Bladder Cancer-Derived Exosomal KRT6B Promotes Invasion and Metastasis by Inducing EMT and Regulating the Immune Microenvironment

2022 ◽  
Author(s):  
Qiang Song ◽  
Hao Yu ◽  
Yidong Cheng ◽  
Jie Han ◽  
Kai Li ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Invasion And Metastasis ◽  
Immune Microenvironment

Using oncolytic viruses to ignite the tumour immune microenvironment in bladder cancer

2021 ◽  
Author(s):  
Roger Li ◽  
Jingsong Zhang ◽  
Scott M. Gilbert ◽  
José Conejo-Garcia ◽  
James J. Mulé
Keyword(s):  
Bladder Cancer ◽  
Oncolytic Viruses ◽  
Immune Microenvironment

Tumor immune microenvironment drives prognostic relevance correlating with bladder cancer subtypes

2019 ◽  
Vol 18 (1) ◽  
pp. e1455-e1456 ◽  
Author(s):  
P. Strissel ◽  
C. Pfannstiel ◽  
K. Chiappinelli ◽  
D. Sikic ◽  
S. Wach ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Immune Microenvironment ◽  
Cancer Subtypes ◽  
Prognostic Relevance ◽  
Tumor Immune Microenvironment

scholarly journals Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer

Oncogene ◽  
2012 ◽  
Vol 32 (7) ◽  
pp. 894-902 ◽  
Author(s):  
R Saito ◽  
R Shirakawa ◽  
H Nishiyama ◽  
T Kobayashi ◽  
M Kawato ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Invasion ◽  
Gtpase Activating Protein ◽  
Invasion And Metastasis ◽  
Ral Gtpase

scholarly journals ID2 Inhibits Bladder Cancer Progression and Metastasis via PI3K/AKT Signaling Pathway

2021 ◽  
Vol 9 ◽  
Author(s):  
Weipu Mao ◽  
Keyi Wang ◽  
Si Sun ◽  
Jianping Wu ◽  
Ming Chen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Clinical Samples ◽  
Low Grade ◽  
Akt Signaling Pathway ◽  
Invasion And Metastasis ◽  
Id Proteins

Background: Inhibitors of DNA-binding (ID) proteins are important regulators of cell proliferation and differentiation. The aim of this study was to evaluated the role of ID proteins in bladder cancer (BCa) and related molecular mechanisms.Methods: The TCGA database was analyzed for the expression and clinical significance of ID proteins. The expression of ID2 was determined by qRT-PCR, immunohistochemical staining and western blot. The role of ID2 was determined by CCK-8, colony formation, wound healing, transwell and xenograft tumor assays, and the potential mechanism of ID2 in BCa was investigated by RNA sequencing.Results: ID2 expression was significantly downregulated in TCGA database and clinical samples, and high ID2 expression was associated with low-grade tumor staging and correlated with better overall survival, disease specific survival (DSS) and progress free interval (PFI). In vivo and in vitro experiments showed that knockdown of ID2 promoted proliferation, migration, invasion and metastasis of BCa cells, while overexpression of ID2 significantly inhibited cell proliferation, migration, invasion and metastasis. Mechanistically, ID2 acts as a tumor suppressor through PI3K/AKT signaling pathway to inhibit the progression and metastasis of BCa.Conclusion: Our results suggest that ID2 exerts tumor suppressive effects in BCa through PI3K/AKT signaling pathway, and altered ID2 expression can be used as a biomarker of BCa progression and metastasis.

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