Socio-Economic Consequences of Cushing's Syndrome: A Nationwide Cohort Study

2022 ◽  
Author(s):  
Andreas Ebbehoj ◽  
Esben Søndergaard ◽  
Peter Jepsen ◽  
Kirstine Stochholm ◽  
Helene Mathilde Lundsgaard Svane ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Economic Consequences

scholarly journals Incidence of Venous Thromboembolism in Patients with Cushing's Syndrome: A Multicenter Cohort Study

2011 ◽  
Vol 96 (11) ◽  
pp. 3525-3532 ◽  
Author(s):  
D. J. F. Stuijver ◽  
B. van Zaane ◽  
R. A. Feelders ◽  
J. Debeij ◽  
S. C. Cannegieter ◽  
...  
Keyword(s):  
Cohort Study ◽  
Venous Thromboembolism ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Multicenter Cohort Study ◽  
Multicenter Cohort

scholarly journals Health-related quality of life of patients with hypothalamic–pituitary–adrenal axis dysregulations: a cohort study

2017 ◽  
Vol 177 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Charlotte De Bucy ◽  
Laurence Guignat ◽  
Tanya Niati ◽  
Jérôme Bertherat ◽  
Joel Coste
Keyword(s):  
Quality Of Life ◽  
Cohort Study ◽  
Hpa Axis ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Hpa Axis Dysregulation

ObjectiveHealth-related quality of life (HrQoL) is increasingly considered to be an important outcome of care for hypothalamic–pituitary–adrenal (HPA) axis dysregulation. The objective of this study was to assess the influence of type of HPA axis dysregulation and cortisol status on HrQOL and its evolution with time and treatment.DesignProspective cohort study.MethodsBetween September 2007 and April 2014, HrQoL questionnaires were administered during routine management to all patients with HPA axis dysregulation hospitalized in a single department, and this was repeated after 6- 12-, 24- and 36-month during standard follow-up. The Medical Outcomes Study 36‐item short‐form health survey (SF‐36) and the General Health Questionnaire 12 (GHQ-12) were used simultaneously, with a common time schedule to measure the impact of HPA axis dysregulation on HrQoL. Multivariate mixed linear regression models were constructed to adjust for potential confounders.Results343 patients (206 with Cushing’s syndrome of pituitary origin, 91 with Cushing’s syndrome of adrenal origin and 46 with Addison’s disease) responded to the questionnaires. Overall, HrQoL scores were well below population values. Cushing syndrome of pituitary origin was associated with worse HrQoL, especially in physical dimensions. More than half of the patients, of all diagnoses and cortisol status, had psychological distress requiring attention according to the GHQ-12. Hypercortisolism had the greatest negative influence on HrQoL.ConclusionsHRQoL appears significantly altered by all forms of HPA axis dysregulation, and most substantially and broadly by Cushing’s syndrome, notably during periods of hypercortisolism. These effects on HRQoL deserve further consideration both in clinical practice and research.

scholarly journals Multisystem Morbidity and Mortality in Cushing's Syndrome: A Cohort Study

2013 ◽  
Vol 98 (6) ◽  
pp. 2277-2284 ◽  
Author(s):  
Olaf M. Dekkers ◽  
Erzsébet Horváth-Puhó ◽  
Jens Otto L. Jørgensen ◽  
Suzanne C. Cannegieter ◽  
Vera Ehrenstein ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Morbidity And Mortality

scholarly journals Cushing’s syndrome in children and adolescents: a Danish nationwide population-based cohort study

2017 ◽  
Vol 176 (5) ◽  
pp. 567-574 ◽  
Author(s):  
Johanne Marie Holst ◽  
Erzsébet Horváth-Puhó ◽  
Rikke Beck Jensen ◽  
Mariane Rix ◽  
Kurt Kristensen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Children And Adolescents ◽  
Cushing’S Syndrome ◽  
Pediatric Population ◽  
Age Groups ◽  
Young Patients ◽  
Cushing's Syndrome ◽  
Registration System ◽  
Increased Risk ◽  
Icd Codes

Objective Cushing’s syndrome (CS) affects all age groups, but epidemiologic data in young patients are very limited. We therefore examined the incidence, prevalence and hospital morbidity of CS in children and adolescents. Design In a nationwide cohort study, we included all Danish citizens aged 0–20 years from 1977 to 2012. Data were obtained from the Danish National Patient Registry using the International Classification of Diseases (ICD) codes and the Danish Civil Registration System. The diagnosis and treatment were validated by means of individual patient charts. Incidence rate of CS patients aged 0–20 years at diagnosis were computed (standardized to the age and sex distribution of the Danish population). The patients were followed for a maximum of 36 years. Standardized incidence ratios (SIRs) of different hospital-recorded outcomes based on the ICD codes in patients with CS compared to the general population were assessed. Results We identified a total of 40 pediatric patients with CS, yielding an annual incidence of 0.89 cases/106 population (95% confidence interval (CI) = 0.63–1.16). The median age at the time of diagnosis was 13.8 years (interquartile range: 10.5–18.2 years), 58% were female and 70% had adrenocorticotropic hormone-producing pituitary adenomas. During follow-up, CS patients (excluding three malignant cases) were at increased risk of being diagnosed with infections (SIR: 3.24, 95% CI: 1.05–7.54) and infertility (SIR: 4.56, 95% CI: 1.48–10.63). The three patients with an adrenocortical carcinoma died shortly after diagnosis, but mortality was not increased in the remaining patients. Conclusions CS is rare in the pediatric population. The risk of morbidity related to infections and infertility is elevated and merits further attention.

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