Buffer Location and Sizing to Optimize Cost and Quality in Semi-Continuous Manufacturing Processes: Methodology and Application

2008 ◽  
Author(s):  
Kumar Rajaram ◽  
Zhili Tian
Keyword(s):  
Manufacturing Processes ◽  
Continuous Manufacturing

Control of Continuous Manufacturing Processes for Production of Monoclonal Antibodies

2021 ◽  
pp. 39-74
Author(s):  
Anurag S. Rathore ◽  
Garima Thakur ◽  
Saxena Nikita ◽  
Shantanu Banerjee
Keyword(s):  
Monoclonal Antibodies ◽  
Manufacturing Processes ◽  
Continuous Manufacturing

An Enhanced Quality Evaluation System for Continuous Manufacturing Processes, Part 1: Theory

1990 ◽  
Vol 112 (1) ◽  
pp. 57-62 ◽  
Author(s):  
K. J. Dooley ◽  
S. G. Kapoor
Keyword(s):  
Evaluation System ◽  
Quality Evaluation ◽  
Quality Characteristic ◽  
Rule Base ◽  
Manufacturing Processes ◽  
Cusum Chart ◽  
Continuous Manufacturing ◽  
Chi Square ◽  
Chi Square Test ◽  
Quality Evaluation System

A quality evaluation system is presented which gives enhanced information about the nature of quality changes in continuous manufacturing processes. The system monitors a quality characteristic of the process via stochastic time series models and detects shifts in the process mean, variance, and dynamic parameters. A rule base classifies the type of change that occurred, and change magnitude and time of occurrence are estimated. Part 1 of the work addresses the theoretical issues concerning the statistics used by the rule base and their behavior under various process changes. The characteristics of the cusum chart, autocorrelation chart, and Chi-Square test are derived with respect to each of the possible change mechanisms.

Progress in the Development of Continuous Manufacturing Processes for HTS Conductors

1993 ◽  
pp. 811-814
Author(s):  
H.-W. Neumüller ◽  
W. Schmidt ◽  
M. Wilhelm ◽  
U. Härlen ◽  
G. Hofer ◽  
...  
Keyword(s):  
Manufacturing Processes ◽  
Continuous Manufacturing

scholarly journals Towards Continuous Primary Manufacturing Processes—Particle Design through Combined Crystallization and Particle Isolation

Processes ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 2187
Author(s):  
Claas Steenweg ◽  
Anne Cathrine Kufner ◽  
Jonas Habicht ◽  
Kerstin Wohlgemuth
Keyword(s):  
Quality Control ◽  
Product Quality ◽  
Scale Up ◽  
Small Scale ◽  
Manufacturing Processes ◽  
Continuous Manufacturing ◽  
Product Quality Control ◽  
Combined Crystallization ◽  
Fast Start ◽  
Continuous Vacuum

Integrated continuous manufacturing processes of active pharmaceutical ingredients (API) provide key benefits concerning product quality control, scale-up capability, and a reduced time-to-market. Thereby, the crystallization step, which is used in approximately 90% of API productions, mainly defines the final API properties. This study focuses on the design and operation of an integrated small-scale process combining a continuous slug flow crystallizer (SFC) with continuous particle isolation using the modular continuous vacuum screw filter (CVSF). By selective adjustment of supersaturation and undersaturation, the otherwise usual blocking could be successfully avoided in both apparatuses. It was shown that, during crystallization in an SFC, a significant crystal growth of particles (Δd50,3≈ 220 µm) is achieved, and that, during product isolation in the CVSF, the overall particle size distribution (PSD) is maintained. The residual moistures for the integrated process ranged around 2% during all experiments performed, ensuring free-flowing particles at the CVSF outlet. In summary, the integrated setup offers unique features, such as its enhanced product quality control and fast start-up behavior, providing a promising concept for integrated continuous primary manufacturing processes of APIs.

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