Persistent Ebola Virus Infection within the Male Reproductive Tract is Related to Both Viral Replication Kinetics and Host Response at the Blood-Testis Barrier

2022 ◽  
Author(s):  
Andrew L. Webb ◽  
Brayden G. Schindell ◽  
Bryan D. Griffin ◽  
Geoff Soule ◽  
Abu B. Siddik ◽  
...  
Keyword(s):  
Virus Infection ◽  
Viral Replication ◽  
Host Response ◽  
Ebola Virus ◽  
Reproductive Tract ◽  
Male Reproductive Tract ◽  
Ebola Virus Infection ◽  
Blood Testis Barrier

scholarly journals Passive Transfer of Antibodies Protects Immunocompetent and Immunodeficient Mice against Lethal Ebola Virus Infection without Complete Inhibition of Viral Replication

2001 ◽  
Vol 75 (10) ◽  
pp. 4649-4654 ◽  
Author(s):  
Manisha Gupta ◽  
Siddhartha Mahanty ◽  
Mike Bray ◽  
Rafi Ahmed ◽  
Pierre E. Rollin
Keyword(s):  
Virus Infection ◽  
Viral Replication ◽  
Ebola Virus ◽  
Protective Efficacy ◽  
Hemorrhagic Fever ◽  
Passive Transfer ◽  
Immune Serum ◽  
Immunodeficient Mice ◽  
Ebola Hemorrhagic Fever ◽  
Ebola Virus Infection

ABSTRACT Ebola hemorrhagic fever is a severe, usually fatal illness caused by Ebola virus, a member of the filovirus family. The use of nonhomologous immune serum in animal studies and blood from survivors in two anecdotal reports of Ebola hemorrhagic fever in humans has shown promise, but the efficacy of these treatments has not been demonstrated definitively. We have evaluated the protective efficacy of polyclonal immune serum in a mouse model of Ebola virus infection. Our results demonstrate that mice infected subcutaneously with live Ebola virus survive infection and generate high levels of anti-Ebola virus immunoglobulin G (IgG). Passive transfer of immune serum from these mice before challenge protected upto 100% of naive mice against lethal Ebola virus infection. Protection correlated with the level of anti-Ebola virus IgG titers, and passive treatment with high-titer antiserum was associated with a delay in the peak of viral replication. Transfer of immune serum to SCID mice resulted in 100% survival after lethal challenge with Ebola virus, indicating that antibodies alone can protect from lethal disease. Thus antibodies suppress or delay viral growth, provide protection against lethal Ebola virus infection, and may not require participation of other immune components for protection.

scholarly journals Antibody-Dependent Enhancement of Ebola Virus Infection

2003 ◽  
Vol 77 (13) ◽  
pp. 7539-7544 ◽  
Author(s):  
Ayato Takada ◽  
Heinz Feldmann ◽  
Thomas G. Ksiazek ◽  
Yoshihiro Kawaoka
Keyword(s):  
Virus Infection ◽  
Ebola Virus ◽  
Human Populations ◽  
Hemorrhagic Disease ◽  
Viral Infectivity ◽  
Kidney Cells ◽  
Emerging Pathogens ◽  
Viral Glycoprotein ◽  
Antibody Dependent Enhancement ◽  
Ebola Virus Infection

ABSTRACT Most strains of Ebola virus cause a rapidly fatal hemorrhagic disease in humans, yet there are still no biologic explanations that adequately account for the extreme virulence of these emerging pathogens. Here we show that Ebola Zaire virus infection in humans induces antibodies that enhance viral infectivity. Plasma or serum from convalescing patients enhanced the infection of primate kidney cells by the Zaire virus, and this enhancement was mediated by antibodies to the viral glycoprotein and by complement component C1q. Our results suggest a novel mechanism of antibody-dependent enhancement of Ebola virus infection, one that would account for the dire outcome of Ebola outbreaks in human populations.

scholarly journals Loss of Interleukin 1 Receptor Antagonist Enhances Susceptibility to Ebola Virus Infection

2015 ◽  
Vol 212 (suppl 2) ◽  
pp. S329-S335 ◽  
Author(s):  
Lindsay Hill-Batorski ◽  
Peter Halfmann ◽  
Andrea Marzi ◽  
Tiago J. S. Lopes ◽  
Gabriele Neumann ◽  
...  
Keyword(s):  
Virus Infection ◽  
Receptor Antagonist ◽  
Ebola Virus ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist ◽  
Ebola Virus Infection

scholarly journals Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig

2020 ◽  
Vol 181 ◽  
pp. 104863 ◽  
Author(s):  
Thomas R. Lane ◽  
Christopher Massey ◽  
Jason E. Comer ◽  
Alexander N. Freiberg ◽  
Huanying Zhou ◽  
...  
Keyword(s):  
Virus Infection ◽  
Guinea Pig ◽  
Ebola Virus ◽  
Ebola Virus Infection
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