  
Heather Calamita ◽  
Cherise P. Scott ◽  
William R. Bishai ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mouse Model ◽  
Fluoroquinolone Resistance ◽  
Drug Concentrations ◽  
Resistant Mutants ◽  
Selection Of

ABSTRACT Fluoroquinolone resistance in tuberculosis may rapidly emerge. Mice infected with high titers of aerosolized Mycobacterium tuberculosis and treated for 8 weeks with four concentrations of moxifloxacin (0.125, 0.25, 0.50, and 1.0%) mixed into the diet had drug concentrations of 2.4, 4.1, 5.3, and 17.9 μg/ml, respectively, in blood. Selection of fluoroquinolone-resistant mutants occurred in all surviving mice.

scholarly journals Soap Films as 1D waveguides

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Olivier Emile ◽  
Janine Emile
Keyword(s):  
Film Thickness ◽  
Laser Light ◽  
Soap Film ◽  
Mode Propagation ◽  
Free Standing ◽  
One Dimensional ◽  
Strong Selection ◽  
Self Selection ◽  
Optical Modes ◽  
Selection Of

AbstractLaser light is injected in a free standing horizontal draining soap film through the glass frame sustaining the film. Two propagation regimes are clearly identified depending on the film thickness. At the beginning of the drainage, the soap film behaves as a multimode-one dimensional optofiuidic waveguide. In particular, we observe that the injected light creates a bottleneck in the film and part of the injected light is refracted leading to whiskers. At the end of the drainage where the film thickness is below 1μm, there is a strong selection among the various possible optical modes in the film, and part of the light is defiected. This leads to a self selection of the mode propagation inside the film.

Plasmodium berghei K173: Selection of resistance to naphthoquine in a mouse model

2011 ◽  
Vol 127 (2) ◽  
pp. 436-439 ◽  
Author(s):  
Hong Wang ◽  
Zhu-Chun Bei ◽  
Jing-Yan Wang ◽  
Wu-Chun Cao
Keyword(s):  
Mouse Model ◽  
Plasmodium Berghei ◽  
Selection Of ◽  
Selection Of Resistance

scholarly journals Assessment of carbapenems in a mouse model of Mycobacterium tuberculosis infection

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0249841
Author(s):  
Ravindra Jadhav ◽  
Ricardo Gallardo-Macias ◽  
Gaurav Kumar ◽  
Samer S. Daher ◽  
Amit Kaushik ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mouse Model ◽  
Small Molecules ◽  
Lessons Learned ◽  
Learning Approach ◽  
Mycobacterium Tuberculosis Infection ◽  
Pharmacokinetic Profiles ◽  
Machine Learning Approach ◽  
Selection Of

We present further study of a subset of carbapenems, arising from a previously reported machine learning approach, with regard to their mouse pharmacokinetic profiling and subsequent study in a mouse model of sub-acute Mycobacterium tuberculosis infection. Pharmacokinetic metrics for such small molecules were compared to those for meropenem and biapenem, resulting in the selection of two carbapenems to be assessed for their ability to reduce M. tuberculosis bacterial loads in the lungs of infected mice. The original syntheses of these two carbapenems were optimized to provide multigram quantities of each compound. One of the two experimental carbapenems, JSF-2204, exhibited efficacy equivalent to that of meropenem, while both were inferior to rifampin. The lessons learned in this study point toward the need to further enhance the pharmacokinetic profiles of experimental carbapenems to positively impact in vivo efficacy performance.

Tissue-specific selection of reference genes is required for expression studies in the mouse model of maternal protein undernutrition

2011 ◽  
Vol 76 (3) ◽  
pp. 558-569 ◽  
Author(s):  
E.S. Lucas ◽  
A.J. Watkins ◽  
A.L. Cox ◽  
S.J. Marfy-Smith ◽  
N. Smyth ◽  
...  
Keyword(s):  
Mouse Model ◽  
Reference Genes ◽  
Tissue Specific ◽  
Expression Studies ◽  
Selection Of

scholarly journals Translational Relevance of Mouse Models of Atopic Dermatitis

2021 ◽  
Vol 10 (4) ◽  
pp. 613
Author(s):  
Justin Choi ◽  
Nishadh Sutaria ◽  
Youkyung Sophie Roh ◽  
Zachary Bordeaux ◽  
Martin P. Alphonse ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mouse Model ◽  
Mouse Models ◽  
Murine Model ◽  
Current Understanding ◽  
Th2 Inflammation ◽  
Selection Of

The complexity of atopic dermatitis (AD) continues to present a challenge in the appropriate selection of a mouse model because no single murine model completely recapitulates all aspects of human AD. This has been further complicated by recent evidence of the distinct AD endotypes that are dictated by unique patterns of inflammation involving Th1, Th2, Th17, and Th22 axes. A review of currently used mouse models demonstrates that while all AD mouse models consistently exhibit Th2 inflammation, only some demonstrate concomitant Th17 and/or Th22 induction. As the current understanding of the pathogenic contributions of these unique endotypes and their potential therapeutic roles expands, ongoing efforts to maximize a given mouse model’s homology with human AD necessitates a close evaluation of its distinct immunological signature.

scholarly journals The Red Dwarf Stars of the UV Ceti-Type in the Neighbourhood of the Sun

1971 ◽  
Vol 15 ◽  
pp. 138-143
Author(s):  
N. I. Shakhovskaya ◽  
E. Schöffel
Keyword(s):  
South Africa ◽  
The Sun ◽  
Dwarf Stars ◽  
Strong Selection ◽  
Appreciable Increase ◽  
The Crimea ◽  
Type Variable ◽  
Ceti Type ◽  
Red Dwarf Stars ◽  
Selection Of

The intensive patrol observations of red dwarf stars during last years, carried out in the Crimea, Chile, Catania, South Africa, Armenia, Japan and other observatories led to appreciable increase of number of known UV Ceti-type objects. It permits us to complete the known lists of the variables (1—4). At the same time it is worth-while to define more precisely the criteria to consider a star as the UV Ceti-type variable, and to carry out strong selection of the certain UV Cet-type variables from the objects suspected to be this type variables.

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