Identification of ZER6 Isoform p52-ZER6 as an Antitumour Therapeutic Response Determinant for MDM2-p53 Binding Inhibitors

2022 ◽  
Author(s):  
Wenfang Li ◽  
Leader Alfason ◽  
Can Huang ◽  
Yu Tang ◽  
Li Qiu ◽  
...  
Keyword(s):  
Therapeutic Response ◽  
Binding Inhibitors

Ixekizumab in the Management of Non-Selected Out Patients with Moderate to Severe Psoriasis -New Data and Personal Clinical Experience

2018 ◽  
Vol 3 (3) ◽  
Keyword(s):  
Clinical Experience ◽  
Personal Experience ◽  
Therapeutic Response ◽  
Systemic Disease ◽  
Severe Psoriasis ◽  
Adequate Treatment ◽  
Scalp Psoriasis ◽  
Number Of Patients ◽  
Genital Psoriasis

Introduction: Too many patients with moderate to severe psoriasis do not receive adequate treatment. This means a vast undersupply in the treatment of patients with psoriasis. Only biologics fulfill the whole range of the treatment of psoriasis – psoriasis does not affect only skin but the whole organism: It is a systemic disease! Between the biologics are evident differences concerning the effect. Discussion: Based on broad personal experience in the management of patients with moderate to severe psoriasis new data from clinical studies with ixekizumab are examined. This contains new data on long-term-efficacy of ixekizumab, effectiveness in special localizations (scalp psoriasis, nail psoriasis, palmoplantar psoriasis, genital psoriasis) as well as safely data and experience on patients switched to ixekizumab from other biologics. Personal clinical experience is based on >300 non-selected outpatients with moderate to severe psoriasis, >250 patients on biological therapies, > 50 patients with ixekizumab. Conclusions: Focusing on a relevant number of patients switched from secukinumab to ixekizumab due to first or secondary loss of efficacy significant differences between both IL-17A-inhibitors mainly in terms of efficacy and speed of therapeutic response are shown. Finally the correlation between PASI-90-/PASI-100 response and significant changes in DLQI are highlighted.

Therapeutic response to recombinat somatropin in children with isolated deficiency of GH

2013 ◽  
Author(s):  
Sandra Belo ◽  
Claudia Nogueira ◽  
Susana Corujeira ◽  
Carla Costa ◽  
Cintia Castro-Correia ◽  
...  
Keyword(s):  
Therapeutic Response

Clinical predictors of therapeutic response to SGLT-2 inhibitors

2018 ◽  
Author(s):  
Carolina Garcia-Figueras-Mateos ◽  
Manuel Cayon-Blanco
Keyword(s):  
Therapeutic Response ◽  
Clinical Predictors

Imaging cardiac sarcoidosis and infiltrative diseases: diagnosis and therapeutic response

2020 ◽  
Vol 64 (1) ◽  
Author(s):  
Mohamed Y. Elwazir ◽  
John P. Bois ◽  
Omar F. Abouezzeddine ◽  
Panithaya Chareonthaitawee
Keyword(s):  
Therapeutic Response ◽  
Cardiac Sarcoidosis
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